A5053987860- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Immune cells in cancer
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- RNA Research and Splicing
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
Zhengzhou University
2022-2023
Cancer immunotherapy is an increasingly successful strategy for treating patients with advanced or conventionally drug-resistant cancers. T cells have been proved to play important roles in anti-tumor and tumor microenvironment shaping, while these not explained lung squamous cell carcinoma (LUSC). In this study, we first performed a comprehensive analysis of single-cell RNA sequencing (scRNA-seq) data from the gene expression omnibus (GEO) database identify 72 T-cell marker genes....
N6-Methyladenosine-related long noncoding RNAs play an essential role in many cancers' development. However, the relationship between m6A-related lncRNAs and acute myelogenous leukemia (AML) prognosis remains unclear. We systematically analyzed association of with tumor immune microenvironment (TME) features using therapeutically applicable research to generate effective treatment (TARGET) database. screened 315 associated AML identified nine key m6A by LASSO Cox analysis. A model was...
Immunotherapy has changed the therapeutic landscape of cervical cancer (CC), but durable anti-tumor activity only in a subset patients. This study aims to comprehensively analyze tumor immune microenvironment (TIME) CC and mine biomarkers related immunotherapy prognosis. The Cancer Genome Atlas (TCGA) data was utilized identify heterogeneous subtypes based on survival-related cell signatures (ICSs). ICSs prognostic model constructed by Cox regression analyses, immunohistochemistry conducted...
Accumulating evidence substantiated that the immune cells were intricately intertwined with prognosis and therapy of clear cell renal carcinoma (ccRCC). We aimed to construct an signatures (ICS) score model predict ccRCC patients furnish guidance for finding appropriate treatment strategies.Based on The Cancer Genome Atlas (TCGA) database, normalized enrichment (NES) 184 ICSf was calculated using single-sample gene set analysis (ssGSEA). An ICS generated in light univariate Cox regression...
Immune genes play an important role in the development and progression of acute myeloid leukemia (AML). However, immune prognosis microenvironment AML remains unclear. In this study, we analyzed 151 patients TCGA database for relevant cell infiltration. were divided into high low infiltration clusters based on ssGSEA results. Immune-related pathways, pathways glucose metabolism enriched cluster. Then screened differential between two clusters. Nine prognostic finally identified train set by...