A5004741751- Cardiomyopathy and Myosin Studies
- RNA Research and Splicing
- Nuclear Structure and Function
- Genomics and Chromatin Dynamics
- Congenital heart defects research
- Muscle Physiology and Disorders
Institut de Myologie
2011-2013
Sorbonne Université
2011-2013
Pitié-Salpêtrière Hospital
2011-2013
Inserm
2013
Centre de Recherche en Myologie
2013
Centre National de la Recherche Scientifique
2013
The LMNA gene encodes lamin A/C intermediate filaments that polymerize beneath the nuclear membrane, and are also found in nucleoplasm an uncharacterized assembly state. They thought to have structural functions regulatory roles signaling pathways via interaction with transcription factors. Mutations been involved numerous inherited human diseases, including severe congenital muscular dystrophy (L-CMD). We created Lmna(ΔK32) knock-in mouse harboring a L-CMD mutation. Lmna(ΔK32/ΔK32) mice...
The functional and architectural benefits of embryonic stem cells (ESC) myoblasts (Mb) transplantations into infarcted myocardium have been investigated extensively. Whereas ESC repopulated fibrotic areas contributed to myocardial regeneration, Mb exerted their effects through paracrine secretions scar remodeling. This therapeutic perspective, however, has less explored in the setting nonischemic dilated cardiomyopathies (DCMs). Our aim was compare integration efficacy committed cardiac fate...