A5088768504- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Nicotinic Acetylcholine Receptors Study
- Pain Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Circadian rhythm and melatonin
- Ion channel regulation and function
- Pancreatic function and diabetes
- Genetic Mapping and Diversity in Plants and Animals
- Cannabis and Cannabinoid Research
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Protein Kinase Regulation and GTPase Signaling
- Neuroscience of respiration and sleep
- Bacterial Identification and Susceptibility Testing
- Peroxisome Proliferator-Activated Receptors
- Syphilis Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Neurogenesis and neuroplasticity mechanisms
- Cardiac Ischemia and Reperfusion
- Animal Genetics and Reproduction
Horizon Therapeutics (United States)
2023
Northwestern University
2016-2019
Aptinyx (United States)
2016-2019
Virginia Commonwealth University
2010-2018
Institute of Alcohol Studies
2014
Society for Neuroscience
2014
Virginia Commonwealth University Medical Center
2014
Institute of Pharmacology
2014
University of California, San Francisco
2007-2010
Ernest Gallo Clinic and Research Center
2006-2010
Orexin A/hypocretin-1 (oxA/hcrt-1) is known to be a modulator of dopamine-dependent neuronal activity and behaviors. However, the role this system in driving motivated behaviors remains poorly understood. Here, we show that orexin/hypocretin receptor-1 (ox/hcrt-1R) signaling important for motivation highly salient, positive reinforcement. Blockade ox/hcrt-1R selectively reduced work self-administer cocaine or high fat food pellets. Moreover, oxA/hcrt-1 strengthened presynaptic glutamatergic...
Using sensory information for the prediction of future events is essential survival. Midbrain dopamine neurons are activated by environmental cues that predict rewards, but cellular mechanisms underlie this phenomenon remain elusive. We used in vivo voltammetry and vitro patch-clamp electrophysiology to show both release reward predictive enhanced synaptic strength onto develop over course cue-reward learning. Increased was not observed after stable behavioral responding. Thus, may act...
Background: Continued consumption of alcohol despite deleterious consequences is a hallmark alcoholism and represents critical challenge to therapeutic intervention. Previous rat studies showed that enduring self‐administration pairing with normally aversive stimuli was only observed after very long‐term intake (>8 months). Aversion‐resistant has been previously interpreted indicate pathological or compulsive motivation consume alcohol. However, given the time required model seeking in...
Changing the activity of ventral tegmental area (VTA) dopamine neurons from pacemaker to burst firing is hypothesized increase salience stimuli, such as an unexpected reward, and likely contributes withdrawal-associated drug-seeking behavior. Accordingly, pharmacological, behavioral, electrophysiological data suggest important role VTA in mediating alcohol-dependent behaviors. However, effects repeated ethanol exposure on neuron ion channel function are poorly understood. Here, we repeatedly...
Synaptodendritic injury is thought to underlie HIV-associated neurocognitive disorders and contributes exaggerated inflammation cognitive impairment seen in opioid abusers with HIV-1. To examine events triggering combined transactivator of transcription (Tat)- morphine-induced synaptodendritic systematically, striatal neuron imaging studies were conducted <i>in vitro</i>. These demonstrated nearly identical pathologic increases dendritic varicosities as Tat transgenic mice vivo</i>. caused...
A bstract : variety of data point to the possibility that neuroadaptations in glutamate transmission are produced by repeated exposure cocaine result expression behaviors characteristic addiction, such as craving and relapse. Using reinstatement model relapse rats, release projection from prefrontal cortex nucleus accumbens has been shown underlie cocaine‐ stress‐primed reinstatement. In this report, four adaptations withdrawal described may regulate underlying drug‐seeking resulted. (1)...
Approximately 90% of alcoholics relapse within 4 years, in part because an enhanced motivation to seek alcohol (EtOH). A novel G protein modulator (Gpsm1/AGS3) was up-regulated the rat nucleus accumbens core (NAcore) but not other limbic nuclei during abstinence from operant EtOH self-administration. Furthermore, NAcore AGS3 knockdown reduced seeking pre-abstinence levels a model compulsive, human seeking. can both inhibit Giα-mediated signaling and stimulate Gβγ-mediated signaling....
Astrocytes actively participate in synaptic plasticity and respond to insult or metabotropic glutamate receptor activation with increased expression of the intermediate filament glial fibrillary acidic protein (GFAP). Extended withdrawal from repeated cocaine administration induces many forms neuroplasticity. The present study rats utilized a 3-week period daily (i.p.; 7 days) investigate whether astrocytes cocaine-mediated observed brain nuclei associated addiction. Following period,...
Alcohol dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified.
Levels of the mRNA <i>NAC-1</i> are increased in rat forebrain weeks after cocaine exposure. This long-term neuroadaptation occurs during expression behavioral sensitization, a model psychostimulant-induced paranoia. NAC-1, protein encoded by this cocaine-regulated mRNA, contains Pox virus and zinc finger/bric-a-brac tramtrack broad complex (POZ/BTB) motif, which mediates interactions among several transcriptional regulators. The present studies demonstrate that NAC-1 acts as transcription...
Background Prefrontal cortex (PFC) dysfunction is believed to contribute the transition from controlled substance use abuse. Because astrocytes have been suggested play a key role in development and maintenance of drug-seeking behaviors, we sought determine whether PFC are affected by ethanol (EtOH) self-administration. Methods EtOH consumption was modeled rats 3 self-administration paradigms where made concurrently available with water home cage either continuously (CEA) or intermittently...