A5007568831- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Teaching and Learning Programming
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Immune cells in cancer
- Morinda citrifolia extract uses
- Neurological Disease Mechanisms and Treatments
- Medicinal Plants and Bioactive Compounds
- Connexins and lens biology
- Evolutionary Algorithms and Applications
- Online Learning and Analytics
- Embedded Systems Design Techniques
- Biochemical Analysis and Sensing Techniques
- Innovative Teaching and Learning Methods
- Chemokine receptors and signaling
- Autism Spectrum Disorder Research
- Phytochemicals and Antioxidant Activities
- Educational Research and Pedagogy
- Eicosanoids and Hypertension Pharmacology
- Education and Learning Interventions
- Drug Transport and Resistance Mechanisms
- Alcohol Consumption and Health Effects
- Computational Drug Discovery Methods
- Drug Solubulity and Delivery Systems
University of Coimbra
2008-2022
Centro de Neurociências e Biologia Celular
2020-2021
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
2017-2020
Instituto de Biologia Molecular e Celular
2017-2020
Universidade do Porto
2018
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation small GTPase Rhoa adult is sufficient to trigger spontaneous activation, producing a neurological phenotype (including synapse and neuron loss, impairment long-term potentiation [LTP], formation β-amyloid plaques, memory deficits). Mechanistically, loss triggers Src activation Src-mediated tumor necrosis factor (TNF) production, leading...
Alcohol abuse adversely affects the lives of millions people worldwide. Deficits in synaptic transmission and microglial function are commonly found human alcohol abusers animal models intoxication. Here, we that a protocol simulating chronic binge drinking male mice resulted aberrant pruning substantial loss excitatory synapses prefrontal cortex, which increased anxiety-like behavior. Mechanistically, intake engulfment capacity microglia manner dependent on kinase Src, subsequent activation...
Autism Spectrum Disorders (ASDs) are a group of neurodevelopmental pathologies whose current treatment is neither curative nor effective. Anthocyanins naturally occurring compounds abundant in blueberries and other red fruits which have been shown to be successful the several neurological diseases, at least vitro vivo disease models. The aim present work was study ability an anthocyanin-rich extract (ARE) obtained from Portuguese alleviate autism-like symptoms valproic acid (VPA) mouse model...
São várias as razões que tornam a aprendizagem de programação um processo difícil, ao qual abordagens ensino tradicionais não têm conseguido responder eficazmente. Muitas soluções tecnológicas sido desenvolvidas, porém o problema subsiste. Para além diversas apontadas por muitos autores como estando na origem deste problema, destacamos elevada dificuldade apresentada pelos alunos para resolver problemas genéricos. Esta é acentuada quando os são mais orientados à programação, traduzindo-se...
Dietary polyphenols are multi-target compounds that have been considered promising candidates in strategies for the mitigation of neurological diseases, acting particularly through reduction microglia-driven neuroinflammation. In this study, an anthocyanin-rich extract obtained from Portuguese blueberries was subjected to a simulated gastrointestinal digestion; after chemical characterisation, potential both non-digested and digested extracts combat neuroinflammation evaluated using...
Learning how to develop a program is known be difficult task many novice students. This problem which, neither the traditional teaching methods nor more sophisticated based on computational tools already proposed have been able meet.
The aim of this study was to develop multiparticulate systems with a combination ezetimibe micellar and atorvastatin solid dispersions using croscarmellose as hydrophilic vehicle Kolliphor RH40 surfactant. presence surfactant low polymer ratios produces the rapid dissolution through drug–polymer interaction that reduces its crystallinity. dispersion proportions showed interactions sufficient produce fast atorvastatin. Efficacy studies were performed in diabetic Goto-Kakizaki rats induced...
Abstract Nervous tissue homeostasis requires regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation the small GTPase Rhoa adult is sufficient to trigger spontaneous activation producing a neurological phenotype (including synapse and neuron loss, impairment LTP, formation ß-amyloid plaques memory deficits). Mechanistically, loss triggers Src Src-mediated Tnf production, leading excitotoxic glutamate secretion. Inhibiting...
Abstract Alcohol use adversely impacts the life of millions people worldwide. Deficits in synaptic transmission and microglial function are common findings human alcohol users animal models intoxication. Here, we show that intake over ten consecutive days resulted substantial loss excitatory synapse prefrontal cortex, a consequence aberrant pruning, which led to increased anxiety-like behavior. Mechanistically, these effects were mediated by detrimental increase microglia engulfment capacity...