A5071943270- Spinal Cord Injury Research
- Estrogen and related hormone effects
- Menopause: Health Impacts and Treatments
- Nerve injury and regeneration
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Phytoestrogen effects and research
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Sensor and Energy Harvesting Materials
- Stress Responses and Cortisol
- Conducting polymers and applications
- Redox biology and oxidative stress
- Hypothalamic control of reproductive hormones
- Autophagy in Disease and Therapy
- Papaya Research and Applications
- Mesenchymal stem cell research
- Traumatic Brain Injury Research
- Medicinal Plants and Neuroprotection
- Nerve Injury and Rehabilitation
- RNA Research and Splicing
- Supramolecular Self-Assembly in Materials
- Eicosanoids and Hypertension Pharmacology
- Electrospun Nanofibers in Biomedical Applications
- Neuroendocrine regulation and behavior
- Molecular Biology Techniques and Applications
Mexican Social Security Institute
2017-2025
Centro Medico Nacional Siglo XXI
2017-2024
Hospital de Especialidades
2017-2024
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2017
Universidad Nacional Autónoma de México
2002-2016
Spinal cord injury (SCI) can cause paralysis, and although multiple therapeutic proposals have been developed in murine models, results hardly replicated humans. As non-human primates (NHP) are more similar to humans than rodents, the current study investigated whether it was possible reproduce a NHP, previously obtained beneficial by using plasma-synthesized polypyrrole/iodine (PPy/I) biopolymer, which reduce glial scar formation inflammatory response promotes nerve tissue preservation,...
Introduction Spinal cord injury (SCI) can cause paralysis, for which effective therapeutic strategies have not been developed yet. The only accepted strategy patients is rehabilitation (RB), although this does allow complete recovery of lost functions, makes it necessary to combine with such as plasma-synthesized polypyrrole/iodine (PPy/I), a biopolymer different physicochemical properties than PPy synthesized by conventional methods. After SCI in rats, PPy/I promotes functional recovery....
In addition to oxidative stress due the increase of free radicals, estrogen deficiency is associated with changes in enzymatic activity, glutathione redox ratio (GSH/GSSG), and content markers such as malondialdehyde. Tibolone, a synthetic steroid, has been used an elective treatment for relief menopausal symptoms. However, acute effects hormonal therapy tibolone on metabolic parameters first stages are still unknown. The study aimed evaluate if administration reduces ovariectomized rats fed...
Inflammation and oxidative stress are critical events involved in neurodegeneration. In animal models, it has been shown that chronic consumption of a hypercaloric diet, which leads to inflammatory processes, affects the hippocampus, brain region fundamental for learning memory processes. addition, advanced age menopause risk factors Hormone replacement therapy (HRT) ameliorates symptoms. Tibolone (TB), synthetic hormone, exerts estrogenic, progestogenic androgenic effects on different...
Spinal cord injury (SCI) harms patients' health and social economic well-being. Unfortunately, fully effective therapeutic strategies have yet to be developed treat this disease, affecting millions worldwide. Apoptosis autophagy are critical cell death signaling pathways after SCI that should targeted for early interventions mitigate their adverse effects promote functional recovery. Tibolone (TIB) is a selective tissue estrogen activity regulator (STEAR) with neuroprotective properties...
Different pyrrole and allylamine polymeric materials, were synthesized by plasma polymerization with different powers doped iodine. The polymers characterized physicochemically. A cell line of neuronal origin (N1E-115) was cultured on them to evaluate the effects materials differentiation. Following a differentiation stimulus, immunofluorescence performed, lengths neurites, as well complexity network formed number nuclei, measured analyzed provide index. results showed that exhibited...
Gonadal steroids exert different effects on the central nervous system (CNS), such as preserving neuronal function and promoting survival. Estradiol, progesterone, testosterone reduce loss in CNS animal models of neurodegeneration. However, hormone replacement therapy has been associated with higher rates endometrial, prostate, breast cancer. Tibolone (TIB), metabolites which show estrogenic progestogenic effects, is an alternative to this risk. impact TIB memory learning, well choline...