A5075304112- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Nuclear Physics and Applications
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Boron Compounds in Chemistry
- Neuroendocrine Tumor Research Advances
- HER2/EGFR in Cancer Research
- Particle accelerators and beam dynamics
- Cancer, Hypoxia, and Metabolism
- Chemical Reactions and Isotopes
- Radioactive element chemistry and processing
- Lanthanide and Transition Metal Complexes
- Trace Elements in Health
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Radioactive Decay and Measurement Techniques
- Radiomics and Machine Learning in Medical Imaging
- Radioactive contamination and transfer
- Radiation Therapy and Dosimetry
- CAR-T cell therapy research
- Nuclear physics research studies
- Muon and positron interactions and applications
- Lung Cancer Research Studies
University of Alabama at Birmingham
2016-2025
O'Neal Comprehensive Cancer Center
2024
Twitter (United States)
2023
Hospital Maciel
2023
Washington University in St. Louis
2011-2020
Advanced Imaging Research (United States)
2020
University of Alabama
2016-2020
Mallinckrodt (United States)
2009-2017
Birmingham VA Medical Center
2016
Office of Science
2016
Cd/CB-induced citrullinated vimentin promotes PAD2- and TLR4-dependent lung fibrosis.
Manganese-52 is gaining interest as an isotope for PET imaging due to its desirable decay and chemical properties radiopharmaceutical development. Somatostatin receptor 2 (SSTR2) significantly overexpressed by neuroendocrine tumors (NETs) important target nuclear therapy. As agonist, [68Ga]Ga-DOTATATE has demonstrated significant internalization upon interaction with ligands, whereas [68Ga]Ga-DOTA-JR11(as antagonist) exhibits limited but better pharmacokinetics increased tumor uptake. The...
We investigated the effects of copper (Cu) and iron (Fe) availability on growth rates, cellular Cu content, steady‐state uptake rates eight species centric diatoms (coastal oceanic strains). Whereas Fe had a significant effect both costal diatoms, an interaction between was only observed for diatoms. Determination : carbon (C) quotas using radiotracers 67 14 C revealed that under Cu‐sufficient conditions elevated :C ratios relative to coastal strains, regardless availability. Two (one one...
Pertuzumab is a monoclonal antibody that binds to HER2 and used in combination with another HER2-specific antibody, trastuzumab, for the treatment of HER2+ metastatic breast cancer. an binding site distinct from its affinity enhanced when trastuzumab present. We aim exploit this pertuzumab epitope adapt as PET imaging agent by radiolabeling (89)Zr increase sensitivity detection vivo. Here, we investigate biodistribution (89)Zr-pertuzumab HER2-expressing BT-474 HER2-nonexpressing MDA-MB-231...
Thyroid cancer is the most common endocrine cancer, with differentiated thyroid cancers (DTCs) accounting for 95% of diagnoses. While DTC patients are diagnosed and treated radioiodine (RAI), up to 20% become RAI refractory (RAI-R). RAI-R have significantly reduced survival rates compared who remain RAI-avid. This study explores [89Zr]Zr-TR1402 as a thyroid-stimulating hormone receptor (TSHR)-targeted PET radiopharmaceutical DTC. was synthesized molar activity 25.9 MBq/nmol by conjugating...
Prostate-specific membrane antigen (PSMA) is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer well-known imaging biomarker for staging monitoring therapy. Although <sup>111</sup>In-labeled capropmab pendetide only approved agent available PSMA imaging, its clinical use limited because slow distribution clearance that leads to challenging image interpretation. A small-molecule approach using radiolabeled urea-based inhibitors as agents has...
The human epidermal growth factor receptor 2 (HER2/neu) is overexpressed in 20–30% of breast cancers and associated with tumor growth, angiogenesis, development distant metastases. Trastuzumab, an anti-HER2 monoclonal antibody, used for the treatment HER2 positive cancer clinical efficacy this agent dependent on expression. Targeted PET imaging radiolabeled trastuzumab may be to determine expression levels guide therapy selection. purpose current study was evaluate a facile 89Zr-trastuzumab...
The epidermal growth factor receptor (EGFR) is overexpressed in the majority of malignancies and has been associated with poor outcomes. Panitumumab, an anti-EGFR monoclonal antibody that binds to extracellular binding domain EGFR, increasingly used radiotherapy chemotherapy but toxicities. purpose this study was develop characterize a novel targeted imaging agent for EGFR using radiolabeled panitumumab. Flow cytometry studies were performed evaluate expression several cell lines....
The Facility for Rare Isotope Beams (FRIB) at Michigan State University provides a unique opportunity to access some of the nation's most specialized scientific resources: radioisotopes. An excess useful radioisotopes will be formed as FRIB fulfills its basic science mission providing rare isotope beams. In order beams reach high-purity, many isotopes are discarded and go unused. If harvested, unused could enable cutting-edge research diverse applications ranging from medical therapy...
Theranostic strategies involve select radionuclides that allow diagnostic imaging and tailored radionuclide therapy in the same patient. An example of a Food Drug Administration–approved theranostic pair is <sup>68</sup>Ga- <sup>177</sup>Lu-labeled DOTATATE peptides, which are used to image neuroendocrine tumors, predict treatment response, treat disease. However, when using 2 different elements, differences pharmacokinetic pharmacodynamic profile agent can occur. agents incorporate...
Triple-negative breast cancers (TNBCs) currently have limited treatment options; however, PD-L1 is an indicator of susceptibility to immunotherapy. Currently, assessment biopsy samples. These limitations may be overcome with molecular imaging. In this work, we describe chemistry development and optimization, in vitro, vivo, dosimetry [89Zr]-Atezolizumab for Atezolizumab was conjugated DFO radiolabeled 89Zr. Tumor uptake heterogeneity TNBC xenograft patient-derived (PDX) mouse models were...
One of the most aggressive forms breast cancer involves overexpression human epidermal growth factor receptor 2 (HER2). HER2 is overexpressed in ∼25% all cancers and associated with increased proliferation, rates metastasis, poor prognosis. Treatment for HER2-positive has vastly improved since development monoclonal antibody trastuzumab (Herceptin) as well other biological constructs. However, patients still commonly develop resistance, illustrating need newer therapies. Nanobodies have...