Thymoquinone is the major active component derived from Nigella sativa. Methotrexate a folic acid antagonist widely used in clinic. Aim of this study was to investigate possible protective role thymoquinone on testicular toxicity methotrexate. Experiments were performed male C57BL/6 mice (6 weeks old, 20 ± 2 g). The animals divided into four groups with six each group. Equivalent volumes saline injected intraperitoneally (i.p.) control In group, received i.p. dose 10 mg/kg/day for 4 days....

<i>Objectives:</i> To investigate the protective role of thymoquinone (TQ) on unilateral testicular ischemia-reperfusion (I/R) injury in mice. <i>Materials and Methods:</i> Experiments were performed male C57BL/6 mice (8 weeks old, 20–25 g). The animals divided into 3 groups including 6 each group: control (sham), torsion/detorsion (TD) TD+TQ. Mice, except sham-operated group, subjected to left torsion (720° rotation clockwise direction). experiments finished after...

The aim of this study was to evaluate the effect hemiplegia on diaphragmatic movements using motion-mode ultrasonography.23 hemiplegic patients who were diagnosed with a single-hemisphere lesion (mean age 60.5 years; 13 males and 10 females) control group 20 (13 7 all evaluated by ultrasonography. Ultrasonography recordings made amplitude movement during spontaneous deep breathing. underwent lung function tests.When groups compared, forced vital capacity, expired volume in 1 s, maximum...

Abstract Kisspeptin is a recently discovered hypothalamic peptide which plays an important role in the central control of reproductive functions. We have investigated direct and indirect effects kisspeptin on liver oxidative stress young male rats. Twenty‐four rats were divided into four groups ( n = 6/group). First group served as received saline. Kisspeptin‐10 was administered to animals second (20 nmol/rat/day), for period 7 days. Rats given only one dose gosereline (0.9 mg/rat), GnRH...

Acute renal failure due to ischemia-reperfusion (I/R) injury is a common complication in cardiovascular surgery. We determined the influence of tadalafil on I/R model rats. For this purpose, 21 male Wistar albino rats were separated into 3 groups: sham, placebo and tadalafil. A right nephrectomy was performed, left pedicles occluded for 60 min reperfused groups. single dose (10 mg/kg) through an orogastric tube administered group. Tubular atrophy with acute inflammation histology, total...

Introduction. Cyclosporine A, an immunosuppressive agent, is widely used after organ transplantation such as the liver and kidney. However, its widespread use restricted because it has serious toxic effects on Caffeic acid phenethyl ester (CAPE) a natural product with potent anti-inflammatory, antitumor, antioxidant activities, attenuates inflammation lipid peroxidation induced by ischemia-reperfusion injury. The purpose of present study was to investigate CAPE cyclosporine A (CsA)-induced...

ABSTRACTObjective: We have compared the plasma levels of recently discovered peptide hormone nesfatin-1 between patients with panic disorder (PD) and healthy control subjects.Method: The subjects in patient group were selected from who presented to psychiatry outpatient clinic a university hospital diagnosed PD. Healthy similar terms age, gender, weight, BMI constituted this study. Panic-Agoraphobia Scale (PAS) was applied all both groups. Blood samples collected measure level by using ELISA...

Aim. The aim of this study was to determine the effects letrozole (LTZ), an aromatase inhibitor (AI), and melatonin (MLT) on hepatic function oxidative stress in female rats.Material methods. A total 32 rats were divided equally into four groups (n = 8). Control group received saline (0.5 ml/day, oral gavage). LTZ administered by daily gavage at 1 mg/kg dose. + MLT given (1 mg/kg, gavage) plus mg/kg/day, s.c.). mg/kg/day) s.c. injection. activities superoxide dismutase (SOD) catalase (CAT)...

Methotrexate is used to treat certain types of cancer the breast, skin, head and neck, or lung. can cause serious life-threatening side effects on liver, lungs, kidneys, immune system. chemotherapy causes testicular damage in humans. The aim this study was investigate possible protective role erdosteine toxicity methotrexate mice. Twenty-six male mice were divided into four groups as follows: group 1, control; 2, erdosteine-treated; 3, methotrexate-treated; 4, + treated. On first day...

A growing body of evidence now suggested that cyclosporine (CycA)-induced nephrotoxicity is a crucial clinical problem and oxidative stress importantly responsible for its toxicity. Ceftriaxone induced antioxidant effect in brain neuronal tissues against damage although potential on kidney has not been clarified. The aim this study was to evaluate whether ceftriaxone protects CycA-induced injury rats. Twenty-four rats were equally divided into four groups. First group used as control. (200...

The toxic effect of ethanol on the cerebral cortex and protective effects omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats divided into 4 groups. Rats withdrawal groups treated with (6 g/kg/day) for 15 days. Animals ethanol+omega-3 group received (400 mg/kg daily) ethanol. In SOD activity was lower than in animals control group. along SOD, increased. GSH-Px MDA levels all similar. NO significantly decreased as compared to (6.45±0.24...

The aim of this study is to investigate the effects caffeic acid phenethyl ester (CAPE) on isoproterenol (ISO)-induced myocardial injury in hypertensive rats.Rats were divided into 4 groups (n=29): Control group (n=8), L-NNA (NG-Nitro-L-arginine) L-NNA+ISO (L-NNA+isoproterenol) (n=7) and L-NNA+ISO+CAPE (L-NNA+ISO + ester) (n=6). ISO (150 mg/kg/day) was given intraperitoneally (i.p.) once a day for 2 consecutive days (at 12th 13th treatment). NG-Nitro-L-arginine (L-NNA) orally (25 drinking...

Introduction: Severe amitriptyline toxicity may cause cardiac dysrhythmias, severe hypotension, convulsions and CNS depression, including coma. Management with gastric lavage, activated charcoal, alkalinization supportive care mechanical ventilation, antiarrhythmics anticonvulsants, if required, is the general approach. Case report: A 33-year-old woman who has taken overdose antidepressants (amitriptyline tianeptine) was admitted to emergency service. She intubated because she had pure...

ABSTRACTABSTRACTObjective: To determine and compare the plasma nesfatin-1 (a satiety peptide) levels of patients with obsessive compulsive disorder (OCD) healthy control subjects.Method: Plasma 31 OCD (18 females, 13 males) 28 subjects (16 females 12 similar to study group in terms weight, age, gender were measured this study. Severity obsessions compulsions both determined by using Yale-Brown Obsessive Compulsive Scale (Y-BOCS). ELISA method was used measure levels.Results: Median 4.61...

Caffeic acid phenethyl ester (CAPE) is a natural product with potent anti-inflammatory, antitumor and antioxidant activities attenuates inflammation lipid peroxidation induced by ischemia-reperfusion injury. The purpose of the present study was to investigate effects CAPE on isoproterenol (ISO) -induced myocardial infarction.A randomized controlled experimental design used in this study. Rats were divided into four groups treated saline, CAPE, ISO ISO+CAPE. (10 micromol kg/day i.p.) or...

Scorpion stings represent an important and serious public health problem worldwide due to their high incidence potentially severe often fatal clinical manifestations. Children are at greater risk of developing cardiac, respiratory, neurological complications lesser body surface area. Alpha receptor stimulation plays role in the pathogenesis pulmonary edema. Prazosin, a post synaptic alpha blocker, can be recommended as effective drug treatment scorpion envenomations with significant...