Osteoarthritis (OA) is a common worldwide disease induced by wide range of biochemical processes, mainly inflammation and degradation collagen. The aim this study, was to describe the effect multistrain probiotic (PB) chondroitin sulfate (CS), administered separately or in combination, on expression Ptgs2, Tgfb1 Col2a1 during monoiodoacetate-induced OA male rats.OA rats injecting monoiodoacetate right hind knee. Therapeutic groups received 3 mg/kg CS for 28 days and/or 1.4 g/kg PB 14 days....

Introduction Although the role of tumor immune microenvironment (TIME) in thyroid cancer is well established, little data exists about differences cell presence adenomas and carcinomas. We assume that density could be an additional diagnostic criterion for differentiating benign malignant tumors aspirates. Aim The current study compared contexture adenoma (TA) carcinoma (TC) histological cytological specimens III-V categories. Materials methods This pilot included 72 cases (36 TA 36 TC) with...

BACKGROUND: Osteoarthritis (OA) is a joint affection, defined by articular cartilage demolition, risks of which rise with age. The aim this study was to compare the efficacy chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on expression TLR-2, TLR-4, TNF-α NF-κB cartilage, subchondral bone synovial membrane during OA rats.METHODS: induced male rats injecting monoiodoacetate (MIA) right hind knee. Therapeutic groups received 3 mg/kg...

Osteoarthritis (OA) is a highly heterogeneous joint disease characterized by pain and progressive loss of articular cartilage. The therapeutic potential using probiotics to treat OA has only recently been recognized, with small number animal human studies having undertaken. Transfigurations gut microbiota, as well the favorable results associated it, can be reached maintaining healthy lifestyle, including physical exercises, diet enriched vitamins, minerals, prebiotics probiotics, regular...

Aim.To identify the effect of probiotic (PB) on cytokines profile in knee cartilage rats with experimental osteoarthritis (OA).Methods.The animals 1 st (Сontrol) and 3 rd groups got 50 µL saline to both hind knees.The 2 nd (MIA-OA) 4 th (MIA-OA-PB) single injection mg monoiodoacetate (MIA) dissolved knee, after which MIA-OA developed for 28 days.PB feeding [was] provided daily 14 days during progress.The levels (IL-1β, TNF-α, IL-6, IL-8, IFN-γ, IL-4, IL-10, TGF-β, IGF-1) were measured...

Osteoarthritis (OA) is a widespread pathology of the musculoskeletal system.OA may associate with wide range disorders, that lead to development various strategies on how prevent and treat disease.recent studies discussed interactions between microbiome pathologies, including OA.In this study, we investigated effect probiotic cultures oxidative/antioxidant balance in blood rats during OA.Experimental OA was induced by single injection sodium monoiodoacetate into knee joint.A composition...

Osteoarthritis is a most widespread chronic degenerative joint disease that causes pain, cartilage deformation, and inflammation. Adverse alterations of intestinal microbiota like dysbiosis may lead to metabolic syndrome inflammation, two important components osteoarthritis progression. Aim. In this study we investigated the effect chondroitin sulfate probiotics on gut microbiome in monoiodoacetate-induced model rats. Methods. The species quantitative composition feces were determined using...

Blood cytokines affect the development of inflammatory processes in both normal and pathological states. We have studied changes concentration interleukins (ILs) - 1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis (TNF-α) acute carrageenan-induced inflammation degenerative-dystrophic knee joint caused by monoiodoacetate-induced Osteoarthritis (OA) experimental models on rats. also investigated change cytokine profile during prophylactic therapeutic...

Rheumatoid Arthritis (RA) is an autoimmune polygenic disease characterized by rapid disability progression and high prevalence. Progression of RA closely associated with chronobiological changes in the production some hormones inflammatory mediators, influencing course therapy efficacy. The main pathogenetic mechanism angiogenesis, which controlled biological clock-genes. Further investigation circadian rhythms angiogenic mediators patients may be considered as important relevant. aim this...

The relationship between vitamin D deficiency and the metabolic syndrome has recently been revealed. Vitamin was hypothesized to cause increased insulin resistance decreased secretion, which can result in development of diabetes mellitus obesity. Cardiovascular diseases are also closely related syndrome. shown have complex multistep metabolism act as a hormone at many extraskeletal targets. In this literature review, comprehensive analysis publications from Scopus, Web Science, MedLine,...

Biochemical indices of blood and tissue the gastrocnemius muscle chronically alcoholized (for 3, 6 9 months) rats were studied. С60 fullerene aqueous solution (C60FAS) was administered orally as a pharmacological agent at dose 1 mg/kg daily throughout experiment in three routes: h before alcohol intake (preventive regimen), together with (therapeutic regimen I) after II). Creatine phosphokinase (CPK), lactate dehydrogenase (LDH), catalase, superoxide dismutase, glutathione peroxidase (GPx)...

The C60 fullerene effect (oral administration at a dose of 1 mg kg-1) on the selected biomechanical parameters muscle gastrocnemius contraction, biochemical indicators blood and tissue as well histological changes in rat after chronic alcoholization for 3, 6 9 months was studied detail. Water-soluble fullerenes were shown to reduce pathological processes development apparatus by an average (35-40)%. In particular, they reduced time occurrence fatigue during long-term alcoholic myopathy...

Introduction According to WHO, antibiotic resistance is increasing hazardous levels worldwide. Candidiasis often occurs after taking antibiotics. Therefore, a global problem and searching for antibacterial agents necessary. Aim To determine the antimicrobial activity of bacterial lysate Lactobacillus (L.) rhamnosus DV separately with plant extracts against yeast test cultures. Material methods Antimicrobial Del-Immune V ® (cell wall DNA fragments from L. DV) cinnamon, beetroot, blackcurrant...

The 2019 coronavirus disease (Coronavirus 2019, COVID-19) poses a great threat to the health of people in all countries world. Infection with SARS-CoV-2 (Severe acute respiratory syndrome-related 2) is characterized by development severe life-threatening complications. COVID-19 more likely be and sometimes fatal, especially older co-morbidities. A topical issue predicting course chronic diseases who have contracted infection. An increasing number cases arthritis associated been reported...

BACKGROUND: Osteoarthritis (OA) is one of the most common pathologies musculoskeletal system. Recent studies have shown involvement oxidative stress in both pathogenesis OA and effects therapeutic agents used for its treatment. The aim this study was to investigate combined effect chondroitin sulfate multiprobiotic on oxidative-antioxidant blood system rats under conditions OA.METHODS: Experimental induced male by injection sodium monoiodoacetate (MIA; Sigma-Aldrich, Munich, Germany) into...

Disorders in the blood coagulation system play an important role pathogenesis and clinical manifestations of COVID-19 both during acute phase disease post-infectious period. The coronavirus is associated with a high risk thrombotic thromboembolic complications due to prolonged state hypercoagulation, which can occur even after recovery. Despite extremely large amount scientific data, pathophysiological aspects SARS-CoV-2 infection remain uncertain. presented review summarizes results modern...