A5017786335- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Stress Responses and Cortisol
- Neuropeptides and Animal Physiology
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Regulation of Appetite and Obesity
- Neuroscience and Neural Engineering
- Analytical Methods in Pharmaceuticals
- Eicosanoids and Hypertension Pharmacology
- Biochemical Analysis and Sensing Techniques
- Hormonal Regulation and Hypertension
- Alcohol Consumption and Health Effects
- Nicotinic Acetylcholine Receptors Study
- PI3K/AKT/mTOR signaling in cancer
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Metabolism and Genetic Disorders
- Blind Source Separation Techniques
- Protein Kinase Regulation and GTPase Signaling
- Phosphodiesterase function and regulation
- Advanced Fluorescence Microscopy Techniques
University of Illinois Chicago
2024
University of Maryland, Baltimore
2016-2021
University of North Carolina at Chapel Hill
2003-2014
Center for Alcohol Studies
2014
Center for Neurosciences
2014
Indiana University School of Medicine
2014
University of California, San Francisco
2010-2013
Ernest Gallo Clinic and Research Center
2009-2013
Virginia Commonwealth University
2010
Rutgers, The State University of New Jersey
2003
Background: Continued consumption of alcohol despite deleterious consequences is a hallmark alcoholism and represents critical challenge to therapeutic intervention. Previous rat studies showed that enduring self‐administration pairing with normally aversive stimuli was only observed after very long‐term intake (>8 months). Aversion‐resistant has been previously interpreted indicate pathological or compulsive motivation consume alcohol. However, given the time required model seeking in...
Forming and breaking associations between emotionally salient environmental stimuli rewarding or aversive outcomes is an essential component of learned adaptive behavior. Importantly, when cue-reward contingencies degrade, animals must exhibit behavioral flexibility to extinguish prior associations. Understanding the specific neural circuit mechanisms that operate during formation extinction conditioned behaviors critical because dysregulation these processes hypothesized underlie many...
Background: Drinking in the dark (DID) procedures have recently been developed to induce high levels of ethanol drinking C57BL/6J mice, which result blood concentrations (BECs) reaching that measurable affects on physiology and/or behavior. The present experiments determined whether increased caused by DID can be attenuated pretreatment with CP‐154,526; a corticotropin releasing factor type‐1 (CRF 1 ) receptor antagonist. Methods: In Experiment 1, male mice received (20% v/v) place water for...
The development of excessive fear and/or stress responses to environmental cues such as contexts associated with a traumatic event is hallmark post-traumatic disorder (PTSD). basolateral amygdala (BLA) has been implicated key structure mediating contextual conditioning. In addition, the hippocampus an integral role in encoding and processing strong, salient stimuli fear. Given that both BLA play important regulation conditioning, examining functional connectivity between these two structures...
The neural circuitry underlying mammalian reward behaviors involves several distinct nuclei throughout the brain. It is widely accepted that midbrain dopamine (DA) neurons are critical for reward-related behaviors. Recent studies have shown centromedial nucleus of amygdala (CeMA) has a role in regulating However, CeMA and ventromedial PFC (vmPFC) interaction regulation remains poorly understood. Here, we identify dissect GABAergic projection originates terminates vmPFC (VGat-CreCeMA-vmPFC)...
Drinking in the dark (DID) procedures have recently been developed to induce high levels of ethanol drinking C57BL/6J mice, which result blood concentrations reaching that measurable affects on physiology and/or behavior. The present study determined if increased associated with DID may be motivated by caloric need rather than postingestive pharmacological effects ethanol. To this end, food availability was manipulated or mice were given peripheral administration orexigenic anorectic agents...
ABSTRACT Mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are implicated neuropsychiatric disorders including autism. Previous studies report that PTEN knockdown neurons vivo leads to increased spine density synaptic activity. To better characterize changes lacking PTEN, we examined the effects of shRNA basolateral amygdala morphology by using fluorescent dye confocal imaging. Contrary previous dentate gyrus, find a significant decrease total distal dendrites....
Background Corticotropin releasing factor ( CRF ) and urocortin play an important role in many stress responses also can regulate ethanol E t OH intake. Adaptations signaling the central amygdala promote consumption after long‐term intake dependent animals brief periods of binge Thus, even episodes alter function system, allowing to Here, we examined whether leads receptor adaptations within ventral tegmental area VTA ), a structure involved rewarding aversive events development expression...
Background: The alcohol deprivation effect (ADE) is characterized by transient excessive consumption upon reinstatement of ethanol following a period deprivation. While this phenomenon has been observed in rats using both bottle drinking (consummatory behavior) and operant self‐administration appetitive “ethanol‐seeking” procedures, ADE studies mice have primarily relied on measures. Furthermore, the neurochemical pathways that modulate are not well understood. Therefore, we determined...
Background: Genetic and pharmacological evidence suggests that the cyclic adenosine monophosphate–dependent protein kinase A pathway modulates neurobiological responses to ethanol. Mutant mice lacking RIIβ subunit of (RIIβ −/− ) are resistant ethanol‐induced sedation drink significantly more ethanol than littermate wild‐type +/+ ). We determined whether high intake by on alternate genetic backgrounds is reliably predicted basal levels anxiety or resistance sedative effects Methods:...
Abstract Individuals suffering from substance use disorder often experience relapse events that are attributed to drug craving. Insular cortex (IC) function is implicated in processing drug‐predictive cues and thought be a critical substrate for craving, but the downstream neural circuit effectors of IC mediate reward poorly described. Here, we uncover functional connectivity an projection ventral bed nucleus stria terminalis (vBNST), portion extended amygdala has been previously shown...
Neuropeptide Y (NPY) is a 36-amino acid neuromodulator that expressed throughout the central nervous system. Recent genetic and pharmacological evidence suggests NPY Y1 receptor modulates ethanol intake. To further characterize role of receptor, we examined voluntary consumption by mice after administration [(-)-2-[1-(3-chloro-5-isopropyloxycarbonylaminophenyl)ethylamino]-6-[2-(5-ethyl-4-methyl-1,3-tiazol-2-yl)ethyl]-4-morpholinopyridine] (compound A), novel selective antagonist (Y1RA) acts...