The future of innovative robotic technologies and artificial intelligence (AI) in pharmacy medicine is promising, with the potential to revolutionize various aspects health care. These advances aim increase efficiency, improve patient outcomes, reduce costs while addressing pressing challenges such as personalized need for more effective therapies. This review examines major robotics AI pharmaceutical medical fields, analyzing advantages, obstacles, implications In addition, prominent...

A series of novel hydrazones bearing diphenylamine and 5-oxopyrrolidine moieties, along with benzene naphthalene rings substituted hydroxy, alkoxy, or carboxylic groups, were synthesized. Their anticancer activity was evaluated in vitro using both 2D (MTT ‘wound healing’ assays) 3D (cell spheroid) models against human melanoma IGR39 cells, the triple-negative breast cancer cell line MDA-MB-231, pancreatic carcinoma Panc-1 line. Compounds 8 (2-hydroxybenzylidene derivative) 12...

A series of new 1,4-naphtho- and benzoquinone derivatives possessing N-, S-, O-substituted groups which has not been reported yet synthesized from 2,3-dichloro-1,4-naphthoquinone 1 2,3,5,6-tetrachlorocyclohexa-2,5-diene-1,4-dione 15 involving a Michael addition. In the compounds, antimicrobial activity at low concentrations against Escherichia coli B-906, Staphylococcus aureus 209-P, Mycobacterium luteum B-917 bacteria Candida tenuis VKM Y-70 Aspergillus niger F-1119 fungi in comparison with...

Anticancer activity as an associated action for a series of dithiocarbamates 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The cytotoxic dithiocarbamate derivatives evaluated in vitro on cancer cells human lung (A549), prostate (PC3), colon (HT29) breast (MCF7) sulforhodamine B (SRB) cell viability assay. Among these compounds, 9,10-dioxo-9,10-dihydroanthracen-1-yl pyrrolidin-1-carbodithioate 9,10-dioxo-9,10-dihydroanthracen-2-yl...

Abstract Telomerase reactivation is one of the hallmarks cancer, which plays an important role in cellular immortalization and development progression tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence apoptotic cell death both vitro vivo. Due its upregulation various cancers, considered a potential target cancer therapy. In this study, we identified potent, small-molecule using repeat amplification protocol assay. The results assay are first evidence...

The development and spread of resistance human pathogenic bacteria to the action commonly used antibacterial drugs is one key problems in modern medicine. One especially dangerous easily developing antibiotic resistant bacterial species Staphylococcus aureus. Anthra[1,2-d][1,2,3]triazine-4,7,12(3H)-triones 22-38 have been developed as novel effective antistaphylococcal agents. These compounds obtained by sequential conversion 1-amino-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid (1)...

Potent Inhibitors for Receptor Tyrosine KinasesThe influence of new derivatives 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity membrane-associated tyrosine kinases was investigated.Inhibitors protein kinase membrane fraction, as promising agents to search potential anticancer among studied compounds, were discovered.

Derivatives of 2(5H)-furanone (γ-crotonolactone) are important intermediate synthetic products with a wide range biological effects that have become widely used in the pharmaceutical industry, medicine, and veterinary particular prevention treatment fish diseases. However, environmental issue obtaining these compounds while reducing negative impact on surrounding environment remains relevant. This article describes for first time method γ-crotonolactone synthesis is based concept green...

Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and corresponding α-halocarbonyl compounds in good yields.A series of chemical transformations obtained products carried out, new thiazole derivatives with aliphatic, aromatic heterocyclic substituents synthesized.4-Phenyl-substituted N-(4-hydroxyphenyl)-N-carboxyalkylaminothiazoles used as precursors for synthesis bis(thiazol-5-yl)methane derivatives,...

Interaction of an order aminoanthraquinones with benzoylisothiocyanate resulting in the formation new N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthacen-1yl)-thioureas was investigated.Quantum-chemical calculations using Gaussian 03W and HyperChem 8 were carried out.On their basis nucleophilic addition to (charge control) confirmed.A probable mechanism suggested.Influence orthosubstituents on passing reaction explained.Values absolute hardness softness calculated.

The nitro group–substituted perhalogenobuta-1,3-diene (1) is important synthetic precursor in the synthesis of different heterocycles groups with high biological activity. Firstly, new N,S-substituted-perhalonitro-1,3-butadiene compounds were synthesized by reactions various amino or thiol containing nucleophiles 1. structures all have been identified using spectroscopic techniques (FT-IR, 1H-NMR, 13C-NMR, MS and microanalysis). Secondly, their antimicrobial properties tested as potential...

A series of target 4-substituted-5-(2-(pyridine-2-ylamino)ethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones and their chloro analogs 7–21 were synthesized in a reaction the selected aldehydes with corresponding 4-amino-1,2,4-triazole-3-thiones 5 6, which obtained from 3-(pyridin-2-ylamino)propanoic acid (3) or 3-((5-chloropyridin-2-yl)amino)propanoic (4), respectively, thioacetohydrazide. The antibacterial antifungal activities hydrazones screened against bacteria Escherichia coli,...

The global emergence and dissemination of multidrug-resistant fungal bacterial pathogens is a serious public health threat. development novel highly active antimicrobial compounds simultaneously targeting several targets in or could help to fight resistance. four-component one-pot two-step facile synthesis new 2-dithiocarbamate-N-(9,10-dioxo-9,10-dihydroanthracenyl)acetamides 3a-n by the interaction 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracenyl)acetamide 1 2 with series situ generated...

The reactions of 1,4(1,5)-diazido-9,10anthracenediones with phenylacetylene and methyl propiolate under copper(I)-catalyzed reaction the azidealkyne cycloaddition conditions have been studied a series new 1,2,3-triazole derivatives 9,10anthracendione obtained.The computer screening synthesized compounds was carried out using PASS Online software to identify areas experimental biomedical researches.Compounds high affinity receptors family tyrosine kinases epidermal growth factor EGFR found...

The synthesis of new N-(9,10-dioxo-9,10-dihydroanthracen-1(2)-yl)-2-(R-thio) acetamides was carried out using reaction 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracene-1(2)-yl)acetamides with functionalized thiols in the presence potassium carbonate N,N-dimethylformamide (DMF) at room temperature. Evaluation synthesized compounds on such indicators radical scavenging activity as lipid peroxidation (LP) and oxidative modification proteins (OMP) vitro rat liver homogenate out. It determined that...

Anthraquinones have attracted considerable interest in the realm of cancer treatment owing to their potent anticancer properties. This study evaluates potential a series new anthraquinone derivatives as agents for non-small-cell lung (NSCLC). The compounds were subjected range tests assess cytotoxic and apoptotic properties, ability inhibit colony formation, pro-DNA damage functions, capacity activity tyrosine kinase proteins (PTKs). Based on research findings, it has been discovered that...