A5010390115- Cardiac electrophysiology and arrhythmias
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Circadian rhythm and melatonin
- Cardiovascular Effects of Exercise
- Pulmonary Hypertension Research and Treatments
- Nutrition and Health in Aging
- Neuroscience and Neural Engineering
- Atrial Fibrillation Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Medical Imaging and Pathology Studies
- Neural dynamics and brain function
- ICT in Developing Communities
- Foreign Body Medical Cases
- Coenzyme Q10 studies and effects
- Neurological and metabolic disorders
- Sexual function and dysfunction studies
- Engineering and Test Systems
- Indian Economic and Social Development
- Aortic Thrombus and Embolism
- Menstrual Health and Disorders
- Nutrition, Genetics, and Disease
Lee Memorial Health System
2024
Clinical Physiology Associates
2024
Manubhai Patel Dental College and Hospital
2023
Vardhman Mahavir Medical College & Safdarjung Hospital
2023
Michigan State University
2021
Cleveland Clinic
2018
Era's Lucknow Medical College and Hospital
2017
University of Kentucky
2007-2016
Aurora St. Luke's Medical Center
2014
Aditya Birla (India)
2014
Hypertension is a major risk factor for developing cardiac hypertrophy and heart failure. Previous studies show that hypertrophied failing hearts display alterations in excitation-contraction (E-C) coupling. However, it unclear whether remodeling of the E-C coupling system occurs before or after disease development. We hypothesized hypertension might cause changes that, turn, induce hypertrophy. Here we tested this hypothesis by utilizing progressive development hypertensive spontaneously...
An 82-year-old man who had undergone Watchman FLX (Boston Scientific) device implantation presented with dyspnea. Multimodality evaluation demonstrated a small fistula from the proximal circumflex artery to left atrial appendage. Anatomically, is close appendage; therefore, it plausible that formation could be late complication of device.
Age-related differences in lumbar contribution to the trunk motion sagittal plane were investigated. Sixty individuals between 20-70 years old five gender-balanced age groups performed forward bending and backward return with slow fast paces. Individuals older than 50 old, irrespective of gender or pace, had smaller those younger this age. The was also female participants male participants, under pace pace. contributions suggest synergy active passive lower back tissues is different above...
Abstract Sleep is a critical process that well-conserved across mammalian species, and perhaps most animals, yet its functions underlying mechanisms remain poorly understood. Identification of genes pathways can influence sleep may shed new light on these functions. Genomic screens enable the detection previously unsuspected molecular processes sleep. In this study, we report results from large-scale phenotyping study sleep-wake parameters for population single-gene knockout mice. Sleep-wake...
ORIGINAL RESEARCH article Front. Physiol., 08 June 2012Sec. Cardiac Electrophysiology https://doi.org/10.3389/fphys.2012.00190
Medical societies and cardiac implantable electronic device (CIED) manufacturers recommend avoiding close or direct contact between the body of transvenous leads ablation catheters used to treat arrhythmias. These recommendations are made despite lack clinical studies. However, target myocardium for successful can be contiguous CIED leads.We examine in vitro effects application radiofrequency (RF) cryo-ablation energy on integrity functionality (excluding pacing electrodes defibrillation...
The purpose of this study was to determine the value transesophageal echocardiography (TEE) in determining presence cardiac manifestations that required anticoagulation patients presenting with acute stroke.Of 626 consecutive stroke who underwent TEE, 188 no obvious etiology for were subcategorized according age. TEE results analyzed findings suggestive a cause embolic stroke, including complex atheromas arch/ascending aorta, patent foramen ovale (PFO), atrial septal aneurysm (ASA), and...
In patients with intraatrial conduction delay and sinus node (SN) dysfunction, pacing Bachmann's bundle (BBR) coronary ostium (CSO) has been suggested to achieve atrial resynchronization potential beneficial impact on fibrillation diastolic heart failure. Clinical studies have not shown superiority of one approach.We studied electrical activation sequence in an open-chest acute canine model normal function 8 mongrel dogs under general anesthesia. Bipolar plunge electrodes were distributed...
Background Sleep is critical to well-being and yet the functions regulation of sleep are poorly understood. Genomic approaches identify genes that influence may provide insight into these processes. Our current study employs a non-invasive, high-throughput piezoelectric system utilizing breathing pattern assess sleepwake phenotypes in large population control single-gene knockout mice; recorded as part Knockout Mouse Phenotype Program (KOMP2) at The Jackson Laboratory, which turn IMPC...
Electrical stability in the heart depends on two important factors; restitution of action potential duration (APD) and memory. Repolarization currents play an role determining APD also affect We determined effects blocking rapid component delayed rectifier (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Kr</sub> ) a quantifiable measure memory, i.e. hysteresis APD, swine. Transmembrane potentials were recorded from right ventricular...
Background:Lichen Planus (LP) is a chronic mucocutaneous inflammatory disease that predominantly affects the oral mucosa, with female predilection. The lesions are characterized by burning and pain which relentlessly affect patient’s quality of life. available treatment approaches for OLP documented to have short term effect potential adverse effects further increases demand novel therapeutic approach severe resistant malignant potential. This double-blind, split-mouth randomized controlled...
Several studies suggest link between repolarization alternans and arrhythmia. A potential target for minimization of amplitude is pharmacological flattening restitution function, which links a diastolic interval (DI) subsequent action duration (APD). While our recent have shown that DI dependent not necessary mechanism alternans, in circumstances nearly invariant activation intervals, contributes to alternans. Determination the degree during stable requires determination gain APD, possible...
Spatially discordant alternans (DA) of action potential durations (APD) is thought to be more pro-arrhythmic than concordant alternans. Super normal conduction (SNC) has been reported suppress formation DA. An increase in velocity (CV) as activation rate increases, i.e. a negative CV restitution, widely considered hallmark SNC. Our aim this study show that it not an for faster rates prevents DA, rather, the ratio short relative long critical DA suppression. To illustrate subtlety, we...
Sex is an integral part of a well-being. Sexual satisfaction the most important component quality life. In management ED overall sexual potential and life needs to be taken care as holistic approach management. The aim study was clinically validate effect NRL/MW/201901 polyhedral Nutraceutical product in ED. clinical efficacy patients suffering from erectile dysfunction evaluated by assessing Quality Erection Questionnaire encounter profile with Intra-vaginal ejaculation latency time, serum...
Many methods for sleep restriction in rodents have emerged, but most are intrusive, lack fine control, and induce stress. Therefore, a versatile, non-intrusive means of that can alter controlled manner could be great value research. In previous work, we proposed novel system closed-loop somatosensory stimulation based on mechanical vibration applied it to the task restricting Rapid Eye Movement (REM) mice [1]. While this was effective, crude prototype did not allow precise control over...
Summary form only given. India lives in villages. If we want to see move on and seen as developed economically, socially technologically then rural has be equally modernized. The government at center states various NGOs corporates have tried from time usher is large scale changes through e-governance. E-governance being used for effective, efficient transparent delivery of citizen services person the bottom social economic pyramid. B-governance infrastructure by design requires efficient,...
DOI: http://dx.doi.org/10.3126/jcmsn.v8i3.8688 Journal of College Medical Sciences-Nepal,2012,Vol-8,No-3, 47-50