A5108059694- Membrane Separation Technologies
- Supramolecular Self-Assembly in Materials
- Mesoporous Materials and Catalysis
- Supramolecular Chemistry and Complexes
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Polymer Surface Interaction Studies
- Surface Modification and Superhydrophobicity
- Nanomaterials for catalytic reactions
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Organic Electronics and Photovoltaics
- Solar-Powered Water Purification Methods
- Glycosylation and Glycoproteins Research
- vaccines and immunoinformatics approaches
- Membrane-based Ion Separation Techniques
- Ovarian function and disorders
- Phosphorus and nutrient management
- Medicinal Plants and Neuroprotection
- Assisted Reproductive Technology and Twin Pregnancy
- Acupuncture Treatment Research Studies
- Carbohydrate Chemistry and Synthesis
- Nanoplatforms for cancer theranostics
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Sensor and Energy Harvesting Materials
Ningbo Academy of Agricultural Sciences
2024
Nanjing University
2013-2023
Changzhou University
2021
Nanjing Tech University
2020-2021
Nanjing General Hospital of Nanjing Military Command
2016-2020
Nanjing Medical University
2020
Learning to let go: Controlled release of cargo (purple cubes) from lectin (blue squares)-gated nanopores was achieved using mannose (green loops)-functionalized mesoporous silica (see scheme). The protein nanogates could be opened either by decreasing the pH buffer or adding competing glucose (yellow rings) pores.
Abstract Novel supramolecular vesicles based on host–guest systems were coassembled from carboxylate‐substituted pillar[6]arene (CPA[6]) and disulfide‐linked benzimidazolium amphiphiles, the microstructures of CPA‐based clearly elaborated. The showed controlled drug release in response to five stimuli, with glutathione, pH, CO 2 , Zn 2+ ions, hexanediamine, leading cleavage disulfide bonds, protonation carboxylate groups, metal chelation, competitive binding. This is first case a smart...
Hollow mesoporous silica spheres gated with ZnO quantum dots <italic>via</italic> covalent linkages containing disulfide bonds were constructed for the controlled release of drugs in response to pH and reducing agents.
Imprinted monolayers have several advantages over bulk imprinted polymers such as excellent mass transfer of molecules into and out sites transduction binding signals detected in real time. Protein-imprinted self-assembled (SAMs) were created with multiple biocompatible cavities from functional thiols novel disulfide compounds containing an oligoethylene glycol (OEG) terminal moiety two amide groups incorporated the chain (DHAP) a biologically benign solution. DHAP played important role...
To explore the diversity and promising applications of pillararene-based molecular machines, phosphonated pillar[5]arenes (PPA[5]) were synthesized to construct novel supramolecular nanovalves for first time, based on mesoporous silica nanoparticles (MSNs) functionalized with choline pyridinium moieties, respectively. PPA[5] encircled or stalks encapsulation drugs within MSN pores. showed a high binding affinity quaternary ammonium through host–guest interactions primarily via ion pairing...
A facile and sensitive glucose sandwich assay using surface-enhanced Raman scattering (SERS) has been developed through the use of self-assembled p-mercaptophenylboronic acid (PMBA) monolayer on a smooth gold-coated slide SERS tags Ag nanoparticles (AgNPs) modified with p-aminothiophenol (PATP) PMBA. The photocoupling product 4,4'-dimercaptoazobenzene (DMAB), generated in situ from PATP AgNP surface during measurement, possessed considerably intense characteristic peaks acted as actual...
The synthesis and host-guest chemistry of pillararene (PA) derivatives are a hot research topic, the applications PAs in relevant fields essential to explore. Carboxylate-substituted pillar[6]arene (CPA[6])-valved mesoporous silica nanoparticles (MSNs) functionalized with dimethylbenzimidazolium (DMBI) bipyridinium (BP) stalks were constructed, respectively, for multiresponsive controlled release. CPA[6] encircled DMBI or BP develop supramolecular nanovalves encapsulation cargo within MSN...
Two novel stimuli-responsive drug delivery systems (DDSs) were successfully created from bovine serum albumin- or myoglobin-gated upconversion nanoparticle-embedded mesoporous silica nanovehicles (UCNP@mSiO2) via diselenide (Se–Se)-containing linkages. More importantly, multiple roles of each scaffold the achieved. The controlled release encapsulated doxorubicin (DOX) within mesopores was activated by triple stimuli (acidic pH, glutathione, H2O2) tumor microenvironments, owing to...
The formidable challenge of membrane fouling and wetting, spurred by the elevated concentration pollutants in landfill leachate concentrate during distillation, necessitates substantial costs on cleaning for retaining high separation efficiency. Herein, a durable superhydrophobic poly(vinylidene fluoride) (PVDF) constructed spray-coating fluorinated SiO2 nanoparticles was proposed to treat via distillation. influence operational parameters, including transmembrane temperature difference,...
Membrane distillation (MD) has been widely used for resource recovery from high-salinity wastewater, due to its superior technical merits of high separation efficiency and potential integration low-grade heat. Herein, a robust superhydrophobic PVDF membrane prepared by spray-coating fluorinated silica nanoparticles was employed treat highly saline dye wastewater MD. Specifically, impacts operation conditions, including temperature difference, feed flow-rate, salinity, concentration, species,...
Macht hoch die Tür: Eine Fracht (rosa Würfel) kann gezielt aus den durch Lectin (blaue Quadrate) verschlossenen Nanoporen eines mit Mannose (grüne Schlaufen) funktionalisierten mesoporösen Siliciumdioxids freigesetzt werden (siehe Schema). Die Proteinnanogatter können entweder pH-Senkung des Puffers oder Zusatz von Glucose (gelbe Ringe) als konkurrierendes Agens geöffnet werden, um Poren zu entlassen. As a service to our authors and readers, this journal provides supporting information...
Abstract Novel supramolecular vesicles based on host–guest systems were coassembled from carboxylate‐substituted pillar[6]arene (CPA[6]) and disulfide‐linked benzimidazolium amphiphiles, the microstructures of CPA‐based clearly elaborated. The showed controlled drug release in response to five stimuli, with glutathione, pH, CO 2 , Zn 2+ ions, hexanediamine, leading cleavage disulfide bonds, protonation carboxylate groups, metal chelation, competitive binding. This is first case a smart...
This study aimed to elucidate the effect of electroacupuncture treatment on preventing early ovarian hyperstimulation syndrome (OHSS) and potential mechanisms involved using an induced rat model. The response was examined by measuring ovary weight, vascular permeability, levels inflammation (interleukin-6), tumour necrosis factor alpha, chemokine ligand 2 (also known as monocyte chemoactic protein 1), endothelial growth hormone concentrations (oestradiol, progesterone, testosterone...
Many factors were reported associated with the pregnancy rate of intrauterine insemination (IUI), which played key role is still debated.The aim this study was to explore related clinical outcome factor in IUI cycles non-male factor.The data 1232 690 couples experiencing infertility who attended Reproductive Center Jinling Hospital between July 2015 and November 2021 retrospectively analysed.Female male age, body mass index (BMI), anti-Müllerian hormone (AMH), semen parameters before after...
Stimuli-responsive drug delivery systems are highly desirable for improved therapeutic efficacy and minimized adverse effects of drugs. Mesoporous silica nanoparticles (MSNs) functionalized with pentadentate ligands, N-(3-trimethoxysilylpropyl)ethylenediamine triacetate (TSP-DATA), in the presence metal ions without myoglobin (Mb)-containing surface-accessible histidine residues, were constructed pH-triggered controlled release. The DATA ligands immobilized on MSN pore outlets could...
The SARS-CoV-2 outbreak has spread rapidly and widely since December 2019, the effective drugs are urgently needed. two key proteins, Mpro Spike, attractive therapy targets for developing against infection. In this study, we searched potential inhibitors targeting Spike based on protein sequences structural pharmacological analysis. We found that both of were homologous with bat SARS-like-CoV. showed high conservation (sequence similarities >99%), existing few point mutants in different...