A5066482521- Fullerene Chemistry and Applications
- Ultrasound and Hyperthermia Applications
- Drug-Induced Hepatotoxicity and Protection
- Electrospun Nanofibers in Biomedical Applications
- Thermal Regulation in Medicine
- Tissue Engineering and Regenerative Medicine
- Sirtuins and Resveratrol in Medicine
- Biochemical Acid Research Studies
- Boron and Carbon Nanomaterials Research
- Anesthesia and Neurotoxicity Research
- Food Industry and Aquatic Biology
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Bee Products Chemical Analysis
- Carbon Nanotubes in Composites
- 3D Printing in Biomedical Research
- Cardiac electrophysiology and arrhythmias
- Periodontal Regeneration and Treatments
- Scientific Research and Studies
- Chemical Reactions and Isotopes
- Pancreatic function and diabetes
- Bone fractures and treatments
- Electron Spin Resonance Studies
- Mesenchymal stem cell research
- Polymer Nanocomposite Synthesis and Irradiation
Institute for Problems of Cryobiology and Cryomedicine
2010-2024
National Academy of Sciences of Ukraine
2010-2024
Kharkiv Institute of Physics and Technology
2010
Current regimens for the eradication of Helicobacter pylori infection include bismuth drugs, proton pump inhibitors, and a combination 2–3 antibacterial drugs. Uncontrolled use agents as part schemes increases risk developing their unwanted drug reactions, in particular, hepatotoxicity. As means with potentially hepatoprotective activity, our attention was drawn to placental cryoextract.
 The purpose study. To characterize gender aspects hepatotropic action placenta cryoextract...
Background. Viral hepatitis is one of the most common and dangerous diseases in world third infectious disease. The development new, more effective safer hepatoprotective drugs an urgent task biomedicine. A wide range proven biological properties cryoextract human placenta, particular presence antioxidant, immunomodulating anti-inflammatory effects, suggests that it has a effect. model D-galactosamine toxic hepatitis, which similar to viral terms morphological biochemical changes liver, was...
The purpose of the work was to reveal role sex factors in processes lipid peroxidation (LPO) against background chronic ethanol-tetrachloromethane-induced liver damage and hepatotropic effects triple antiulcer therapy cryopreserved placenta extract (CEP). Chronic induced by introduction a CCl4 solution combination with an ethanol for 45 days. content reactants thiobarbituric acid (TBA-active products) catalase activity were measured homogenates. Modulation hormones achieved surgical...
Background. Determining the impact of sympatho-adrenal system on morpho-functional state heart in acute coronary syndrome is a relevant task today. On other hand, an important objective to study dynamics changes heart’s functional processes under influence biologically active substances as alternative treatments for muscle tissue, aiming accelerate reparative regeneration myocardium after epinephrine-induced damage. Purpose – focuses ultrasound indicators conditions experimental myocardial...
Non-steroidal anti-inflammatory drugs are among the top requested ones in clinic of internal medicine. However, these associated with a wide range adverse reactions involving number organs and systems, particular gastrointestinal tract, cardiovascular system kidneys. The aim study is to characterize effect combined use cryopreserved placenta extract diclofenac sodium on prooxidant-oxidative system, activity inflammatory, destructive cytolytic processes, as well protein lipid metabolism rats...
Background. At the present stage of oncology development, cryosurgery is keeping up with other surgical options treating malignant tumors. However, especially when using cryoapplication technique, radical low-temperature destruction large tumors challenged uneven freezing tissue inside and on periphery cryoablation zone resulting in insufficient complete all tumor cells. The long-term strategy increasing efficiency cryogenic treatment, which will maximize potential for exposure biological...
Background. Peptic ulcer is a prevalent gastrointestinal tract disease worldwide. One of the treatment methods for indicated pathology trunk gastric cryodenervation (TGC), feature which preservation regenerative potential n. vagus. Cryopreserved placenta extract (CPE) caught our attention among modern means capable stimulating regeneration processes. Objective. We are aimed to characterize state secretion after TGC and application СPE. Methods. was performed by cryoinfusion on front back...
We studied the ultrastructural changes in cardiomyocytes during necrosis development and re-modelling of rat heart following experimental myocardial infarction (MI) performing therapeutic hypothermia administration allogeneic mesenchymal stromal cells (MSCs). The was provoked via ligation left coronary artery. Therapeutic performed cold chamber for 60 min achieving 4°C skin temperature collar zone. suspension cryopreserved MSCs placenta with 1.2x10° cells/ml concentration intravenously...
Background. Late seeking medical advice, limited number of cardiac surgery hospitals and conservative treatment, which does not seem to be always efficacious, trigger the search for new, more effective mode therapy acute myocardial infarction (MI). Recently, mesenchymal stromal cells (MSCs) have come into sharp focus scientists due prospects clinical use. On other hand, multicenter studies proved that therapeutic hypothermia (TH) has neuro- cardioprotective effects, it is administered as one...
Background. The issue of stimulating reparative myocardial regeneration in ischemic heart disease (IHD) is a pressing one, requiring in-depth experimental and clinical research. Consequently, considerable attention currently being paid to studies on the effectiveness mechanisms action regenerative plastic therapy for pathological conditions cardiovascular system. To prevent cardiac aneurysms early post-infarction period treat progressive chronic failure, biodegradable polymer hydrogels,...
The effect of C60 fullerene aqueous colloid solution (C60 FAS) on activity redox and proliferative processes in PKE (transplantable cell line pig kidney embryo) cells has been studied. In particular, it was established that the presence (127 microM) culturing medium during 48 h did not change their ability to reduce non-toxic AlamarBlue indicator activity.
Background. Diseases of cardiovascular system still occupy the first place among causes death and disability population. Currently new methods for stimulating regeneration damaged myocardium are actively developing. It is assumed that transplantation mesenchymal stromal cells (MSCs) can promote replacement necrotic areas by newly formed cardiomyocytes stimulate angiogenesis in ischemic area. In last decade method application therapeutic hypothermia order to protect heart brain from oxygen...
Вплив водного колоїдного розчину фулерену C 60 на гематологічні і біохімічні показники крові щурів О.О.Власов 1,2 , Г.О.Ковальов 1 І.В.Бєлочкіна І.А
Background. Development and improvement of methods treating patients with a mine-blast trauma (MBT) involves the experiments animals. A particular way to simulate MBT in vivo determines nature range injury severity as well their possible regulation. Objective. Morphological evaluation rat femoral tissue injuries following depending on powder charge energy availability strike elements. Methods. The modelling was done cartridge-operated guns. inflicted wounds were histologically studied at 7th...
Цель. Создание доступной модели минно-взрывной травмы различной степени тяжести у крыс. Материалы и методы. Взрывное повреждение мягких тканей бедра крыс моделировали с помощью строительно-монтажного пистолета (СМП) специально разработанной стойки, которая обеспечивала фиксацию СМП во время выстрела. Для имитации повреждения от поражающих элементов в стволе размещали стальные осколки. Результаты. Макроскопическая оценка повреждений показала, что они имеют признаки, характерные для поражения...