A5034406729- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Cervical and Thoracic Myelopathy
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Heme Oxygenase-1 and Carbon Monoxide
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Pregnancy-related medical research
- Bone fractures and treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Ischemia and Reperfusion
- Bone and Joint Diseases
- Trauma and Emergency Care Studies
- Bone health and treatments
- Emergency and Acute Care Studies
- RNA Research and Splicing
- Scoliosis diagnosis and treatment
- Medical Imaging and Analysis
First Affiliated Hospital of Zhengzhou University
2013-2024
As a conventional complication of sepsis, acute kidney injury (AKI) is characterized by high incidence and mortality. Effective management methods are still lacking. Quercetin belongs to kind flavonoids that exerts many functions, for example anti-inflammation anti-fibrosis. However, its function in sepsis AKI uncertain. Our study therefore set out assess the quercetin mice model induced lipopolysaccharide (LPS) human proximal tubular cells (HK-2), including potential mechanisms. was loaded...
This study aimed to explore the effects of peroxisome proliferator-activated receptor γ (PPARγ) inhibition on fracture healing nonunion and underlying mechanisms. Bone marrow mesenchymal stem cells (BMSCs) were treated with PPARγ antagonist GW9662 (5 μM, 10 μM). Alkaline phosphatase (ALP) staining Alizarin Red S was used assess early stage osteogenesis osteogenic differentiation. (1 mg/kg/day) administered intraperitoneally into rats bone fracture. processes in rat femur model recorded...
Osteoarthritis (OA) is a prevalent degenerative joint disease with lack of effective therapeutic. Chondrocyte ferroptosis contributes to the progression OA. PUM2 shown exacerbate ischemia-reperfusion-induced neuroinflammation by promoting ferroptosis, but its role in OA remains unexplored. Here, primary mouse chondrocytes were stimulated IL-1β mimic chondrocyte injury vitro. And was upregulated cartilage tissues and IL-1β-induced chondrocytes. Silencing alleviated inflammation ECM...
Experimental research suggests that females have a higher survival rate after trauma, although this claim is controversial. This study sought to determine the role of sex on mortality among trauma patients in China.The enrolled 1789 who visited Emergency Intensive Care Unit First Affiliated Hospital Zhengzhou University during 2015 and 2016. A retrospective data analysis was performed sex-based differences blunt trauma. Patients were stratified by age injury severity (using Injury Severity...
Abstract Bioactive nanofibres play a useful role in increasing the efficiency of tissue engineering scaffolds. MicroRNAs (miRs) alone, and combination with scaffolds, can be effective treating bone fractures osteoporosis by regulating many post‐transcriptional cellular pathways. Herein, miR‐181a/b‐1 was incorporated electrospun poly (lactic‐co‐glycolic acid) (PLGA) (PLGA‐miR). After characterization osteoinductive capacity investigated when adipose‐derived mesenchymal stem cells (AT‐MSCs)...
Abstract Sarcoma is a rare malignancy with unfavorable prognoses. Accumulating evidence indicates that aberrant alternative splicing (AS) events are generally involved in cancer pathogenesis. The aim of this study was to identify the prognostic value AS-related survival genes as potential biomarkers, and highlight functional roles AS sarcoma. RNA-sequencing AS-event datasets were downloaded from Cancer Genome Atlas (TCGA) sarcoma cohort TCGA SpliceSeq, respectively. Survival-related further...
Objective To analyze the clinical efficacy between transpedicular wedge osteotomy and transdiscal for thoracolumbar kyphotic deformity.Methods Twenty-three patients who received surgical treatment deformity from March 2009 to 2013 were divided into two groups.All followed up 6-24 months.Thirteen cases in group 1 undervent osteotomy,including 8 males 5 females with an age range 33 58 years,and 10 goup 2 6 4 36 62 years.The pre-and post-operative Cobb angle Japanese Orthopaedic Association...
Objective To compare the influence between fusion (PLIF) and non-fusion (lumbar pedicle screws combined with elastic rod fixation) for lumbar in adjacent stages of degeneration.Methods From June 2009 to October 2012,a total 30 patients degenerative disease were treated.The group treated by PLIF (n =16),and those fixation =14).During a follow-up period 2 3 years,magnetic resonance imaging (MRI) re-examination was done observe degeneration stages.Results Woodend indexes (L5/S1) before after...
Objective To compare the long-term clinical effects between lumber discectomy (LD) and Coflex interspinal dynamic fixation system in treatment of lumbar disc herniation.Methods From January 2009 to May 2013,80 cases herniation were enrolled our study,including 37 subject discectomy,and 43 system.All patients received visual analogue scale (VAS),lumbar Japanese Orthopaedic Association (JOA) score Owestry disability index (ODI) assessment before 12,24,36 48 months after operation.Surgically...