A5049399142- Cassava research and cyanide
- Child Nutrition and Water Access
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Neurological diseases and metabolism
- Heavy Metal Exposure and Toxicity
- African Botany and Ecology Studies
- Health, Environment, Cognitive Aging
- Pesticide Exposure and Toxicity
- Parkinson's Disease Mechanisms and Treatments
- Iron Metabolism and Disorders
- HIV/AIDS Research and Interventions
- Global Maternal and Child Health
- Disaster Response and Management
- Viral Infections and Vectors
- Water resources management and optimization
- Trypanosoma species research and implications
- Food Security and Health in Diverse Populations
- Heavy metals in environment
- Amyotrophic Lateral Sclerosis Research
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Alzheimer's disease research and treatments
- HIV Research and Treatment
- Folate and B Vitamins Research
University of Kinshasa
2014-2025
Oregon Health & Science University
2016-2025
National Institute of Biomedical Research
2014-2025
University of Lubumbashi
2021
Ministry of Public Health
2013-2016
Michigan State University
2013
Clinique Saint-Joseph
2013
University of North Carolina at Chapel Hill
2013
University of Bergen
2013
University of Portland
2009-2013
BACKGROUND: Konzo is an irreversible upper-motor neuron disorder affecting children dependent on bitter cassava for food. Although the neuroepidemiology of konzo well characterized, we report first neuropsychological findings. METHOD: Children with in Democratic Republic Congo (mean age 8.7 years) were compared without 9.1 Kaufman Assessment Battery Children, second edition (KABC-II), and Bruininks-Oseretsky Test Motor Proficiency, (BOT-2). Both groups also normative KABC measures from...
Abstract Water security requires not only sufficient availability of and access to safe acceptable quality for domestic uses, but also fair distribution within across populations. However, a key research gap remains in understanding water inequality its dynamics, which turn creates an impediment tracking progress towards sustainable development. Therefore, we analyse the using data from 7603 households 28 sites 22 low- middle-income countries, measured Household Insecurity Experiences Scale....
Methanolic and dichloromethane extracts from the leaves of Congolese Hibiscus species were characterised by chromatographic spectroscopic techniques their in vitro biochemical activities against ROS production evaluated cellular models on an enzyme, myeloperoxidase (MPO), involved inflammation. acetosella has a chemical fingerprint different cannabinus sabdariffa both having similar fingerprints. Major compounds polyphenols, represented mainly caffeoyl-hydroxycitric acid for H....
Background Dietary cyanogen exposure from ingesting bitter (toxic) cassava as a main source of food in sub-Saharan Africa is related to neurological impairments Africa. We explored possible association with early child neurodevelopmental outcomes. Methods undertook cross-sectional assessment 12–48 month-old children using the Mullen Scale Early Learning (MSEL) and Gensini Gavito (GGS). used Hopkins Symptoms Checklist-10 (HSCL-10) Goldberg Depression Anxiety (GDAS) screen for symptoms...
Abstract Household survey data from 27 sites in 22 countries were collected 2017–2018 order to construct and validate a cross-cultural household-level water insecurity scale. The resultant Water Insecurity Experiences (HWISE) scale presents useful tool for monitoring evaluating interventions as complement traditional metrics used by the development community. It can also help track progress toward achievement of Sustainable Development Goal 6 ‘clean sanitation all’. We present HWISE scores...
Motor neuron axonopathy in diseases such as amyotrophic lateral sclerosis can be modeled and probed with neurotoxic chemicals that induce similar patterns of pathology, axonal spheroids represent focal accumulation anterogradely transported neurofilaments (NFs). The aromatic γ-diketone–like 1,2-diacetylbenzene (1,2-DAB), but not its 1,3-DAB isomer, reacts ϵ-amino- or sulfyhydryl groups (neuro)proteins, forms adducts, causes NFs to accumulate at proximal sites elongate motor axons. We exploit...
Neuroprotein changes in the spinal cord of rodents with aliphatic γ-diketone axonopathy induced by 2,5-hexanedione (2,5-HD) are compared those reported previously aromatic γ-diketone–like 1,2-diacetylbenzene (1,2-DAB). Sprague-Dawley rats were treated intraperitoneally 500 mg/kg/day 2,5-HD, equimolar doses 2,3-hexanedione (negative control), or an equivalent amount saline containing 50% dimethyl sulfoxide (vehicle), 5 days a week, for 3 weeks. Analysis lumbosacral proteome 2-dimensional...
We sought to elucidate the protein carbamoylation patterns associated with cyanate neuropathy relative cyanide poisoning. hypothesized that under a diet deficient in sulfur amino acids (SAA), pattern poisoning is similar of neuropathy. Male rats (6-8 weeks old) were fed all (AAA) or 75%-deficiency SAA and treated 2.5 mg/kg/body weight (bw) NaCN, 50 mg/kg/bw NaOCN, 1 μl/g/bw saline, for up 6 weeks. Albumin spinal cord proteins analyzed using liquid chromatography mass spectrometry (LC-MS/MS)....
Konzo is an irreversible upper-motor neuron disorder affecting children dependent on bitter cassava for food. The neurocognitive ability of with konzo over time has yet to be fully documented.We did a longitudinal study in outbreak zone continuously affected by since 1990, the district Kahemba, southern Bandundu Province, Congo. We enrolled record neurological diagnosis Kahemba town. For all final sample baseline assessment, exam was done neurologists confirm using 1996 WHO criteria at 2...
Abstract To elucidate the involvement of motor pathways in konzo, 21 konzo subjects (mean age 22 years) underwent transcranial electrical stimulation (TES) 1998. Fourteen magnetic (TMS) 2000. Three both TES and TMS. Motor evoked potentials (MEPs) were recorded abductor pollicis brevis (APB) muscle with TES, digiti minimi (ADM) tibialis anterior (TA) muscles APB‐MEPs normal 2 absent 9; central conduction time (CCT) was prolonged 10. Resting ADM‐MEPs 9 14 clinically preserved upper limbs....