Oral administration of water-soluble pristine C₆₀ fullerene in small dose prevents acute liver injury caused by carbon tetrachloride rats.

The disease COVID-19, caused by SARS-CoV-2 infection, has a systemic effect and is associated with number of pathophysiological mechanisms that mobilize wide range biomolecules. Cytokines growth factors (GFs) are critical regulators tissue damage or repair in osteoarthritis (OA) being recognized as key players the pathogenesis COVID-19. A clear understanding long-term consequences especially patients concomitant chronic diseases, limited needs to be elucidated. study aimed evaluate degree...

In this study, we present the potential application of deuterium-depleted water (DDW) for prevention and adjuvant treatment obesity in rats. We tested hypothesis that DDW can alleviate diet-induced (DIO) its associated metabolic impairments. Rats fed a high-fat diet had an increased body weight index (BWI), glucose concentration, level certain proinflammatory cytokines; decreased levels insulin serum; tryptophan serotonin brain, concentration some heavy metals liver. Drinking at 10 ppm...

Background and Objectives: Coronary artery disease (CAD) is the foremost cause of adult disability mortality. There an urgent need to focus on research new approaches for prevention treatment CAD. Materials Methods: The effects peptides isolated from blood plasma CAD patients endothelial cell secretion using in vitro model have been tested. Human progenitor cells (HEPCs) were incubated 24 h with healthy subjects or stable angina, progressive unstable myocardial infarction. contents some...

Nowadays, more than two billion inhabitants of underdeveloped tropical and subtropical countries are at risk being stung by scorpions. Scorpion stings annually cause 2000-3000 deaths as they can lead to the respiratory and/or cardiovascular complications. Pathogenesis lung damage under scorpion envenomation is often comprehensive. Respiratory failure have a cardiogenic origin, associated with venom neurotoxin action. However, some components stimulate pro-inflammatory signaling cascades...

Protein hydrolysates and plant peptide extracts can become next-generation natural, eco-friendly food supplementary with a wide range of bioactive features. From folk medicine, it is known about the aqueous extract common bean (Phaseolus vulgaris) its exceptional treatment Various abilities peptides from P.vulgaris have been closely studied in recent years, but another component “bean pod tea” – husk has not at all. Therefore, this study aimed to obtain perform primary analysis husks using...

Background. COVID-19 is associated with disorders in the blood coagulation system that may persist beyond acute phase of disease, particularly individuals pre-existing cerebrovascular conditions. This research purposed to evaluate changes key parameters procoagulant, anticoagulant, and fibrinolytic links hemostatic patients chronic cerebral ischemia (CCI) following recovery from COVID-19. Materials methods. The study involved 100 aged 43 74 years diagnosed CCI divided into two experimental...

Viper snakebite is considered to be a serious and life-threatening medical problem due its ability cause various types of coagulopathies. The current study aimed investigate the effects Vipera berus nikolskii venoms on hemostasis in rats. To determine possible mechanisms coagulopathy that occurred as post-bite complication, hemostatic parameters were studied experimental animals 24 hours after single intraperitoneal injection V. b. or venom. obtained results compared those control group,...

Graphene oxide (GO), owing to its extraordinary application prospects in biomedicine, is attracting growing research attention. However, the biosafety and blood compatibility of GO required for clearance use clinical trials remain elusive. Therefore, we studied mutagenic properties as well cell toxicity compatibility. Prior biological experiments, assessed structural organization using dynamic light scattering microscopic visualization methods. The results both Ames mutagenicity test...

Zinc is a critical micronutrient that plays multifaceted roles in oxidative stress management, lipid metabolism, pancreatic function, and liver health, which are all closely interconnected with obesity. Maintaining adequate zinc levels essential for overall metabolic health proper functioning of these vital systems. The investigational new drug complex zinc-64 aspartate (KLS-1 or 64 Zn-aspartate) was evaluated this study as pharmaceutical agent targeting metabolism using rodent model KLS-1...

Background. The purpose of this study was to determine the cytokine profile, levels proteolytic enzymes, and TIMP-1 in plasma patients with chronic cerebral ischemia (CCI) following symptomatic COVID-19, considering gender differences. Materials methods. research involved 108 CCI aged 43 74 years, including 56 who had been diagnosed COVID-19 past 9–12 months (CCI group) 52 no history SARS-CoV-2 infection group). participants were also stratified by gender. Plasma cytokines (IL-1, IL-4, IL-6,...

Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPS) play a key role in the pathogenesis of osteoarthritis (OA). Recent research showed involvement some MMPs COVID-19, but results are limited contradictory.In this study, we investigated levels (MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10) TIMP-1 plasma patients with OA after recovery from COVID- 19.The experiment involved aged 39 to 80 diagnosed knee OA. All study participants were divided into three groups: control group...

Suppressive effect of Ginkgo biloba extract (EGb 761) on topsin induced ovarian toxicity and oxidative stress in albino ratsSaber A. Sakr,Hoda Mahran, Asmaa M. Abdel-Maksoud

Aim.To identify the effect of probiotic (PB) on cytokines profile in knee cartilage rats with experimental osteoarthritis (OA).Methods.The animals 1 st (Сontrol) and 3 rd groups got 50 µL saline to both hind knees.The 2 nd (MIA-OA) 4 th (MIA-OA-PB) single injection mg monoiodoacetate (MIA) dissolved knee, after which MIA-OA developed for 28 days.PB feeding [was] provided daily 14 days during progress.The levels (IL-1β, TNF-α, IL-6, IL-8, IFN-γ, IL-4, IL-10, TGF-β, IGF-1) were measured...

Introduction This study aimed to develop an optimal method for the production of fish hydrolysates and test their effectiveness as plant biostimulants under low-temperature growing conditions. Methods To obtain hydrolysates, waste a rainbow trout was used. Hydrolysates were prepared by enzymatic hydrolysis using entrails source enzymes. Differences in methods obtaining hydrolysates: samples І, ІІ, ІІІ, IV placed into water bath at +37°C, sample V left room temperature. Further nitric,...

Thiosulfonate derivatives based on quinones were synthesized for studying "structure-activity relationship" compounds with an acylated and a free amino-group. Anti-platelet activity of the was determined influence substituents assessed.

Potent Inhibitors for Receptor Tyrosine KinasesThe influence of new derivatives 9,10-anthraquinone with benzoylthiourea, thiazole, triazole and amino acid fragments on the activity membrane-associated tyrosine kinases was investigated.Inhibitors protein kinase membrane fraction, as promising agents to search potential anticancer among studied compounds, were discovered.

// Tatiana Halenova 1 , Oleksii Savchuk Ludmila Ostapchenko Andrey Chursov 2 Nathan Fridlyand 3 B. Komissarov 4 Franco Venanzi Sergey I. Kolesnikov 5, 6, 7 Albert A. Sufianov 8, 9 Michael Y. Sherman 10 Vladimir L. Gabai 2, and Alexander M. Shneider 9, 11 Educational Scientific Center ‘Institute of Biology Medicine’, Taras Shevchenko National University Kyiv, Ukraine Curelab Oncology Inc, Dedham, MA, USA School Biosciences, Camerino, Italy Research Institute Influenza,...

According to the current understanding, hyperactivation of platelets may lead increased intravascular coagulation and thrombosis. Today a relevant issue is search for new anti-thrombotic agents that are able modulate activity platelet receptors, thus, influence processes activation aggregation platelets. The aim this study was investigate effects newly synthesized thiosulfonate derivatives on aggregation. compounds tested in vitro using platelet-rich plasma. As result screening test,...

The hemostasis system has been extensively investigated in patients the acute phase of coronavirus disease 2019 (COVID-19). In contrast, post-COVID syndrome is a poorly known entity, and there lack information on mechanisms underlying abnormalities period.To analyze potential changes parameters post- COVID period plasma donors with different titers anti-SARS-CoV-2 IgG.The from 160 who had recovered infection was used study. Based results Abbott SARS-CoV-2 IgG serological assay, all were...

The aim of the present study was to determine whether orally applied collagen fragments (CFs) could affect development obesity in obese rats. To this end, experimental rats that were exposed a high-calorie diet (HCD) for four weeks randomly divided into two groups: HCD and HCD+CFs, with both groups continuing receive HCD. However, from HCD+CFs group also provided CFs 0.05-M citrate buffer (pH 5.0) (1 g·kg-1 body weight) by intragastric administration, every other day next six weeks. Selected...