A5004840054- Systemic Sclerosis and Related Diseases
- Mast cells and histamine
- Dermatologic Treatments and Research
- Autoimmune Bullous Skin Diseases
- Global Health Workforce Issues
- Global Health and Surgery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Pulmonary Hypertension Research and Treatments
- Salivary Gland Disorders and Functions
- Celiac Disease Research and Management
- Palliative Care and End-of-Life Issues
- Trauma and Emergency Care Studies
- Health and Well-being Studies
- Grief, Bereavement, and Mental Health
- Urticaria and Related Conditions
- Eosinophilic Esophagitis
- Travel-related health issues
- Body Image and Dysmorphia Studies
- Diversity and Career in Medicine
- Chemokine receptors and signaling
- Inflammatory Myopathies and Dermatomyositis
- Primary Care and Health Outcomes
- Healthcare professionals’ stress and burnout
Midwestern University
2013-2022
Cook County Health and Hospitals System
2019
Rush University
2019
Orthopaedic Trauma Association
2019
Salford Royal NHS Foundation Trust
2018
Jewish General Hospital
2010-2017
McGill University
2010-2017
University of Michigan
2006-2012
University of Connecticut
2010
Flinders Medical Centre
2010
Abstract Objective To refine the previously developed scleroderma (systemic sclerosis [SSc]) gastrointestinal tract (GIT) instrument (SSC‐GIT 1.0). Methods We administered SSC‐GIT 1.0 and Short Form 36 to 152 patients with SSc; 1 item was added assess rectal incontinence. In addition, subjects completed a rating of severity their GIT involvement (from very mild severe). Evaluation psychometric properties included internal consistency reliability, test–retest reliability (mean time interval...
Introduction Psychosocial and rehabilitation interventions are increasingly used to attenuate disability improve health-related quality of life (HRQL) in chronic diseases, but typically not available for patients with rare diseases. Conducting rigorous, adequately powered trials these diseases is difficult. The Scleroderma Patient-centered Intervention Network (SPIN) an international collaboration patient organisations, clinicians researchers. aim SPIN develop a research infrastructure test...
Objective. Raynaud’s phenomenon (RP) is an important clinical feature of systemic sclerosis (SSc) for which consistently effective therapies are lacking. The study was designed to assess the safety, tolerability, and efficacy tadalafil, a selective, long acting type V cyclic GMP phosphodiesterase (PDE-5) inhibitor, in this syndrome. Methods. We performed prospective, randomized, double-blind, placebo-controlled, crossover comparing oral tadalafil at fixed dose 20 mg daily period 4 weeks...
Systemic sclerosis (SSc) is characterized by fibrosis and microvascular abnormalities including dysregulated angiogenesis. Chemokines, in addition to their chemoattractant properties, have the ability modulate Chemokines lacking enzyme-linked receptor (ELR) motif, such as monokine induced interferon-γ (IFN-γ) (MIG/CXCL9) IFN-inducible protein 10 (IP-10/CXCL10), inhibit angiogenesis binding CXCR3. In addition, CXCL16 promotes its unique CXCR6. this study, we determined expression of these...
The Scleroderma Patient-centered Intervention Network (SPIN) Cohort is a web-based cohort designed to collect patient-reported outcomes at regular intervals as framework for conducting trials of psychosocial, educational, self-management and rehabilitation interventions patients with SSc. aim this study was present baseline demographic, medical outcome data the SPIN compare it other large SSc cohorts. Descriptive statistics were used summarize characteristics; these compared published...
Objectives. SSc-associated gastrointestinal tract involvement (SSc-GIT) is an important predictor of depressive symptoms. University California at Los Angeles Scleroderma Clinical trial Consortium Gastrointestinal Tract 2.0 (UCLA SCTC GIT 2.0) a 34-item valid instrument that captures symptom severity and impact on quality life. It has seven GI-specific scales total score. The objectives were to assess: (i) whether there association between depressed mood with GI as assessed by the UCLA...
Objective. To provide minimally important difference (MID) estimates for the UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 (UCLA SCTC GIT 2.0) in a longitudinal observational cohort. Methods. We administered to 115 patients with systemic sclerosis (SSc) at 2 timepoints 6 months apart. The has 7 multi-item scales: Reflux, Distension/Bloating, Diarrhea, Fecal Soilage, Constipation, Emotional Well-being, and Social Functioning total score. All scales are scored from 0...
Short term medical missions (STMMs) are a form of unregulated and unsanctioned, grass roots, direct service aid from wealthier countries to low middle income countries. The US leads the world in STMM activity. magnitude monetary man power inputs towards STMMs is not clear. objective this study estimate prevalence physician participation related expenditures cash resources.An online survey solicited information on STMMs. Responses regarding costs were aggregated individual global...
Few studies exist on sexual activity and functioning in female patients with systemic sclerosis (SSc, scleroderma). We studied the patient-reported impact of SSc among patients.101 completed Short Form-36 (SF-36), Female Sexual Functioning Index (FSFI) Function Scleroderma (FSFS) questionnaires.Sixty reported being sexually active (59.4%). Reasons for inactivity included lack a partner (36.6%), personal choice (31.7%), health status respondent's (19.5%). Only 7 subjects (17%) listed...
To describe the magnitude and correlates of discordance between patient physician assessments disease severity in patients with systemic sclerosis (SSc).Subjects were enrolled Canadian Scleroderma Research Group Registry. The outcomes interest global (scales ranging from 0-10). Predictors represented spectrum SSc (skin involvement, Raynaud's phenomenon, shortness breath, gastrointestinal symptoms pain, number fingertip ulcers, tender swollen joints, creatinine, fatigue). results analysis...
Systemic Sclerosis (Scleroderma, SSc) is a disease of unknown etiology characterized by widespread vasculopathy and extracellular matrix deposition leading to fibrosis autoimmune processes. Digital ischemia (digital ulcers (DUs)) the hallmark SSc-related endothelial dysfunction intimal proliferation thrombosis. It happens frequently (30% patients each year) it associated with significant morbidity. This paper summarizes current information regarding pathogenesis, definitions, management,...
The 6-min walk test (6MWT) is a standardized measure of submaximal exercise capacity that has served as the primary outcome in studies pulmonary arterial hypertension. Never fully validated scleroderma, variety data suggest many non-pulmonary aspects scleroderma contribute to its results thereby blunting ability 6MWT change lung function. Although reproducible, lack correlation with measures parenchymal disease demonstrates an insurmountable both construct and content validity. should be...
Background Systemic sclerosis, or scleroderma, is a chronic and rare connective tissue disease with negative physical psychological implications. Sources of emotional distress the impact they have on lives people scleroderma are not well understood. Objectives To gain an in-depth understanding experiences sources for women men living through focus group discussions. Methods Three semi-structured discussions were conducted (two in English, one French) total 22 recruited Scleroderma Society...
BACKGROUND Despite significant attempts to educate civilians in hemorrhage control, the majority remain untrained. We sought determine if laypersons can successfully apply one of three commercially available tourniquets; including those endorsed by United States Military and American College Surgeons. METHODS Preclinical graduate health science students were randomly assigned a windless tourniquet: SAM XT, Combat Application Tourniquet (CAT), or Special Operation Forces Tactical (SOFT-T)....
Sexual dysfunction is common in systemic sclerosis (SSc). Male erectile (MED) has been reported around 80% of subjects and more than half female patients fulfill criteria for diagnosis as sexual arousal Disorder (FSAD). While some evidence supports a role cavernosal fibrosis, abundant data suggest that MED yet another clinical feature SSc related to vasculopathy. The contribution vasculopathy the complex issues less clear. Inhibitors Type V phosphodiesterase are effective men with secondary...
This study determined the prevalence of at-risk drinking in a psychiatric emergency service and compared characteristics functioning drinkers with schizophrenia or bipolar disorder those depression anxiety disorders.Adult patients who entered met criteria were surveyed.A total 148 participants had disorder, 242 anxiety. Twenty-three percent group 22 drank more than recommended limits. The reported experiencing significantly consequences from group. Both groups significant prior few days.This...
Summary Background Short‐term medical missions (STMMs) refer to the provision of direct pro bono services in lower and middle income countries for periods ranging from days a few weeks by physicians rich countries. Survey data have provided limited information on demographic professional profiles as well monetary manpower inputs. Understanding why participate, however, remains incomplete. The study's objective was elicit physicians' motivations directly. Methods Semi‐structured interviews...
Systemic sclerosis- (SSc-) related vasculopathy, as manifested by Raynaud's Phenomenon (RP) and digital ulcers (DUs), is associated with significant impairment of the quality life morbidity. The current vasoactive approach for SSc-RP, although employing vasodilators, entirely off-label. PDE-5 inhibitors improve peripheral circulation, are well tolerated, widely used various forms constrictive vasculopathies. This class medications has become one first lines treatment SSc-RP SSc-DUs among...
The US is the leading sending country for short term medical missions (STMMs), an unregulated and unsanctioned, grass roots form of direct service aid from richer countries to low middle income countries. objective this study profile physicians who go on such by means a survey sample physician population. An online solicited information participation in STMMS as well demographic professional features. Responses were descriptively tabulated multivariate regressions performed model profiles...
Cognitive impairment is common in patients with pain. While symptoms of pain are effectively treated osteopathic manipulative treatment (OMT), the cognitive complaint vastly ignored. Pain-induced dysfunction can be severe and particularly apparent working memory attention. There good reason to expect responsiveness OMT. Previous research has reported effects OMT on related psychiatric outcomes, including relief from depression anxiety, suggesting that may produce more cortical benefits than...