// Huihong Jiang 1, * , Huaguang Li 2, Ajian 3 Erjiang Tang 2 Dan Xu Yin Chen Yong Zhang Min Zhiyong 4 Xiaxing Deng 1 Moubin Lin Department of General Surgery, Ruijin Hospital Affiliated to Shanghai Jiaotong University School Medicine, Shanghai, China Center for Translational Yangpu Tongji Zhuji People's Zhejiang Province, Zhejiang, These authors have contributed equally this work Correspondence to: Lin, email: lmbin@hotmail.com Deng, xiaxingdeng@126.com Keywords: colorectal cancer, HALP,...

Objective To investigate the usefulness of serum chromogranin A (CgA) for prediction tumor burden, therapeutic response, and nomogram-based survival in well-moderate nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) with liver metastases (LMs). Materials methods This prospective study included 51 NF-PNETs LMs patients, 134 other tumors, 125 controls. Serum CgA levels were determined by enzyme-linked immunosorbent assay at baseline after treatment. burden was computed simultaneously...

Background: Albumin-to-globulin ratio (AGR) and the prognostic nutrition index (PNI) are used to assess nutritional status severity of disease for a cancer patient. However, clinical significance combining these two predictors in gastric (GC) remains unclear. This study evaluated value pretreatment serum AGR PNI GC.Methods: A total 273 patients with GC, diagnosed between January 2010 2014, were enrolled. The association AGR, clinicopathological characters prognosis assessed by Cox regression...

The 5-year survival rate of cancer patients is the most commonly used statistic to reflect improvements in war against cancer. This idea, however, was refuted based on an analysis showing that changes over time bear no relationship with mortality.Here we show progress fight can be evaluated by analyzing association between rates and mortality normalized incidence (mortality incidence, MOI). Changes are caused improved clinical management as well changing rates, since latter mask effects...

The purpose of this study was to evaluate a retrograde approach for radiofrequency (RF) ablation ectopic atrial tachycardias (EATs) with an early activation at the His site. This included 12 patients EAT. During tachycardia, earliest recorded site standard catheter setting. Activation mapping performed in right atrium and along mitral annulus aortic root after insertion over ascending aorta. In five patients, (in two superior-lateral three inferior-medial annulus). four these EAT could be...

interleukin-37 (IL-37) is as a natural suppressor of the innate inflammatory and immune responses. It has also been reported to be involved in carcinogenesis metastasis. The present case-control study was designed investigate role serum levels IL-37 patients with gastric cancer.serum were determined using enzyme-linked immunosorbent assay 180 diagnosed cancer 100 healthy controls. association between clinical factors assessed. Univariate multivariate analyses performed prognostic...

BACKGROUND Primary lymphoma of the breast is rare, and primary diffuse large B cell (DLBCL) very rare. This study aimed to identify clinicopathological characteristics treatment associated with prognosis in patients DLBCL breast. MATERIAL AND METHODS A retrospective included clinical data from 46 women a histological diagnosis DLBCL. Patients were staged using Ann Arbor staging criteria, overall survival (OS), progression-free (PFS), international prognostic index (IPI) scores obtained....

BACKGROUND:Systemic inflammatory response and nutritional status are important to the prognosis of patients with colorectal cancer (CRC). This study aimed investigate prognostic value combination preoperative hemoglobin, lymphocyte, albumin, neutrophil (HLAN) in locally advanced CRC (LACRC). MATERIAL AND METHODS:We performed a retrospective analysis 536 LACRC undergoing radical surgery. The HLAN was defined as follow: HLAN=Hemoglobin (g/L)×Lymphocyte (/L)×Albumin (g/L)/Neutrophil (/L)/100....

Ewing's sarcoma (ES) is the most common malignant primary bone tumor in children and adolescents. This study aimed at developing new prognostic markers building a microRNA-mRNA network development of ES.GSE80201 GSE39262 were downloaded from Gene Expression Omnibus (GEO) database. Bioinformatics analysis was used to download process data. The coexpression differentially expressed microRNAs (DEMs) genes (DEGs) selected by using R software. FunRich database utilized perform cellular component...

Purpose. Tumor mutational burden (TMB), microsatellite instability-high (MSI-H), and expression of programmed death ligand-1 (PD-L1) have emerged as predictive biomarkers for responsiveness to immune checkpoint inhibitors (ICIs) in several cancer types. However, patients with negative PD-L1 expression, or stability (MSS), some cases may experience favorable response immunotherapy, there is currently a lack good relevant predictors. We tried introduce peripheral blood markers predicting...

Erythroid leukemia is an uncommon form of acute myeloid (AML) which has previously been associated with a poor prognosis. We present the outcome 27 patients AML-M6 (19 de novo and 8 secondary) treated intensive regimens including bone marrow transplantation (BMT). In group, median age was 30 years (2–72); 5 cases were under 15 years. Remission rate after induction chemotherapy 95%. Consolidation in those achieving remission BMT 82%. Transplant related mortality 36%. Median survival for M6...

<h3>Objective</h3> Restrictive cardiomyopathy (RCM) is among the five major cardio- myopathies. The purpose of this study was to demonstrate clinical features RCM patients and evaluate outcome prognostic predictors these patients. <h3>Methods</h3> Between 2000 2009, 107 (48% male, age 55±18 years² mean follow up 35±28 months) which met strict morphological echocardiographic and/or cardiac magnetic resonance imaging (CMRI) criteria for were included. profile reviewed in detail,...

Abstract Background The goal of this study was to assess whether combining amide proton transfer (APT)-weighted MRI with the Prostate Imaging Reporting and Data System scoring system version 2.1 (PI-RADS V2.1) could increase diagnostic accuracy compared PI-RADS V2.1 alone in predicting clinically significant prostate cancer (csPCa). Methods present retrospectively analyzed data from patients who underwent magnetic resonance imaging(MRI) examinations July 2022 August 2023. All T2-weighted...

In this paper, a generalized optimization problem on the local sphere is established by cone order relation tangent space, and solved an improved conditional gradient method (for short, ICGM). The auxiliary subproblems are constructed directed distance function iteration step size updated Armijo rule, convergence of ICGM proved without convexity objective function. Under assumption convexity, clusters sequence generated to be spherical weakly Pareto solutions (also known as efficient solutions) .

Background Clusterin, a heterodimeric glycoprotein of approximately 80 kDa, exists extensively in human body fluids. The abnormal expression clusterin is closely related to the occurrence, progression, and prognosis tumors. Up now, few studies have focused on testicular cancer. This study describes an extensive exploration presence seminoma.

Clusterin expression has a positive correlation with the occurrence and progression of various types tumors from different genetic backgrounds. Cluster in overexpression may protect tumor cells apoptosis damage caused by autoimmunity or anti-tumor therapy. Using immunohistochemisty, one previous study showed that clusterin protein is down-regulated human testicular seminoma, which highly sensitive to radiotherapy chemotherapy. We thus postulate seminoma differs other tumors. It be cause...

Objective To investigate the relationship between morphologic classification of hepatocellular carcinoma and clinicopathological features prognosis in patients, as well factors affecting patients. Methods The clinical data 119 patients with who received surgical treatment at Drum Tower Hospital from January 2008 to December 2013 were retrospectively analyzed. The tumors all cut into sections thickness 1 cm a coronal plane taken pictures for recording pathological features. divided 4...