A5080567285- Sepsis Diagnosis and Treatment
- Pharmaceutical studies and practices
- Nutritional Studies and Diet
- Antibiotics Pharmacokinetics and Efficacy
- Acute Myocardial Infarction Research
- Asthma and respiratory diseases
- Chronic Lymphocytic Leukemia Research
- Chemical synthesis and alkaloids
- Consumer Attitudes and Food Labeling
- Cardiac Arrest and Resuscitation
- Chronic Myeloid Leukemia Treatments
- Pleural and Pulmonary Diseases
- Alkaloids: synthesis and pharmacology
- Respiratory Support and Mechanisms
- Hormonal Regulation and Hypertension
- Pregnancy and Medication Impact
- Bone health and treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Pharmacovigilance and Adverse Drug Reactions
- Pericarditis and Cardiac Tamponade
- Stress Responses and Cortisol
- Quinazolinone synthesis and applications
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- SARS-CoV-2 detection and testing
Jersey Shore University Medical Center
2024
Hackensack University Medical Center
2024
Marqués de Valdecilla University Hospital
2003-2022
Instituto de investigación sanitaria y biomédica de Alicante
2021
Hospital General Universitario de Alicante Doctor Balmis
2012-2020
Universitat de Miguel Hernández d'Elx
2015
Hospital Txagorritxu
2008-2012
Universidad de Cantabria
2004-2005
Baylor College of Medicine
1994
University of Miami
1990-1994
Background: Epidemiological studies and feeding trials with supplements suggest that fibre intake is associated a reduction in cardiovascular risk. However, the effects of changes dietary on risk factor levels have not been evaluated free-living individuals. Thus, factors were assessed over 3 months high-risk subjects. Methods: 772 subjects (age 69±5 years) assigned to low-fat diet or two Mediterranean-style diets. All participants received behavioural nutritional education, including...
Objective To evaluate the role of amino acid profiles in septic encephalopathy. Design Retrospective analysis. Setting Medical wards and medical ICU a university hospital. Patients with infections normal mental status were compared patients shock altered sensorium. Interventions Plasma levels Acute Physiology Chronic Health Evaluation (APACHE II) scores determined. Measurements Main Results sensorium had higher circulating concentrations ammonia (425 ± 55 vs. 127 7 mmol/L) aromatic acids...
The implementation of strategies to mitigate possible cases COVID-19 were addressed at the University Alicante for safe reopening 2020/2021 academic year. To discover prevalence immunity against SARS-CoV-2, a study was designed using rapid immunoassay test (carried out between 6 and 22 July 2020), in addition cross-sectional survey conducted on risk factors, symptoms, predisposition becoming vaccinated, sources information about COVID-19. A random sample, stratified by students, faculty,...
Of 41 patients with bone-related infections who were treated for > or =10 days piperacillin-tazobactam, 14 (34%) developed neutropenia. Cumulative doses of piperacillin administered to neutropenic higher than those nonneutropenic ones (330 vs. 237 g; P=.008), and an inverse correlation was detected between the absolute neutrophil count at end treatment cumulative dose (r=-0.47, P=.002). Moreover, incidence piperacillin-tazobactam-induced neutropenia increased increase in piperacillin: 0%...
Objectives: To evaluate the association between patient age and gabapentin (GBP) concentration-to-dose ratio by a multivariate analysis. Methods: The trough steady-state serum concentration of normalized to 1 mg/kg body weight or (CDR) was retrospectively assessed analysis covariance. Potential confounding factors considered were GBP dosage, number doses per day, presence concomitant antiepileptic drugs (AEDs). Concentrations that had been measured in predose "trough" samples collected from...
Background Reliable securement of nasally inserted enteral tubes is a problem in patients with facial burns that make use traditional adhesive tape ineffective. Objective To implement the nasal bridle as way to decrease inadvertent removal and improve subsequent patient outcomes. Methods The was implemented burn unit University Kansas Hospital, City, Kansas, quality improvement project. Outcomes for calendar year 2010 were measured treated before (prebridle control group) whom used. groups...
To report and discuss a serious cutaneous adverse reaction in child who was treated with acetaminophen (paracetamol).A five years old male presented pruriginous maculopapular rash "drug-induced Stevens-Johnson syndrome/Toxic Epidermal Necrolysis" suspected. Applying Spanish Pharmacovigilance System probability algorithm (modified Karch-Lasagna algorithm) for the suspected drugs (acetaminophen, ibuprofen azithromycin), causality of this possible unlikely other two drugs. In case it...
Budesonide has a long history as intranasal drug, with many marketed products. Efforts should be made to demonstrate the therapeutic equivalence and safety comparability between them. Given that systemic availability significantly varies from formulations, clinical of diverse products comes interest regulatory requirement. The aim present study was compare availability, pharmacodynamic effect, two budesonide formulations for treatment rhinitis. Eighteen healthy volunteers participated in...
Imatinib is indicated for treatment of CML, GIST, etc. The population pharmacokinetics (popPK) imatinib in patients under long-term are reported literature. Data obtained from bioequivalence trials healthy subjects were used to evaluate the influence demographic and pharmacogenetic factors on (PK) a collective without concurrent drugs, organ dysfunction, inflammation In addition, differences PK between patient cohort was examined identify possible disease effects.26 volunteers administered...
Despite the increase in substitution of branded medicinal product with generic drugs, this is a controversial issue for some pharmacological groups (such as contraceptives).The aim present clinical trial was to assess bioequivalence and tolerability two oral formulations desogestrel.Thirty-three healthy female volunteers participated randomized two-way crossover study. During separate experimental periods, at least four weeks washout period, women received single dose 75 μg desogestrel from...
We sought to determine whether there might be acute changes in hemodynamics attributable HA-1A, a monoclonal antibody endotoxin, patients with presumed Gramnegative sepsis. Design: Post hoc analysis of multicenter, randomized, double-blind, placebo-controlled study. Patients: A total 543 severe sepsis caused by Gram-negative bacteria who were enrolled clinical trial evaluate the efficacy and safety HA-1A human antibody. Interventions: Patients randomly assigned receive either 100 mg or...
Desoxypeganine (DOP) is a natural alkaloid that has been characterized as cholinesterase inhibitor and selective of monoamine oxidase A. DOP investigated for its potential utility in the pharmacological treatment alcohol abuse smoking cessation aid. The aim this clinical trial was to evaluate tolerance single-dose pharmacokinetic profile healthy human volunteers. study an open-label, dose-escalation, phase I involving administration increasing single oral doses (50, 100, 150 200 mg)....