Time-restricted feeding (TRF) limits the duration of food availability without altering diet composition and can combat obesity in humans mice. For this study we evaluated effect timing access during a TRF protocol on weight gain, adiposity, inflammation. Young male C57BL/6 mice were placed high-fat (HF) (45% fat) for 8 weeks. Food was unrestricted or restricted to 6 h per day, either first half (HF-early) second (HF-late) active phase resemble window time consumption early late day human...

Time-restricted feeding (TRF), alternate day fasting (ADF), and the dietary restriction model known as Daniel Fast (DF; a vegan/non-processed food diet plan) have garnered attention recently nutritional interventions to combat obesity. We compared effects of various models on body composition, physical performance, metabolic health in C57BL/6 mice. Sixty young male mice were assigned TRF, ADF, DF, caloric (CR), high-fat Western (HF) fed ad libitum, or standard rodent chow for eight weeks....

Erythrocytes must maintain a biconcave discoid shape in order to efficiently deliver oxygen (O2) molecules and recycle carbon dioxide (CO2) molecules. The erythrocyte is small toroidal dielectrophoretic (DEP) electromagnetic field (EMF) driven cell that maintains its zeta potential (ζ) with dielectric constant (ԑ) between negatively charged plasma membrane surface the positively adjacent Stern layer. Here, we propose also by both ferroelectric influences (chloride ion) ferromagnetic (serum...

Objective: Theacrine, a methylurate class purine alkaloid, triggers diverse pharmacologic responses, including psychostimulatory activity by modulation of adenosinergic and dopaminergic pathways. In double-blind, placebo-controlled study, theacrine increased energy, concentration, mood, while reducing fatigue. Because caffeine, methylxanthine is frequently coadministered with theacrine, we sought to determine if pharmacokinetic and/or pharmacodynamic interaction existed between caffeine....

Objective: Firefighters (FFs) involved in fire suppression have the greatest on-duty risk of cardiovascular disease (CVD), which may be caused by oxidative stress (OS). Methods: Healthy, active FFs performed a victim "search and clear" exercise involving three conditions: (1) no heat, (2) heat + antioxidant, (3) placebo. Blood samples were analyzed for OS markers glutathione (GSH), oxidized (GSSG), superoxide dismutase (SOD), catalase (CAT), advanced oxidation protein products (AOPP)....

Mounting evidence suggests diet and exercise influence learning memory (LM). We compared a high-fat, high-sucrose Western (WD) to plant-based, amylose/amylopectin blend, lower-fat known as the Daniel Fast (DF) in rats with without regular aerobic on task of spatial working (WM).Rats were randomly assigned WD or DF at 6 weeks age. Exercised (WD-E, DF-E) ran treadmill 3 times/week for 30 min while sedentary did not (WD-S, DF-S). Rats adhered these assignments 12 weeks, inclusive ab libitum...

Firefighters and military personnel are exposed to a variety of stressors. The combination mental physical stress (i.e., dual challenges [DSCs]) results in significant oxidative (OS), which may contribute cardiometabolic dysfunction. Curcumin (CUR) is an exogenous antioxidant that attenuate such OS. Fourteen trained men participated randomized, cross-over design investigate the impact CUR on markers OS resulting from DSC. or placebo was ingested three days prior to, morning of, testing. DSC...

Abstract Waldman, HS, Smith, JW, Lamberth, J, Fountain, BJ, Bloomer, RJ, Butawan, MB, and McAllister, MJ. A 28-day carbohydrate-restricted diet improves markers of cardiovascular disease in professional firefighters. J Strength Cond Res 34(10): 2785–2792, 2020—This study compared the effects a 4-week, nonketogenic, (<25% calories) (CRD) on inflammation oxidative stress firefighters (FF). Subjects ( n = 15) reported to laboratory for 2 sessions (i.e., baseline post-CRD) where blood was...

This study investigated the effects of 6 mg/day astaxanthin supplementation on markers oxidative stress and substrate metabolism during a graded exercise test in active young men. A double-blind, randomized, counterbalanced, cross-over design was used. Fourteen men (age = 23 ± 2 years) supplemented with placebo for 4 weeks, 1 week washout period between treatments. Following each period, fasting blood sample obtained to measure stress: glutathione, hydrogen peroxide, advanced oxidation...

Ingestion of ketone supplements, caffeine, and medium-chain triglycerides (MCTs) may all be effective strategies to increase blood levels the body beta-hydroxybutyrate (D-BHB). However, acute ingestion a bolus lipids oxidative stress (OS). The purpose study was investigate impact adding varying amounts MCTs coffee on D-BHB markers OS. Ten college-aged men ingested with 0, 28, 42 g MCT in randomized order. Blood samples were collected pre- as well 2 4 h postprandial analyzed for D-BHB, total...

Background: Dietary supplements purported to improve focus and "energy" often contain stimulants, which elevate both heart rate (HR) blood pressure (BP). We evaluated the safety profile of purine alkaloid methylliberine (Dynamine®) with regards resting HR, BP, respiratory (RR), body temperature (BT). Methods: 6 men (aged: 24±4) women 22±3) ingested (Dynamine®; Compound Solutions, Inc.) at 25mg (M25) 100mg (M100), caffeine 150mg (C150), M100+C150, M100 + theacrine (Teacrine®, 50mg (M100+T50),...

Abstract McAllister, MJ, Steadman, KS, Renteria, LI, Case, Butawan, MB, Bloomer, RJ, and McCurdy, KW. Acute resistance exercise reduces postprandial lipemia oxidative stress in resistance-trained men. J Strength Cond Res 36(8): 2139–2146, 2022—Acute ingestion of a high-fat meal (HFM) results significant increases triacylglycerols (TAG) markers (OS). Combined aerobic can attenuate lipemia; however, it is not clear if acute alone reduce OS. The purpose this study was to determine OS compare...

Background: Dietary supplements purported to increase circulating nitric oxide are very popular among consumers. We determined the acute impact of two novel dietary on plasma nitrate/nitrite (NOx) and nitrite alone. Methods: 20 men women (age: 24 ± 5 years) ingested different nitrate-rich (Resync Recovery Blend at 7.5 g 15 g; Resync Collagen 21 g), or placebo, four days. Fasting blood samples were obtained before 75 min following ingestion analyzed for NOx nitrite. Results: Nitrite was not...

Background: The smoking of Cannabis sativa, the marijuana plant, is increasing in popularity among young adults, even those who may be engaged regular exercise (i.e., athletes). Research has shown plant to have antioxidant and analgesic properties, but effects on oxidative stress are conflicting. purpose this study was measure blood cardio-metabolic parameters physically active men women regularly smoke marijuana. Methods: A total 43 smokers (23 ± 4 years) 22 non-smokers (24 7 years), did...

Background: Methylsulfonylmethane (MSM) is an organosulfur compound used as a dietary supplement. We determined the plasma MSM concentration following four months of oral supplementation at escalating dosages. Methods: 45 men and women (25 ± 5 years) participated in this study. Subjects were assigned to ingest either 1, 2, or 3 grams daily for 16 weeks. Blood was collected baseline weeks 4, 8, 12, analyzed using LC-MS/MS method. Results: A group (p 0.05). With regards interaction, 16,...

Time-restricted feeding (TRF) is becoming a popular way of eating in physically active populations, despite lack research on metabolic and performance outcomes as they relate to the timing food consumption relation time exercise. The purpose this study was determine if feeding/fasting after exercise training differently affects muscle flexibility response an acute bout Male C57BL/6 mice were randomized one three groups for 8 weeks. control had ad libitum access before training. TRF-immediate...

Introduction: Methylliberine and theacrine are methylurates found in the leaves of various Coffea species Camellia assamica var. kucha, respectively. We previously demonstrated that methylxanthine caffeine increased theacrine’s oral bioavailability humans. Methods: Consequently, we conducted a double-blind, placebo-controlled pharmacokinetic study humans administered methylliberine, theacrine, to determine methylliberine’s interaction potential with either or theacrine. Subjects received an...

The bio-field array is a device that generates dielectrophoretic electromagnetic field when placed in hypotonic saline solution and direct current of approximately 3 A applied. It known cell physiology guided by bioelectrical properties, there significant growth inhibition cancerous (MDA-MB-231) cells are grown media has been reconstituted with the exposed to field, alternatively no noted noncancerous (MCF-10A) treated versus control media.To examine basis for selective human breast...

Background: Theacrine is structurally similar to caffeine, and reported improve mood cognition in human subjects.The purpose of the present study was determine impact theacrine on subjective mood, cognitive performance, Heart Rate (HR) Blood Pressure (BP).Methods: 24 men (aged: 24.3±6.1)and 26 women 23.4±3.5)ingested a placebo, (Teacrine ® , Compound Solutions, Inc.) at 25mg, 125mg, caffeine 150mg, or 125mg + 150mg five separate occasions, separated by approximately one week.HR BP were...