Philip A. Karlsson

ORCID: 0000-0003-0060-005X
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About
Contact & Profiles
Research Areas
  • Urinary Tract Infections Management
  • Yersinia bacterium, plague, ectoparasites research
  • Clostridium difficile and Clostridium perfringens research
  • Probiotics and Fermented Foods
  • Antibiotic Resistance in Bacteria
  • Microbial Metabolism and Applications
  • Pickering emulsions and particle stabilization
  • Bacterial Identification and Susceptibility Testing
  • Gut microbiota and health
  • Escherichia coli research studies
  • Brucella: diagnosis, epidemiology, treatment
  • Advanced Drug Delivery Systems
  • Bacillus and Francisella bacterial research
  • Antibiotics Pharmacokinetics and Efficacy
  • Microbial infections and disease research
  • Antibiotic Use and Resistance
  • Salmonella and Campylobacter epidemiology
  • Pediatric Urology and Nephrology Studies
  • Surfactants and Colloidal Systems
  • Liquid Crystal Research Advancements
  • Reproductive tract infections research
  • Pelvic floor disorders treatments
  • Berberine and alkaloids research

Uppsala University
2021-2025

The foodborne pathogen Yersinia enterocolitica causes gastrointestinal infections worldwide. In the spring of 2019, Swedish Public Health Agency and Statens Serum Institut in Denmark independently identified an outbreak caused by 4/O:3 that after sequence comparison turned out to be a cross-border outbreak. A trace-back investigation suggested shipments fresh prewashed spinach from Italy as common source for Here, we determined genome sequences five Y. clinical isolates during using...

10.3389/fmicb.2021.664665 article EN cc-by Frontiers in Microbiology 2021-05-13

Abstract Chlamydia trachomatis (CT) may employ persistence to evade antimicrobial clearance, possibly residing in the gastrointestinal tract. This study assessed reliability of droplet digital PCR (ddPCR) CT detection, its functionality viability assessment, and predictions on transmission dynamics by combining (vPCR) clinical data from 52 infected women. The ddPCR showed 94% positive 100% negative agreement with Abbott Alinity STI-M for endocervical samples, 92% 87% rectal samples....

10.1038/s41598-025-85297-4 article EN cc-by Scientific Reports 2025-01-10

β-Lactam antibiotics are the first choice for treatment of most bacterial infections. However, increased prevalence β-lactamases, in particular extended-spectrum pathogenic bacteria has severely limited possibility using β-lactam treatments.

10.1128/aac.00290-22 article EN Antimicrobial Agents and Chemotherapy 2022-06-02

Antibiotics are essential for treating infections and reducing risks during medical interventions.However, many commonly used antibiotics lack the physiochemical properties an efficient oral administration when systemic infection.Instead, we reliant on intravenous delivery, which presents complications outside of clinical settings.Developing novel formulations is a potential solution to this problem.We engineered hexosome cubosome liquid crystal nanoparticles (LCNPs) characterized by...

10.1016/j.jcis.2024.08.230 article EN cc-by Journal of Colloid and Interface Science 2024-08-31

ABSTRACT Urinary tract infections (UTIs), traditionally dominated by Gram-negative pathogens, are increasingly complicated antimicrobial-resistant Enterococcus spp. in hospital settings. This study screened urine samples from 210 ICU patients at Uppsala University Hospital (June 2020 - September 2021), identifying 39 unique PhenePlate™-RF types across E. faecium , faecalis and durans . isolates showed considerable genetic diversity, primarily within clonal complex 17 (CC17), known for its...

10.1101/2024.10.18.619042 preprint EN bioRxiv (Cold Spring Harbor Laboratory) 2024-10-18

Objectives High frequency of antimicrobial prescription and the nature prolonged illness in COVID-19 increases risk for complicated bacteriuria antibiotic resistance. We investigated factors ICU correlation between treatment persistent bacteria. Methods conducted a prospective longitudinal study with urine from indwelling catheters 101 patients Uppsala University Hospital, Sweden. Samples were screened isolates confirmed MALDI-TOF whole genome sequencing. Isolates analyzed AMR using broth...

10.3389/fmed.2023.1087446 article EN cc-by Frontiers in Medicine 2023-02-07

Urinary tract infections (UTIs) are prevalent among patients carrying indwelling catheters in the intensive care unit (ICU). This study investigates antibiotic use and bacterial colonisation ICU during third wave of COVID-19 pandemic, building on our prior discovery increased

10.1080/23744235.2024.2423884 article EN cc-by Infectious Diseases 2024-11-07

Brucella is a highly pathogenic bacteria endemic in Kenya, and spite of its severity humans, the inadequate Febrile Antigen Agglutination Test (FBAT) remains primary tool for diagnosis. Blood samples were collected from febrile patients Kinna health center screened by local routine. Milk purchased milk hawkers analyzed antibodies using ring test (MRT). The MRT-positive was traced to farms, lactating cattle sampled blood. MRT-tested serum Rose Bengal (RBT) iELISA. Available patient farm...

10.3389/fitd.2021.711425 article EN cc-by Frontiers in Tropical Diseases 2021-09-21

Here, we report the complete genome sequence of a Swedish clinical strain Yersinia enterocolitica , Y72. With emerging outbreaks circulating in Nordic countries, Y72 will provide more insights on genetic relatedness and antibiotic resistance dissemination future studies.

10.1128/mra.00264-21 article EN Microbiology Resource Announcements 2021-05-12
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