A5100748106- Cellular transport and secretion
- Calcium signaling and nucleotide metabolism
- Cancer, Hypoxia, and Metabolism
- Hepatitis B Virus Studies
- Ferroptosis and cancer prognosis
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Ovarian function and disorders
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
- Digestive system and related health
- Abdominal Trauma and Injuries
- Menstrual Health and Disorders
- Antibiotic Use and Resistance
- Diet and metabolism studies
- Lung Cancer Treatments and Mutations
- Click Chemistry and Applications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sexual function and dysfunction studies
- Pediatric health and respiratory diseases
- Gout, Hyperuricemia, Uric Acid
- Amoebic Infections and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Case Reports on Hematomas
- Endometrial and Cervical Cancer Treatments
Xi'an Medical University
2024
Affiliated Hospital of Jiangsu University
2017-2023
Jiangsu University
2015-2023
Xiamen University
2009-2023
LaGuardia Community College
2023
City University of New York
2023
Fuzhou University
2023
Tan Kah Kee Innovation Laboratory
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
The HOPS complex serves as a tethering with GEF activity for Ypt7p in yeast to regulate late endosomal membrane maturation. While the role of is well established cells, its functional and mechanistic aspects mammalian cells are less defined. In this study, we report that RILP, downstream effector Rab7, interacts recruits subunits compartment. Structurally, amino-terminal portion RILP complex. Unexpectedly, interaction independent Rab7. VPS41 subunit was defined be major partner interacting...
Small GTPase Rab36 is homologous to Rab34 with 56% amino acid sequence identity. was characterized as a Golgi-associated Rab protein and regulates lysosomal positioning through interaction RILP; however, the properties functions of have not been investigated. To investigate Rab36, we constructed EGFP-Rab36 wild type, active GTP-bound mutant EGFP-Rab36Q116L negative GDP-bound EGFP-Rab36T71N. Expression type revealed that co-localized Golgi markers GM130, Syntaxin 5 TGN46 in Hela cells,...
AIMTo assess the diagnostic value of FIB-4, aspartate aminotransferase-to-platelet ratio index (APRI), and liver stiffness measurement (LSM) in patients with hepatitis B virus infection who have persistently normal alanine transaminase (PNALT). METHODSWe enrolled 245 chronic B: 95 PNALT group, 86 intermittently elevated (PIALT1) group [alanine (ALT) within 1-2 × upper limit (ULN)], 64 PIALT2 (ALT > 2 ULN).All received a percutaneous biopsy guided by ultrasonography.LSM, biochemical tests,...
Abstract Background Obese patients have been found to be susceptible iron deficiency, and malabsorption of dietary is the cause obesity-related deficiency (ORID). Divalent metal transporter 1 (DMT1) ferroportin (FPN), are two transmembrane proteins expressed in duodenum that closely associated with absorption. However, there few studies on association between these increased susceptibility obese patients. Chronic inflammation also thought a both conditions can an impact spermatogenesis...
ObjectiveTo investigate the effects of a high-fat diet (HFD) on gut bacterium Roseburia intestinalis and butyric acid levels, to assess their impact ovarian function epigenetic markers in mice.MethodsA total 20 female ICR mice aged 4 weeks were randomly assigned two groups fed either control (CD) or an HFD for 36 weeks. Post-intervention, ileal contents analyzed quantification using ELISA, while feces obtained expression assessment via qPCR. Histological evaluations intestinal tissues...
This study investigates the burden of chronic kidney disease attributed to type 2 diabetes (CKD-T2D) across different geographical locations and time periods from 1990 2019. A total 204 countries regions are included in analysis, with consideration given their socio-demographic indexes (SDI). The aim is examine both spatial temporal variations CKD-T2D burden.
Rab26 is known to regulate multiple membrane trafficking events, but its role in insulin secretion pancreatic β cells remains unclear despite it was first identified the pancreas. In this study, we generated -/- mice through CRISPR/Cas9 technique. Surprisingly, levels blood of do not decrease upon glucose stimulation conversely increase. Deficiency promotes secretion, which independently verified by knockdown insulinoma cells. Conversely, overexpression suppresses both cell lines and...
AIM:To investigate the virological relapse rate in hepatitis B e antigen (HBeAg)-negative patients after antiviral therapy discontinuation and analyze factors associated with relapse.METHODS: Among diagnosed chronic infection between May 2005 July 2010, 204 were eligible for analysis.The Kaplan-Meier method log-rank test used to calculate cumulative of compare rates groups.The Cox proportional hazards regression model was evaluate predictive factor relapse. RESULTS:The 2 1 year risks 79.41%...
Objective: Uric acid (UA) is a risk marker of CKD and SUA level in 3–4 patients closely correlates with hyperuricemic nephropathy (HN) morbidity. This study was designed to evaluate the factors for HN patients.Methods: The 461 were recruited all divided into three groups (24 h UUA normal, underexeret, overproduct type groups) according 24 after receiving low purine food five days. Clinical biochemical characteristics collected logistic regression analysis. Correlation analysis mRNA relative...
Recent research revealed methionine metabolism as a key mediator of tumor initiation and immune evasion. However, the relationship between microenvironment (TME) in lung adenocarcinoma (LUAD) remains unknown. Here, we comprehensively analyzed genomic alterations, expression patterns, prognostic values 68 methionine-related regulators (MRGs) LUAD. We found that most MRGs were highly based on 30 datasets including 5024 LUAD patients. Three distinct MRG modification patterns identified, which...
Abstract Background Some studies have stated that intrauterine insemination (IUI) with controlled ovarian stimulation (COS) might increase the pregnancy rate, while others suggest IUI in natural cycle (NC) should be first line of treatment. It remains unclear whether it is necessary to use COS at same time when applied treat isolated male factor infertility. Thus, we aimed investigate efficacy for Methods A total 601 cycles from 307 couples who sought medical care infertility between January...
The objective of the current study was to explore relationship between longitudinal change in body mass index (BMI) and reproductive hormones middle-aged elderly Chinese men. A cohort conducted a rural area China. Local male residents aged 40–80 years were recruited at baseline 2012 followed up 2016. Information about weight, height, waist circumference, sex hormones, smoking status, medical history obtained. BMI reported no significant with total testosterone (TT), calculated free (cFT),...
Matched Field Processing (MFP) and its derivative Mode (MMP) estimates similarity between in-situ measurement the model-based replica to identify source locations from an array of received signals. The is evaluated in ambiguity function using magnitude phase mode coefficients signal. While vulnerable noises interference, we find that phase-difference signals adjacent receivers proves be more robust. We propose use difference as a weighting factor MMP select sensors space domain snapshots...