Current regimens for the eradication of Helicobacter pylori infection include bismuth drugs, proton pump inhibitors, and a combination 2–3 antibacterial drugs. Uncontrolled use agents as part schemes increases risk developing their unwanted drug reactions, in particular, hepatotoxicity. As means with potentially hepatoprotective activity, our attention was drawn to placental cryoextract.
 The purpose study. To characterize gender aspects hepatotropic action placenta cryoextract...

Aiming to reduce the potential in vivo hepato-and nephrotoxicity of Ag/Au bimetallic nanoparticles (NPs) stabilized by sodium dodecyl sulphate (SDS), an approach involving a simultaneous reduction silver nitrate and tetrachlorauratic acid using tryptophan (Trp) as reducing/stabilizing agent was applied during NP synthesis. The obtained Ag/Au/Trp NPs (5–15 nm sized) were able form stable aggregates with average size 370–450 potentially less toxic than Ag/Au/SDS relation mouse model system...

Abstract The possibility of using RAS waste water as a cultivation medium for Desmodesmus armatus (Chod.) Hegew. was investigated. Algal biomass increased continuously reaching its maximum on the day 40 cultivation. D. culture characterized by content total proteins 23% At same time, 17 proteinogenic amino acids, including 9 replaceable and 8 essential were detected identified in biomass. Among these contents asparagine glutamine noted. A gradual increase number photosynthetic pigments until...

The literature indicates that retinoids can influence the metabolism and actions of xenobiotics conversely retinoids. We were interested in understanding degree to which hepatic retinoid stores, accumulated over a lifetime, affect xenobiotic metabolism, actions. To investigate this, we induced liver injury through administration hepatotoxin thioacetamide (TAA) chow fed wild type (WT) mice lecithin:retinol acyltransferase-deficient (Lrat−/−) are genetically unable accumulate stores. Within 48...

Abstract The possibility of using carotenogenic yeast from the genus Rhodotorula as food substrate was studied during cultivation Moina macrocopa. results showed that replacing traditional substrates live fish M. macrocopa resulted in improved characteristics were superior to alternative. Using glutinis (Fres.) Harrison stimulate carotenoid accumulation feed is better than R. rubra (Demme) Lodder. optimal duration enriching with carotenoids four days when various types capable...

Derivatives of 2(5H)-furanone (γ-crotonolactone) are important intermediate synthetic products with a wide range biological effects that have become widely used in the pharmaceutical industry, medicine, and veterinary particular prevention treatment fish diseases. However, environmental issue obtaining these compounds while reducing negative impact on surrounding environment remains relevant. This article describes for first time method γ-crotonolactone synthesis is based concept green...

Diethyl phthalate (DEF) is a synthetic chemical widely used as plasticizer and additive in personal care pharmaceutical products. Low-dose exposure to this xenobiotic over long period contributes its intake into the human body high doses. To date, studies of DEF influence on free radical processes liver cells, which it not only metabolized but can also have prooxidant effect, remain limited. The aim our research was determine ROS formation, intensity oxidative modification proteins (OMP)...

Background/Aim: Drug-induced liver injury is one of the major causes acute failure. Under current circumstances pandemic COVID-19, use paracetamol which has a proven hepatotoxic effect increased. This prompts search for novel agents with hepatoprotective properties. The purpose this article was to evaluate activity cryoextract placenta (CEP) on model paracetamol-induced hepatitis. Methods: study performed 28 male rats. Acute drug damage modelled by intragastric administration twice at dose...

The effect of diet supplementation with polyunsaturated fatty acids (PUFAs) used at different ratios w-6/w-3 was studied on the content primary (diene conjugates, DC; triene TC), secondary (ketodienes, CD; coupled trienes, CT; TBA-active products) and terminal (Schiff bases) lipid peroxidation products (LPO) generation superoxide anion-radical in rat heart mitochondrial fraction. It shown that high doses w-6 or w-3 PUFAs increased primary, LPO Llipid accompanied by intensification During...

The results of using the waste water from recirculating aquaculture system for phyto- and zooplankton cultivation are presented in article. physico-chemical parameters system’s comparative culture media were recorded during hydrobionts cultivation. indicators productivity biochemical composition investigated cultures determined. analysis studied included investigations content total proteins, lipids, carbohydrates, carotenoids photosynthetic pigments. Using as a medium can significantly...

The activity of detoxication enzymes in liver microsomal fraction preliminary radiation-exposed rats was investigated. It shown that organism exposure to radiation reduced cytochrome Р450 and glutathione-S-transferase the latent logarithmic phases oncogenesis compared with unirradiated tumor.Low level can be caused by transition P450 P420 inactive form.The does not influence enzyme on terminal stages Guerin's carcinoma growth.

Hepatoprotective activity of Nuclex, a pharmaceutical composed low-molecular yeast RNA, was investigated during acute and chronic thioacetamide-induced hepatotoxicity. It is demonstrated, that Nuclex administration at dose 200 mg/kg liver injury produces hepatoprotective effect, which associated with decrease in parenchyma lesions its inflammatory infiltration. application attenuates free radical damage hepatic biopolymers, expressed the reduction TBA-reactive products, carbonyl derivatives,...

The effect of low-level irradiation tumor-bearing rats on the structural and functional organization cytochrome part respiratory chain mitochondria isolated from Guerin's carcinoma has been investigated. maximal reduction in mitochondrial cytochromes a, b c content was observed at terminal stage carcinoma. A during initial stages oncogenesis produced opposite changes content. possible mechanism haem-containing may be attributed to impairment their formation caused by inhibition key enzyme...

Classical xenoestrogenic in vivo effects of bisphenol A (2,2-bis(4-hydroxyphenyl)propane, BPA) are well-described the literature, however molecular mechanisms BPA-induced hepatotoxicity not fully characterized. The work is aimed to assess biochemical markers BPA induced under conditions differential supplementation with retinoids. We demonstrate that absence hepatic retinyl esters as main form vitamin storage provides for a resistance liver damage. Retinoid increases hepatotoxic A, evidenced...

Background. Peptic ulcer is a prevalent gastrointestinal tract disease worldwide. One of the treatment methods for indicated pathology trunk gastric cryodenervation (TGC), feature which preservation regenerative potential n. vagus. Cryopreserved placenta extract (CPE) caught our attention among modern means capable stimulating regeneration processes. Objective. We are aimed to characterize state secretion after TGC and application СPE. Methods. was performed by cryoinfusion on front back...

The results of using the waste water from recirculating aquaculture system for phyto- and zooplankton cultivation are presented in article. physico-chemical parameters system’s comparative culture media were recorded during hydrobionts cultivation. indicators productivity biochemical composition investigated cultures determined. analysis studied included investigations content total proteins, lipids, carbohydrates, carotenoids photosynthetic pigments. Using as a medium can significantly...

Abstract The first aim of the study was to determine impact commercial product S.presso (INVE Aquaculture, Belgium) had on enriching proximate composition brine shrimp (Artemia sp.). second develop a better enrichment protocol for preparing enriched larvae. Two different protocols were investigated; supplement administered in either one (0.5 g L -1 ) or two equal (0.25 doses. Using enrich nauplii with polyunsaturated fatty acids resulted higher levels total lipids and quantities...

The analysis of literature sources on the question relevance influence raw milk and its casein fraction production rennet cheeses is presented in paper. studies were conducted to determine suitability using for from materials cows Ukrainian brown dairy black-rumped breeds state enterprise “Research Institute Agriculture North East NAAS”. As a result cheesiness samples two study groups, we can conclude that, compared data, average values obtained black-and-white are confirmed. While analyzing...