A5088699403- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Nitric Oxide and Endothelin Effects
- Cardiovascular Effects of Exercise
- COVID-19 Clinical Research Studies
- Transplantation: Methods and Outcomes
- Electrostatic Discharge in Electronics
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Ion Transport and Channel Regulation
- Diet, Metabolism, and Disease
- Cyclone Separators and Fluid Dynamics
- Sulfur Compounds in Biology
- Spinal Cord Injury Research
- Cardiovascular and Diving-Related Complications
- Advanced Sensor Technologies Research
- Mercury impact and mitigation studies
- Migraine and Headache Studies
- Phonocardiography and Auscultation Techniques
- Advanced Power Generation Technologies
- Air Quality and Health Impacts
Cedars-Sinai Smidt Heart Institute
2016-2025
Cedars-Sinai Medical Center
2016-2025
Sinai Health System
2020-2024
Jacobs Institute
2018
Madras Medical Mission
2017
Indiana University – Purdue University Indianapolis
2017
University of Pennsylvania
2017
Icahn School of Medicine at Mount Sinai
2017
Stanford University
2017
University of California, San Francisco
2017
We tested whether consumption of a high-fat, high-sucrose (HFS) diet can affect endothelium-dependent relaxation, this precedes the development diet-induced hypertension previously noted in model, and it is mediated, part, by changes nitric oxide synthase (NOS) and/or NOS regulatory proteins. Female Fischer rats were fed either HFS or standard low-fat, complex-carbohydrate chow starting at 2 mo age for 7 mo. Vasoconstrictive response to KCl phenylephrine was similar both groups....
BACKGROUND: Catheter ablation of ventricular arrhythmias, one the most rapidly growing procedures in cardiac electrophysiology, is associated with magnetic resonance imaging–detected brain lesions more than half cases. Although a retrograde aortic approach conventional, modern tools enable entry through transseptal that may avoid embolization debris from arterial system. We sought to test hypothesis puncture would mitigate injury compared approach. METHODS: The TRAVERSE trial (Transseptal...
Earlier studies have shown increased production of reactive oxygen species (ROS) and upregulation ROS-generating enzyme, nicotinamide adenine dinucleotide (phosphate) oxidase, in the kidney spontaneously hypertensive rats (SHR). This study aimed to examine activities protein abundance main antioxidant enzymes [i.e. superoxide dismutase (SOD), catalase (CAT) glutathione peroxidase (GPX)] SHR fed a regular or an antioxidant-rich diet.Pregnant their offspring were either diet (alpha-tocopherol,...
Arrhythmias have been reported frequently in COVID-19 patients, but the incidence and nature not well characterized. Patients admitted with monitored by telemetry were prospectively enrolled study. Baseline characteristics, hospital course, treatment complications collected from patients' medical records. Telemetry was to detect of cardiac arrhythmias. The types arrhythmias analyzed compared between survivors non-survivors. Among 143 patients monitoring, overall in-hospital mortality 25.2%...
Abstract Aims Cardiomyopathy patients are prone to ventricular arrhythmias (VA) and sudden cardiac death. Current therapies prevent VA include radiofrequency ablation destroy slowly conducting pathways of viable myocardium which support re-entry. Here, we tested the reverse concept, namely that boosting local tissue viability in zones slow conduction might eliminate suppress ischaemic cardiomyopathy. Methods results Exosomes extracellular vesicles laden with bioactive cargo. secreted by...
Background— The underlying mechanisms of reentry during left posterior fascicular ventricular tachycardia (LPF-VT) remain unclear. purpose this study is to describe the components LPF-VT circuit and their electrophysiological properties. Methods Results— Fourteen consecutive patients with underwent electrophysiology radiofrequency ablation. Via a multipolar electrode catheter placed from retrograde aortic approach, sharp inflection, high-frequency potential (P1) was detected in 9 (64%)....
Abstract Aims Ablation of monomorphic ventricular tachycardia (MMVT) has been shown to reduce shock frequency and improve survival. We aimed compare cause-specific risk factors for MMVT polymorphic (PVT)/ventricular fibrillation (VF) develop predictive models. Methods results The multicentre retrospective cohort study included 2668 patients (age 63.1 ± 13.0 years; 23% female; 78% white; 43% non-ischaemic cardiomyopathy; left ejection fraction 28.2 11.1%). Cox models were adjusted demographic...
Multipolar mapping, a novel method of electrogram acquisition and annotation distinct from unipolar bipolar acquisitions, provides orientation-independent near-field signal with enhanced spatial precision. mapping use in humans has not been described. This study aimed to present findings on the multipolar variety different arrhythmia types mechanisms. We performed consecutive ablation procedures using high-density multipolar-capable catheter (OPTRELL, Biosense Webster, Irvine, CA). Parallel...
ABSTRACT Background Various methods have been used to identify substrate of persistent atrial fibrillation (PeAF) including complex fractionated electrograms (CFAEs), electrogram dispersion, and low‐voltage areas (LVAs). This study aims investigate their relationship changes following ablation. Methods Results Consecutive patients with PeAF undergoing catheter ablation were prospectively recruited. High‐density left mapping was employed. Repeat performed after pulmonary vein posterior wall...
The present investigation was carried out to study the expression of major cytochrome P450 (CYP) isozymes in streptozotocin-induced diabetes with concomitant insulin therapy. Male Sprague-Dawley rats were randomly assigned untreated control, diabetic, insulin-treated groups and monitored for 4 weeks. Uncontrolled hyperglycemia early phase resulted differential regulation isozymes. CYP1B1, CYP1A2, heme oxygenase (HO)-2 proteins CYP1A2-dependent 7-ethoxyresorufin O-deethylase (EROD) activity...
Sudden death is the most common mode of mortality in patients with heart failure and preserved ejection fraction (HFpEF). Ventricular arrhythmias (VA) have been suspected as etiology but supporting evidence HFpEF scarce. We sought to investigate VA prevalence, determine if are associated prolonged repolarization, HFpEF. In a retrospective case-control study design, Cedars-Sinai who underwent ambulatory electrocardiographic monitoring (Zio Patch) between 2016 2018 were screened for clinical...