A5028595151- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Risk Factors
- Health Promotion and Cardiovascular Prevention
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Cardiac Ischemia and Reperfusion
- HIV/AIDS drug development and treatment
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- HIV, Drug Use, Sexual Risk
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Heart Failure Treatment and Management
- Ferroptosis and cancer prognosis
- Cardiac Fibrosis and Remodeling
- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Hepatitis B Virus Studies
- Acute Myocardial Infarction Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Nutritional Studies and Diet
- Air Quality and Health Impacts
- Advanced Glycation End Products research
Zhengzhou University
2022-2025
China Three Gorges University
2016-2025
Yichang Central People's Hospital
2015-2024
Wuhan University
2022
Renmin Hospital of Wuhan University
2022
Ningbo Medical Center Lihuili Hospital
2021
Yunnan Center for Disease Control And Prevention
2008-2021
Second Hospital of Yichang
2020-2021
Kunming University of Science and Technology
2021
University of Sindh
2021
We aimed to describe the trends in prevalence, intervention, and control of metabolic syndrome (MetS) among US adults through 1999-2018. Additionally, influence factors MetS its were further explored.We included participants older than 20 using National Health Nutrition Examination Survey (NHANES) from 1999 2018 (n = 22,114). The rate caculated by survey weights. Joinpoint regression survey-weighted generalized linear models used analyze factors, respectively.The prevalence increased 28.23...
Abstract Background Researches have found that alteration of intestinal flora may be closely related to the development autism spectrum disorder (ASD). However, whether probiotics supplementation has a protective effect on ASD remains controversial. This meta-analysis aimed analyze outcome in treatment children. Methods The Pubmed, Cochrane Library, Web Science and Embase were searched until Sep 2022. Randomized controlled trials (RCTs) relevant placebo children screened. Quality assessment...
The link between cardiometabolic markers and hepatic steatosis liver fibrosis in non-hypertensive, non-diabetic populations remains unclear. A study was conducted using data from the National Health Nutrition Examination Survey. Hepatic were assessed vibration-controlled transient elastography. Logistic regression restricted cubic splines (RCS) used to evaluate associations of index (CMI), atherogenic plasma (AIP), triglyceride-glucose (TyG), estimated glucose disposal rate (eGDR) on...
Background: Myocardial apoptosis is heavily implicated in the myocardial damage caused by ischemia-reperfusion (I/R). Toll-like receptor 4 (TLR4) a potent inducer of these apoptotic cascades. In contrast, radioprotective 105 kDa protein (RP105) specific negative regulator TLR4 signaling pathways. However, precise mechanisms which RP105 inhibits myocardium via TLR4-associated pathways during I/R not fully understood. Methods: We utilized rat model ischemic reperfusion injury (MIRI). Animals...
Abstract Apoptosis is the major cause of cardiomyocyte death in myocardial ischemia/reperfusion injury (MI/RI). Increasing evidence suggests that microRNAs (miRNAs) can contribute to regulation cardiomyocytes apoptosis by posttranscriptional modulation gene expression networks. However, effects miR‐327 regulating MI/RI‐induced have not been extensively investigated. This study was performed test whether participate both vitro and vivo, reveal potential molecular mechanism regulated MI/RI...
Cancer immunotherapy is an increasingly successful strategy for treating patients with advanced or conventionally drug-resistant cancers. T cells have been proved to play important roles in anti-tumor and tumor microenvironment shaping, while these not explained lung squamous cell carcinoma (LUSC). In this study, we first performed a comprehensive analysis of single-cell RNA sequencing (scRNA-seq) data from the gene expression omnibus (GEO) database identify 72 T-cell marker genes....
Yunnan has been severely affected by HIV/AIDS in China. Recently, the reported prevalence of HIV-1 among men who have sex with (MSM) was high To monitor dynamic epidemic MSM, genetic characteristics and transmitted drug resistance (TDR) were investigated.Blood samples from 131 newly diagnosed MSM continuously collected at fixed sites January 2010 to December 2012 Kunming City, Province. Partial gag, pol env genes sequenced. Phylogenetic, evolutionary genotypic analyses performed.Multiple...
Background Yunnan has the longest endured Human Immunodeficiency Virus-1 (HIV-1) epidemic in China, and genetic diversity of HIV-1 constitutes an essential characteristic molecular epidemiology this region. To obtain a more comprehensive picture dynamic changes Yunnan's epidemic, cross-sectional epidemiological investigation was carried out among recently infected individuals. Methodology/Principal Findings We sequenced partial gag (HXB2∶781–1861) env (HXB2∶7002–7541) genes from 308 plasma...
Previous studies have reported that microRNA-22 (miR-22) may be implicated in ischemia-reperfusion (I/R)-induced myocardial injury. Our previously published data also demonstrated miR-22 protect against I/R injury via anti-apoptosis rats by targeting cAMP response element-binding protein binding (CBP). However, the specific function of is far from fully elucidated. The present study was designed to investigate another cardioprotective signaling mechanism A total 40 adult male Sprague-Dawley...
Background Yunnan has the greatest share of reported human immunodeficiency virus (HIV)/acquired syndrome (AIDS) cases in China. In recent years, HIV prevalence and incidence remained stubbornly high men who have sex with (MSM). To follow dynamics HIV-1 epidemic among MSM, genetic characteristics transmission networks were investigated. Methods Blood samples from 190 newly diagnosed MSM continuously collected at fixed sites January 2013 to December 2015 Kunming City, Province. Partial gag,...
Micro RNAs (miRNAs) play a very important role in myocardial ischemia/ reperfusion injury (MIRI), including inflammation, apoptosis, and angiogenesis. Previous studies have demonstrated up-regulation of miR-327 renal ischemia/reperfusion MIRI. Via TargetScan, we found RP105 is possible target gene miR-327; our previous also confirmed that acted as cardioprotective protein MIRI by reducing inflammation. However, the regulatory effect on has not previously been proposed. In study, aimed to...
Oxidative stress is strongly implicated in the pathogenesis of myocardial damage caused by ischemia reperfusion (I/R). Previous studies have confirmed that cardiac CD47 drives left ventricular heart failure. However, role for I/R injury (MIRI) has not previously been proposed. This study was designed to investigate whether down-regulation using RNA interference (RNAi) technology can relieve inhibition nitric oxide signaling and attenuate a rat model I/R.Male Sprague-Dawley rats (n = 40) were...
The long-term stimulation of hyperglycemia greatly increases the incidence vascular restenosis (RS) after angioplasty. Neointimal hyperplasia injury is pathological cause RS, but its mechanism has not been elucidated. MicroRNA-24 (miR-24) low expression in injured carotid arteries diabetic rats. However, role miR-24 system unknown. In this study, we explore whether over-expression could attenuate neointimal formation streptozotocin (STZ)-induced Adenovirus (Ad-miR-24-GFP) was used to deliver...
As a gateway for HIV-1 in China, Yunnan has experienced dramatic changes epidemics, during which genotypes have become complex. To track dynamic genotypes, an molecular epidemiological study was implemented the recently infected population Yunnan.From 6,357 HIV-1-positive samples diagnosed first half of 2015 Yunnan, 586 were identified as recent infections with BED-capture enzyme immunoassay (CEIA) and subjected to phylogenetic analyses. Spatial scanning analyses main also performed.Among...
The intake of antioxidant vitamins can scavenge free radicals and reduce oxidative stress, which may be beneficial for stroke. However, the relationship between total capacity (TAC) stroke is controversial. This study aims to investigate association dietary TAC risk in US adults. included participants over 20 years old from 2001-2018 National Health Nutrition Examination Survey (NHANES). Data two 24 h recalls were used estimate usual vitamins. was calculated by vitamin C equivalent reference...
Abstract Aims Previous studies investigated the associations between sleep traits and cardiac diseases, but evidence for causal inferences was unclear. This study aimed to explore relationship diseases by virtue of Mendelian randomization (MR). Methods results Summary‐level data exposure variables (sleep duration, chronotype, insomnia) outcome (ischaemic heart disease, atrial fibrillation, myocardial infarction, failure) were derived from UK Biobank. Data FinnGen consortium used as a...
Objective We aimed to describe the trends and influence factors in prevalence, awareness, treatment, control of hypertension among US Adults from 1999 2018. Methods utilized data National Health Nutrition Examination Survey (NHANES) spanning ten survey cycles (n = 53,496). Prevalence, were calculated using weights. Joinpoint regression survey-weighted generalized linear models used analyze factors, respectively. Results The estimated prevalence increased significantly 33.53% 40.58% (AAPC...
To investigate the prevalence and associated risk factors of human immunodeficiency virus (HIV), hepatitis B (HBV) sexually transmitted infections (STIs) among men who have sex with (MSM) in Kunming, 300 MSM were recruited through community-based organizations between September 2014 January 2015. The HIV, HBsAg, syphilis, Chlamydia trachomatis (CT) Neisseria gonorrhoeae (NG) 17.0%, 7.7%, 11.3%, 18.2% 13.2%, respectively. In three different anatomic sites (urethra, rectum pharynx), rectal CT...
Abstract Multiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered Yunnan Province before disseminating throughout the country. As HIV-1 epidemic continues to expand Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among recently infected population. Among 2828 HIV-positive samples newly reported quarter of 2014, 347 identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291...