A5103116373- Nonlinear Dynamics and Pattern Formation
- Gene Regulatory Network Analysis
- Cancer Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Studies on Chitinases and Chitosanases
- stochastic dynamics and bifurcation
- Invertebrate Immune Response Mechanisms
- Nanoplatforms for cancer theranostics
- Immune cells in cancer
- Amino Acid Enzymes and Metabolism
- RNA and protein synthesis mechanisms
- Adsorption, diffusion, and thermodynamic properties of materials
- Neural dynamics and brain function
- CRISPR and Genetic Engineering
- Extracellular vesicles in disease
- Fungal and yeast genetics research
- Advanced Materials and Mechanics
- Chemical Thermodynamics and Molecular Structure
- Nanopore and Nanochannel Transport Studies
- Microfluidic and Bio-sensing Technologies
- Synthesis and Biological Evaluation
- Diffusion and Search Dynamics
- Cancer Immunotherapy and Biomarkers
- Trypanosoma species research and implications
- Aerogels and thermal insulation
Lublin University of Technology
2022
OncoArendi Therapeutics (Poland)
2017-2020
University of California, San Diego
2015-2016
Center for Systems Biology
2015-2016
University of Łódź
2015
McGill University
2011-2013
Tumor-driven immune suppression is a major barrier to successful immunotherapy in ovarian carcinomas (OvCa). Among various mechanisms responsible for suppression, arginase-1 (ARG1)-carrying small extracellular vesicles (EVs) emerge as important contributors tumor growth and escape from the host system. Here, we report that EVs found ascites plasma of OvCa patients contain ARG1. suppress proliferation CD4+ CD8+ T-cells vitro vivo mouse models. In mice, ARG1-containing are transported draining...
The progress in development of synthetic gene circuits has been hindered by the limited repertoire available transcription factors. Recently, it greatly expanded using CRISPR/Cas9 system. However, this system is its imperfect DNA sequence specificity, leading to potential crosstalk with host genome or circuit components. Furthermore, CRISPR/Cas9-mediated regulation context dependent, affecting modularity Cas9-based In paper we address problems specificity and developing a computational...
Arginases play essential roles in metabolic pathways, determining the fitness of both immune and tumour cells. Along with previously validated role ARG1 cancer, particular significance ARG2 as a therapeutic target has emerged its levels correlate malignant phenotype poor prognosis. These observations unveil arginases, specifically ARG2, well-validated promising targets. OATD-02, new boronic acid derivative, is only dual inhibitor, which can address benefits pharmacological inhibition...
Abstract Graphene oxide (GO) forms a well-aligned lyotropic liquid crystal (LC) phase in aqueous dispersions at relatively low concentrations. Under remarkably wide range of shear rates, we report hitherto unobserved shear-induced polarized light image patterns, Maltese cross combined with banding, recorded real time and situ during rheological measurements. This is shown to be result elastic flow instabilities that manifest as helical alternating bands left- right-handed helices, arising...
Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase) are the enzymatically active chitinases that have been implicated in pathology of chronic lung diseases such as asthma interstitial (ILDs), including idiopathic pulmonary fibrosis (IPF) sarcoidosis. The clinical preclinical data suggest pharmacological inhibition CHIT1 might represent a novel therapeutic approach IPF. Structural modification an advanced lead molecule 3 led to identification compound 9 (OATD-01), highly inhibitor...
The main aim of the present study was preparation and comprehensive characterization innovative additives to abrasive materials based on functional, pro-ecological lignin-alumina hybrid fillers. behavior lignin, alumina lignin-Al₂O₃ hybrids in a resin matrix explained basis their surface application properties determined by inverse gas chromatography, degree adhesion/cohesion between components, thermomechanical rheological properties. On presented results, hypothetical mechanism...
Acidic mammalian chitinase (AMCase) and chitotriosidase-1 (CHIT1) are two enzymatically active proteins produced by mammals capable of cleaving the glycosidic bond in chitin. Based on clinical findings animal model studies, involvement chitinases has been suggested several respiratory system diseases including asthma, COPD, idiopathic pulmonary fibrosis. Exploration structure–activity relationships within series 1-(3-amino-1H-1,2,4-triazol-5-yl)-piperidin-4-amines, which was earlier...
The Turing instability was proposed more than six decades ago as a mechanism leading to spatial patterning, but it has yet be exploited in synthetic biology setting. Here we characterize the specific gene circuit that can implemented vitro or populations of clonal cells producing short-range activator N-Acyl homoserine lactone (AHL) and long-range inhibitor hydrogen peroxide (H2O2) gas. Slowing production rate AHL-degrading enzyme, AiiA, generates stable fixed states, limit cycle...
The aim of the work is to conduct a performance analysis and, on its basis, indicate most user-friendly and fastest operating framework. Three Internet applications have been written test speed operation selected technologies. Some popular frameworks were analyzed: Angular, React Vue. Static comparative criteria used in are: favorable generally available documentation, application development, development support by creators. practical are times measured during execution tests. tests...
Pacemaker interactions can lead to complex wave dynamics seen in certain types of cardiac arrhythmias. We use experimental and mathematical models pacemakers heterogeneous excitable media investigate how pacemaker be a mechanism for break reentrant dynamics. Embryonic chick ventricular cells are cultured invitro so as create dominant central site that entrains other the medium. Exposure those cultures potassium channel blocker, E-4031, leads emergence peripheral compete with each pacemaker....
Waves of excitation through excitable media, such as cardiac tissue, can propagate plane waves or break up to form reentrant spiral waves. In diseased hearts be associated with fatal arrhythmias. this paper we investigate the conditions that lead wave break, reentry, and propagation failure in mathematical models heterogeneous media. Two types heterogeneities are considered: sinks regions space which voltage is fixed at its rest value, breaks nonconducting no-flux boundary conditions. We...
The contact area between the filler and polymer is a critical region that influences to great extent filler–matrix adhesion therefore mechanical properties of composite. Controlling type interactions at this interface has significant effect on composite materials. In context, we prepared composites by covalent reaction diazonium‐functionalized zeolite with phenol‐formaldehyde resin. Introducing hydroxymethyl groups onto surface via diazonium chemistry allows for bonds resin modified filler....
In this study, the rheological parameters as well Flory–Huggins parameter determined by Inverse Gas Chromatography (IGC) were applied for assessment of changes occurring during storage resole resin and their composites. It was proved that its composites at low temperature (about 10°C) can slow significantly process aging. Main idea research to determine time dependence properties resin. These data should enable extend shelf life containing products. The samples studied determination flow...
Pacemakers in excitable media generate waves that propagate outward from the pacemaker. Such of excitation are well known biological and chemical systems such as nerves, heart, Belousov–Zhabotinsky reaction. Stimuli delivered at a distant site pacemaker can reset pacemaker, leading to change timing The relation between stimulus resultant resetting is captured by phase curves. continuity curves has been investigated both experiments numerical models. We present theoretical results discussing...
Interactions of a spiral wave with pacemaker is studied in mathematical model two dimensional excitable medium. Faster pacemakers emitting target waves can abolish spirals by driving them to the border Our study shows that slower modify behavior changing motion core. We analyze dynamics near core and away from as function size period pacemaker. The cause drift towards it, either speed up or slow down reentrant activity. Furthermore, induced result irregular quasiperiodic even at sites These...
Abstract Depletion of arginine represents an important mechanism immunosuppression, and high plasma tumor arginase (ARG) activity has been demonstrated in patients with a wide spectrum cancers correlated poor prognosis. Low levels inhibit proliferation activation cytotoxic T NK cells. Preclinical clinical studies show that simultaneous interference multiple mechanisms immunosuppression results strongly improved antitumor efficacy. In this context, we have developed OAT-1746, novel, potent,...
The yeast galactose network has provided many insights into how eukaryotic gene circuits regulate metabolic function. However, there is currently no consensus model of the that incorporates protein dilution due to cellular growth. We address this by adapting a well-known and having it account for growth benefit burden expression proteins. Modifying incorporate transport basal Gal1p production allows us better reproduce experimental observations. Incorporating rate effect demonstrates native...