A5074554260- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Ophthalmology and Eye Disorders
- Retinal Imaging and Analysis
- Cerebral Venous Sinus Thrombosis
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ocular Surface and Contact Lens
- Pregnancy and preeclampsia studies
- Neurological Complications and Syndromes
- Intraocular Surgery and Lenses
- Cerebrovascular and Carotid Artery Diseases
- Protein Kinase Regulation and GTPase Signaling
- Ocular Infections and Treatments
- Gestational Diabetes Research and Management
- Renal and Vascular Pathologies
- Cerebrovascular and genetic disorders
- Moyamoya disease diagnosis and treatment
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
- Retinopathy of Prematurity Studies
- Peroxisome Proliferator-Activated Receptors
- Retinal Development and Disorders
Helsinki University Hospital
2016-2025
University of Helsinki
2007-2025
Glaucoma Research Foundation
2019
Santen (Finland)
2018
Mary och Georg C. Ehrnrooths Stiftelse
2018
Kainuun keskussairaala
2015
Marymount University
2011
Karolinska Institutet
2004
Väestöliitto
2004
Turku University Hospital
2004
This article is an English translation of the 4th Finnish Current Care Guideline for diagnostics, treatment and follow‐up primary open‐angle glaucoma, normal‐tension glaucoma pseudoexfoliative glaucoma. guideline based on systematic literature reviews expert opinions with Finland's geographical operational healthcare environment in mind.
To study extracellular matrix (ECM) metabolism by metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in aqueous humor (AH) samples collected from primary open-angle glaucoma (POAG), exfoliation syndrome (EXS), (EXG) relation to derived cataract control patients.Seventy-one AH were during extraction trabeculectomy. The expression molecular forms of MMP-2, -8, -9, -13, -14 inhibitor metalloproteinases-1 -2 analyzed Western immunoblotting. Gelatinase collagenase activities studied...
Aims/Purpose: Selective laser trabeculoplasty (SLT) is a safe, effective, and common treatment for glaucoma ocular hypertension. There are reports of rare complications SLT, but the incidence these events not known. Here, we evaluated serious anterior segment after SLT. Methods: Eligible to study were patients who underwent SLT at Department Ophthalmology, Helsinki University Hospital from 1st January 2004 30th April 2018. From electronic medical records, demographics, procedure details,...
To evaluate the response of retinal capillary circulation to pregnancy in women with diabetes and correlate microcirculatory changes progression retinopathy during pregnancy.A prospective follow-up study 32 pregnant insulin-dependent 11 nondiabetic women. Perimacular blood flow measured noninvasively by flowmetry inferior perimacular retina. Eleven nonpregnant diabetic served as control subjects.In women, flows, small-box analysis, were 233 +/- 69 (mean SD) arbitrary units (AU) first...
<h3>Aim:</h3> To study whether reversal of optic disc cupping after intraocular pressure (IOP) reduction is related to risk glaucoma progression. <h3>Methods:</h3> In this prospective follow-up study, where 51 patients with exfoliation and five ocular hypertension combined syndrome were followed for 6 years IOP reduction, 24 showed progression in visual fields or nerve head (ONH) stereophotographs. ONH topography was measured the Heidelberg Retina Tomograph (HRT). A decrease HRT parameter...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a progressive systemic nonatherosclerotic angiopathy which causes ischemic strokes vascular dementia. A cross-sectional study was performed to examine the retinal caliber blood flow in CADASIL.Scanning laser Doppler flowmetry used case-control (11 patients controls) of peripapillary circulation. Automated full-field perfusion image analysis analyze data. Retinal vessel calibers were...
* BACKGROUND AND OBJECTIVE: To analyze changes in the optic disc topography after filtration surgery. PATIENTS METHODS. Laser scanning tomography was performed 10 eyes of 9 patients (mean age 65-6 ± 8.1 years; range 55 to 75 years) a mean follow-up 3.7 months, and 8 7 63.1 7.6 13.1 months. RESULTS: Preoperatively, intraocular pressure (IOP) 24.4 6.9 mm Hg with maximal medication. Postoperatively at months it 11.0± 2.2 Hg, 12.1 13.6 ±2.8 Hg. An initial reduction IOP more than 30% achieved...
Abstract Purpose To study the long‐term outcome of deep sclerectomy with and without mitomycin‐C ( MMC ) in patients normal‐tension glaucoma NTG ). Methods We prospectively analysed consecutive randomized to surgery performed either group) or (non‐ . Surgery was considered totally successful if, after surgery, preoperative intra‐ocular pressure IOP level reduced by 25% medication, a qualified success if medication required achieve same limits. Results A total 37 were enrolled, 15 22 non‐...
Purpose To study the effect of deep sclerectomy (DS) in primary open-angle glaucoma (POAG) and exfoliative (EXG). Methods We retrospectively analyzed intraocular pressure (IOP)-lowering DS 235 consecutive eyes. Eyes were divided into 2 groups according to subtype: POAG (127 eyes) EXG (108 eyes). Postoperative IOP was main outcome measurement. recorded complete qualified surgical success, need for YAG-laser goniopuncture, postoperative medication. studied factors related surgery a Cox...
To study the intraocular pressure (IOP)-reducing effect of deep sclerectomy on normal-tension glaucoma (NTG) patients.We retrospectively analysed 21 eyes 18 consecutive NTG patients who had undergone with mitomycin-C and a collagen implant.Median (range) preoperative IOP was 15.1 mmHg (9.3-20.8) median follow-up time 13 months (12-18). At 1-year visit, significantly (P < 0.001) reduced to 10.5 (4-15) reduction from values 37% (12-78). Laser goniopuncture performed in 10 (48%) 1-16...
Abstract Purpose To compare the outcome of deep sclerectomy ( DS ) with and without mitomycin‐C MMC in patients normal‐tension glaucoma NTG ). Methods We prospectively analysed results 37 eyes consecutive (age; mean ± SD ; 64 7 years) who underwent a collagen implant. Patients were randomized to non‐ groups. Subconjunctival (0.4 mg/ml for 3 min) was used intraoperatively 15 eyes. defined total success as 25% reduction intraocular pressure IOP medication. Follow‐up time 12 months. Results The...
PRéCIS:: The preoperative factors associated with a decreased survival rate of ab interno trabeculotomy (AbIT) perfomed using Trabectome in open-angle glaucoma were selective laser trabeculoplasty (SLT) performed previously and axial length (AL) over 23.82 mm.The purpose this study was to find that predict outcomes AbIT by Trabectome.This retrospective single-center cohort involved consecutive patients primary exfoliation treated at Helsinki University Hospital intraocular pressure (IOP) ≥18...
Abstract Purpose To study retinal blood flow and vessel diameter after intra‐ocular pressure ( IOP ) reduction in high‐ low‐pressure glaucomas, that is, exfoliation glaucoma (ExG) normal‐tension NTG ). Methods The included 17 eyes with ExG 20 . A minimum of 25% was achieved by deep sclerectomy. Blood the temporal peripapillary retina measured scanning laser Doppler flowmetry (Heidelberg Retina Flowmeter, HRF ), diameters were evaluated analyser RVA Examinations carried out before 3 months...
A bstract Purpose: The aim of this article is to study peripapillary retinal blood flow in patients with progressive and stable exfoliation glaucoma (ExG). Methods: Fifty‐eight eyes ExG were included; 25 them had 33 glaucoma. Retinal the retina was measured scanning laser Doppler flowmetry. Acquired maps analysed automatic full‐field perfusion image analyser. Multiple logistic regression used model progression Results: Mean (MF; correlation coefficient, P ‐value; R = 0.36, 0.006) minimum...
Purpose: To quantitate the effect of intravenous hypertonic saline (IVHTS) injection on elevated intraocular pressure (IOP). Methods: Nineteen patients (median age, 65 years; range, 41–84 years) with glaucoma and an IOP 30 mmHg or higher were recruited. A bolus IVHTS (sodium chloride concentration 23.4%) was injected in antecubital vein over 10–20 seconds. The systolic diastolic blood (BP) measured frequently for 2 hr. dosage 0.5 mmol/kg sodium 11 (Group 1) 1.0 eight 2). Results: In both...
To identify germline variants in myocilin (MYOC) and other known monogenic glaucoma genes Finnish patients with juvenile open-angle (JOAG).Finnish JOAG treated between 2010 2018 at the Department of Ophthalmology, Helsinki University Hospital, Finland, were enrolled. We sequenced all exonic regions flanking splice sites MYOC for five one healthy relative using Sanger sequencing. In 48 patients, we performed exome sequencing to also 28 glaucoma-related genes.Fifty-three individuals from 50...
Apolipoprotein E4 (APOE4), a known risk factor for Alzheimer's disease, has controversially been associated with reduced of primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we sought to systematically quantify the associations APOE haplotypes ocular diseases assess their scope age-dependency.We included genetic registry data from 412,171 Finnish individuals in FinnGen study. Disease endpoints were defined using nationwide registries. genotypes directly...