A5010191515- Spinal Cord Injury Research
- Exercise and Physiological Responses
- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Receptor Mechanisms and Signaling
- Biological Activity of Diterpenoids and Biflavonoids
- Muscle Physiology and Disorders
- Probiotics and Fermented Foods
- Chromatin Remodeling and Cancer
- Urinary and Genital Oncology Studies
- Muscle metabolism and nutrition
- Prostate Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Pelvic floor disorders treatments
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Nanoparticles: synthesis and applications
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Neuroprotection
- Diet, Metabolism, and Disease
- Urinary Bladder and Prostate Research
- Retinoids in leukemia and cellular processes
University of the Incarnate Word
2020-2024
Universidad Nacional Autónoma de México
2022-2023
Instituto Politécnico Nacional
2017-2022
Abstract Background The age-related decline in mass, strength, and performance of skeletal muscle is associated with loss independence, falls risk, disability, institutionalization, death. Methods To determine whether a cocoa supplement enriched flavonoids can improve plasma markers oxidative stress inflammation, physical frailty middle-aged older subjects, we conducted two-phase, randomized, double-blind, clinical trial. initial study included 60 subjects (55- to 70-year-old) allocated into...
Mild cognitive impairment (MCI) is defined as an intermediate stage between normal age-related decline and pathological deterioration associated with aging, which course alterations in one or more domains could progress to a major neurocognitive disorder; we investigate five critical proteins involved the pathophysiological process of MCI: Glycogen synthase 3-β (GSK3β), β-secretase (BACE1), Glutamate transporter protein 3–18 (GTRAP3-18), Pregnane X receptor (PXR), epidermal growth factor...
Breast cancer remains to be the second leading cause of deaths worldwide thereby highlighting critical need find superior treatment strategies for this disease. In current era treatment, personalized medicine is garnering much attention as type more selective minimizing harmful side effects. Personalized dependent upon knowing underlying genetic landscape initial tumor. our study, we focused efforts on a specific subset breast that harbors alterations in Mediator subunit 12 (MED12). Our...
Treating addiction and withdrawal syndrome remains a research area of great interest since it is persistent public health problem. Opiates account for the majority problems (at least 56% reported people who consume drugs). Development opiate results mainly from activation mu-opioid receptor (MOR), this entity identified as major target treatment syndrome. Based on our in silico analysis calculations binding energy, conformations adopted by catechins contacts reached ligand could explain why...
Spinal Cord Injury (SCI) is a condition that produces partial or total loss of physiological functions below the lesion. SCI typically leads to severe muscle atrophy, which limits recovery from SCI. With fiber size diameter reduced as cell mass decreases through increased protein turnover/degradation, organelles and cytoplasm. Muscle atrophy after can produce diversity system stressors, including neural inactivity, elevated glucocorticoid levels notable metabolic imbalances. Treatment such...
There is a critical need for superior breast cancer treatment since this disease remains the second leading cause of deaths among American women. Though radiation and chemotherapy have been frontline choice over past few decades, due to detrimental side effects, personalized rapidly rising as method. This largely recent advances in genome‐wide DNA sequencing that allowed identification cancer‐related mutational landscapes. Through these technologies, MED12, subunit Mediator protein, has...
Breast cancer currently ranks second in leading causes of death women the United States. It is estimated that one eight will develop breast over course their life, so finding treatment options for this disease critical. Current strategies include chemotherapy, radiation, and surgery, all which can cause harmful side effects be damaging to patient's overall health. Furthermore, these are not always effective, personalized has become an area interest those who searching alternative options....
Prostate cancer is the most common malignancy and second leading cause of associated deaths among US men. As an androgen-driven disease, prostate critically dependent upon androgen receptor (AR) signaling. Accordingly, patients respond very well to deprivation therapy. The current problem lies with fact that nearly all progress a lethal form disease after therapy known as castration resistant (CRPC). Once reach stage CRPC, treatment options are frustratingly limited average survival times...