The rhizome of Oni-dokoro (a wild yam, Dioscorea tokoro) has extremely bitter taste and is not generally regarded edible;, however, in northern part Japan, such as Iwate a Aomori, it used health promoting food. To clarify the reason, we examined biologically active compounds collected at compared them from other area literature.The acetonitrile extract Japan was purified by bioassay-guided separation using antiproliferative activity to human leukemia HL-60 cell, protodioscin (PD) isolated...

Quercetin is a flavonoid with many physiological effects. Absorbed quercetin rapidly conjugated in the intestinal epithelium and liver. Different positional isomers of conjugates have different properties. However, mechanisms conjugation intestine are not fully clarified. We examined regioselective conjugate formation after oral administration glycosides, by simultaneous sampling blood from portal vein superior vena cava, quantifying various glucuronides sulfates conscious rats....

This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting disorders with redness swelling, and, Japan, it is approved prescription acute and/or purulent disorders, hives, eczema, athlete's foot. Considering the use of JHT, we hypothesized that oral administration might emerge as an effective strategy prevent damage, such...

A single high-dose ultraviolet B (UVB) exposure on the skin induces acute inflammatory responses, such as an increase in proinflammatory cytokines (e.g., IL-6 and IL-1β), hyperpermeability dilation of blood lymphatic vessels, infiltration cells. These responses result different cutaneous disorders characterized by erythema, epidermal hyperplasia, edema formation, extracellular matrix degradation. Saireito extract (SRT), a traditional Chinese medicine, has been used to treat various diseases...

Ninjin'yoeito (NYT) is widely used clinically for the management of patients with frailty and other multiple symptoms. NYT often administered drugs; however, little information available on its drug interactions. Previous studies using human liver microsomes have reported that constituents either inhibit (schisandra fruit, cinnamon bark, glycyrrhiza, poria sclerotium) or induce fruit glycyrrhiza) CYP3A4 expression. Herein, we conducted in vitro vivo targeting CYP3A mouse to elucidate effects...

Background: Salix gilgiana is a deciduous tree that grows in northern Japan, the Korean peninsula, eastern Russia along Ussuri River, and northeast China. The stem of this dried consumed orally as folk medicine. Our intensive screening various plant materials found MeOH extract its exhibited significant antiproliferative activity against HL-60 leukemic cells with an IC50 16 ppm. We systematically investigated biologically active compounds S. gilgiana. Methods: was fractionated by repeated...

[Introduction] Ultraviolet (UV) radiation, especially UVB (280-320 nm) from sunlight, is one of major environmental hazard to induce skin damage. A single high dose exposure on the causes acute inflammatory reaction which characterized by erythema, increasing vascular permeability and edema formation. The UVB-induced damage could be accumulated chronic irradiation. lead aging raise risk cancer. Therefore, inhibition inflammation important target for protecting exposure. Sairei-to (SRT), a...

Background: Jumihaidokuto (JHT), a traditional Chinese medicine, has been clinically prescribed for the treatment of patients with skin disorder redness and swelling, such as atopic dermatitis or acne vulgaris. However, it remains unknown how JHT ameliorates disorders. In this study, we investigated effect on UVB-induced inflammation model.

A single high-dose ultraviolet B (UVB) exposure on the skin induces acute inflammatory responses, such as an increase in proinflammatory cytokines, hyperpermeability and dilation of blood lymphatic vessels, infiltration cells. These responses result different cutaneous disorders characterized by erythema, edema formation, extracellular matrix degradation. Saireito (SRT), a traditional Chinese medicine, has been used to treat various diseases Japan. SRT was also suggested improve lymphedema...

This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice.