Background: Titanium alloys are widely used in medicine due to their high biocompatibility, corrosion resistance and mechanical strength. However, standard titanium implants have a limited ability integrate with bone tissue, which can lead various complications the need for revision operations. Modification of implant surface biologically active compounds is promising direction solving this problem. Among possible approaches, special attention should be paid use inorganic coatings such as...

Titanium membranes and meshes are used for the repair of trauma, tumors, hernia in dentistry maxillofacial abdominal surgery. But such demonstrate limited effectiveness integration recipients due to their bioinertness. In this study, we prepared titania oxide (by microarc oxidation) and/or HAp electrophoresis deposition) coatings with alginate soaking. We annealing at 700 °C 2.5 h crystallinity increasing achievement an acceptable Ca2+ release rate. The feedstock were characterized by X-ray...

Low-temperature ceramics based on magnesium calcium phosphate cement are a promising resorbable material for bone tissue restoration with the possibility of functionalization. The replacement Mg2+ ion Ca2+ at stage preparation precursor leads to production multiphase containing phases brushite, monetite, and newberyite, different dissolution rates. Multiphase volumetric resorption preservation their geometric shape, which was confirmed by results an evaluation output ions into contact...

Ceramic samples based on β-calcium pyrophosphate β-Ca2P2O7 were prepared from powders of γ-calcium γ-Ca2P2O7 with preset molar ratios Ca/P = 1, 0.975 and 0.95 using firing at 900, 1000, 1100 °C. Calcium lactate pentahydrate Ca(C3H5O3)2⋅5H2O monocalcium phosphate monohydrate Ca(H2PO4)2⋅H2O treated in an aqua medium mechanical activation conditions to prepare powder mixtures containing calcium hydrophosphates 1 (precursors Ca2P2O7). These non-reacted starting salts heat-treated 600 °C after...

Despite a long period of application metal implants, carbon-carbon medical composites are also widely used for bone defect prosthesis in surgery, dentistry, and oncology. Such implants might demonstrate excellent mechanical properties, but their biocompatibility integration efficiency into the host should be improved. As method enhancing, electrophoretic deposition fine-dispersed hydroxyapatite (HAp) on porous carbon substrates recommended. With electron microscopy, energy dispersion X-ray...

The rate of resorption calcium phosphate self-hardening materials for bone regeneration can be changed by changing the phase composition. Ca3(PO4)2/CaCO3/Ca(H2PO4)2·H2O/Na2HPO4·12H2O system is important synthesis self-curing bioactive with variable rates ratios initial components. Cement compositions in twelve figurative points a four-component composition diagram at fixed content α-Ca3(PO4)2 were studied XRD, FTIR, SEM, calorimetric, and volumetric methods to obtain an idea effect on...

Ceramic materials in Na2O-CaO-P2O5 system were obtained by firing cement-salt stone made from pastes based on powder mixtures including calcium citrate tetrahydrate Ca3(C6H5O7)2∙4H2O, monocalcium phosphate monohydrate (MCPM) Ca(H2PO4)2∙H2O and/or sodium dihydrogen NaH2PO4. The phase composition of the samples after adding water, hardening and drying included brushite CaHPO4∙2H2O, monetite CaHPO4 also unreacted ceramics was formed due to thermal conversion hydrated salt heterophase reactions...

Carbonated hydroxyapatites (CAp) are very close to natural bone apatite in chemical composition and regarded as a prospective mineral substitute for surgery orthopedics. However, until now, the studies applications of CAp were limited because amorphous nature synthetic CAp. In present work, microsized highly crystalline carbonated apatites with uniform hexagonal (hCAp) or platelike (pCAp) morphology have been studied first time vitro vivo, comparing against commercial hydroxyapatite (HAp)...

Composite cements containing brushite, monetite and newberyite as dominating phases were created used drug (vancomycin) carriers. Brushite-monetite-newberyite cement with variable composition was obtained by replacing Ca2+ ions Mg2+ in the initial component. Starting powder mixtures for preparation synthesized via solid state reaction consisted of MgxCa(3-х)(PO4)2 (x = 0, 0.75, 1.5, 2.25, 3), monocalcium phosphate monohydrate Ca(H2PO4)2·H2O without vancomycin antibacterial agent. 100 mg a...

Background: This article describes the protocol for purification of xenogenic bone matrix tested by a team authors in «Determining effectiveness xenogeneic decellularization vitro and vivo studies» (the test results were described journal N.N. Priorov Journal Traumatology Orthopedics. 2023;30(4):431–443, doi: https://doi.org/10.17816/vto622849). AIM: To conduct comparative analysis methods physical chemical spongy tissue tomographic morphological studies. MATERIALS AND METHODS: Xenogenic...

Background: Improvement of the technology for manufacturing ultra-high molecular weight polyethylene remains one priority tasks medical technology, because endoprosthesis liner is weakest elements artificial joints, being most frequent cause their damage or destruction. Reinforcement with fillers allows to extend service life products made it by reducing wear rate and friction coefficient various pairs. Aim: To study effect ultra-low content graphite nanoplatelets in concentrations...

Local drug delivery systems are an effective approach in the treatment of purulent–septic inflammation bone tissue. Chemically bonded multiphase ceramics based on calcium-deficient carbonate-substituted hydroxyapatite combine resorbability, osteoconductivity, and possibility volumetric incorporation antibiotics. Macroporosity is regulated by concentration polyethylene glycol granules introduced into initial powder composition, followed their extraction. The selected conditions for...

Ceramics based on rhenanite CaNaPO4 with density of 0.94 g/cm3 and compressive strength 10.3 MPa was obtained via firing at 900 °C composite cement-salt stone prepared from a hardening powder mixture calcium citrate tetrahydrate Ca3(C6H5O7)2∙4H2O sodium dihydrogen phosphate NaH2PO4. The phase composition the samples cement–salt represented by monetite CaHPO4, unreacted tetrahydrate. According to XRD data, ceramic after annealing in temperature range 500–700 mainly β-CaNaPO4 phase. It found...

Biocompatibility of ceramic materials in CaO-P2O5 system was investigated using different methods, including vitro and vivo tests. Ceramics based on calcium pyrophosphate Ca2P2O7 were obtained by annealing cement-salt stone from highly concentrated hardening suspensions (HCHS). Cement-salt prepared powder mixtures citrate tetrahydrate Ca3(C6H5O7)2·4H2O monocalcium phosphate monohydrate (MCPM) Ca(H2PO4)2·H2O. These salts mixed with each other such a way that...

BACKGROUND: Restoration of tissue integrity, including bone tissue, is currently an extremely urgent task, both because the increasing number high-energy traumas accompanied by severe skeletal injuries and growing revision endoprosthetics requiring use bone-plastic materials. AIM: To determine efficacy developed protocol for decellularization xenogenic matrix in preclinical vitro studies aimed at defining purification degree, on basis histological, microtomographic evaluation, cell culture...

The purpose of this study is to analyze the prospects for use local cryotherapy in bone remodeling. Intense cooling causes a response. To evaluate effectiveness cryostimulation defect vivo model Wistar rats, through defects 2 mm diameter were formed. animals subjected 1 and per week. average temperature skin surface decreased from 28 14 C. decrease inside biological tissue near was 5.3C. Microcomputer tomography histological analysis showed that times week an effective method. results...