A5087798983- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Free Radicals and Antioxidants
- Synthesis and Biological Evaluation
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Click Chemistry and Applications
- Bioactive Compounds and Antitumor Agents
- Synthesis and Catalytic Reactions
- Enzyme function and inhibition
- Fungal Plant Pathogen Control
- Quinazolinone synthesis and applications
- Chemical Reactions and Mechanisms
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Natural Compound Pharmacology Studies
- Plant tissue culture and regeneration
- Chemical synthesis and pharmacological studies
- Flowering Plant Growth and Cultivation
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Phytochemicals and Antioxidant Activities
- Polysaccharides and Plant Cell Walls
- Multicomponent Synthesis of Heterocycles
- Phytochemistry and Biological Activities
- Melanoma and MAPK Pathways
- Synthesis of Organic Compounds
Kaunas University of Technology
2015-2025
4-Phenyl-3-[2-(phenylamino)ethyl]-1H-1,2,4-triazole-5(4H)-thione was used as a starting compound for the synthesis of corresponding 1,2,4-triazol-3-ylthioacetohydrazide, which reacts with isatins and various aldehydes bearing aromatic heterocyclic moieties provided target hydrazones. Their cytotoxicity tested by MTT assay against human melanoma IGR39, triple-negative breast cancer (MDA-MB-231), pancreatic carcinoma (Panc-1) cell lines. The selectivity compounds towards cells also studied. In...
A series of novel mono and bishydrazones each bearing a 2-oxindole moiety along with substituted phenylaminopropanamide, pyrrolidin-2-one, benzimidazole, diphenylmethane, or diphenylamine fragments were synthesized, their anticancer activities tested by MTT assay against human melanoma A375 colon adenocarcinoma HT-29 cell lines. In general, the synthesized compounds more cytotoxic than A375....
It is well-known that thiazole derivatives are usually found in lead structures, which demonstrate a wide range of pharmacological effects. The aim this research was to explore the antiviral, antioxidant, and antibacterial activities novel, substituted compounds find potential agents could have biological one single biomolecule. A series novel aminothiazoles were synthesized, their activity characterized. obtained results compared with those standard anticancer agents. compound bearing...
A series of novel hydrazones bearing diphenylamine and 5-oxopyrrolidine moieties, along with benzene naphthalene rings substituted hydroxy, alkoxy, or carboxylic groups, were synthesized. Their anticancer activity was evaluated in vitro using both 2D (MTT ‘wound healing’ assays) 3D (cell spheroid) models against human melanoma IGR39 cells, the triple-negative breast cancer cell line MDA-MB-231, pancreatic carcinoma Panc-1 line. Compounds 8 (2-hydroxybenzylidene derivative) 12...
The title compounds were synthesized by the reaction of 5-oxo-1-(4-(phenylamino)phenyl)pyrrolidine-3-carbohydrazide with various aldehydes bearing aromatic and heterocyclic moieties acetophenones, their cytotoxicity was tested via MTT assay against human triple-negative breast cancer MDA-MB-231, melanoma IGR39, pancreatic carcinoma Panc-1, prostate cell line PPC-1. Furthermore, selectivity towards cells compared to fibroblasts also investigated. Four identified as most promising anticancer...
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, XIII was studied by the fluorescent thermal shift assay isothermal titration calorimetry. The results showed that 4-substituted more potent CA binders than derivatives. Most better affinity for II while possessed nanomolar affinities towards I isozyme. X-ray crystallographic structures modes both compound groups.
Series of novel 3-[(4-methoxyphenyl)amino]propanehydrazide derivatives bearing semicarbazide, thiosemicarbazide, thiadiazole, triazolone, triazolethione, thiophenyltriazole, furan, thiophene, naphthalene, pyrrole, isoindoline-1,3-dione, oxindole, etc. moieties were synthesized and their molecular structures confirmed by IR, 1H-, 13C-NMR spectroscopy mass spectrometry data. The antioxidant activity the compounds was screened DPPH radical scavenging method....
Series of 2-and 1,2-disubstituted benzimidazoles with carboxyalkyl substituents or their derivatives were synthesized during chemical transformations 4-(1H-benzimidazol-2-yl)-1-(3-chloro-4-methoxyphenyl)pyrrolidin-2-one.Condensation products 2-{2-[1-(3-chloro-4-metoxylphenyl)-5-oxo-3-pyrrolidinyl]-1H-benzimidazol-1-yl}acetohydrazide and 3-(1H-benzimidazol-2-yl)-4-(3-chloro-4-methoxyphenylamino)butanoic acid hydrazide monoand dicarbonylic compounds have been obtained.Some the are...
A series of target 4-substituted-5-(2-(pyridine-2-ylamino)ethyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones and their chloro analogs 7–21 were synthesized in a reaction the selected aldehydes with corresponding 4-amino-1,2,4-triazole-3-thiones 5 6, which obtained from 3-(pyridin-2-ylamino)propanoic acid (3) or 3-((5-chloropyridin-2-yl)amino)propanoic (4), respectively, thioacetohydrazide. The antibacterial antifungal activities hydrazones screened against bacteria Escherichia coli,...
Novel pyrrole and pyrazole derivatives containing phenylaminopropanoyl moiety were synthesized from 3-phenylaminopropanohydrazide through its condensation with diketones.The intramolecular cyclization reaction of disubstituted semicarbazides thiosemicarbazides was used to prepare new 1,3,4-thiadiazole, 1,3,4-oxadiazole 1,2,4-triazole compounds.Some the compounds evaluated for in vitro antimicrobial activity.* + -the compound exhibits activity (growth microbial strain is inhibited), ** --the...
A series of novel 1-(5-chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives containing chloro, hydroxyl, isopropyl, nitro, nitroso, and amino substituents at benzene ring 1-(5-chloro-2-hydroxyphenyl)-5-oxopyrrolidine-3-carbohydrazide bearing heterocyclic moieties were synthesized. Antioxidant activity the synthesized compounds was screened by DPPH radical scavenging method reducing power assay. number identified as potent antioxidants....
Natural extracts of Hypericum perforatum L. are widely used in the pharmaceutical industry due to their antiviral, antioxidant, antibacterial, antidiabetic, and antidepressant activities. Plant biotechnological methods gaining more attention as efficient biosustainable approaches for production high value compounds by using plant callus cultures vitro. The aim this research was evaluate influence phytohormones on formation culture, explore antioxidant antibacterial activities, determine...
A synthesis of 2-((4-phenyl-5-(2-(p-tolylamino)ethyl)-4H-1,2,4-triazol-3-yl)thio)-N’-(1-phenylethylidene)acetohydrazide from 2-[(3-{2-[(4-methylphenyl)amino]ethyl}-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-yl)sulfanyl]acetohydrazide and acetophenone is reported. The title compound has been tested to possess 1.5-fold higher antioxidant ability than the control, butylated hydroxytoluene, as determined by a Ferric reducing power assay.
A synthesis of N′-(1,3-dithiolan-2-ylidene)-3-(phenylamino)propanehydrazide from 3-(phenylamino)propanehydrazide, carbon disulfide and 1,2-dibromoethane is reported. The title compound was characterized by 1H NMR, 13C ESI/MS, elemental analysis.
Abstract A variety of novel S‐alkylated triazolethiones are synthesized and evaluated for their free radical scavenging activity.