Ninjinyoeito (NYT), a traditional Chinese medicine consisting of 12 herbs, is designed to improve fatigue, cold limbs, anorexia, night sweats, and anemia. Recently, NYT was reported cognitive outcome depression in patients with Alzheimer's disease. However, little known about how alleviates dysfunction. In this study, we investigated the effects mechanisms corticosterone (CORT)-induced model depression. Chronic treatment ameliorated depressive-like behaviors induced by CORT three types...

With the recent aging of society, prevention frailty has become an important issue because people desire both a long and healthy lifespan. Klotho-hypomorphic (kl/kl) mice are known to show phenotypes premature aging. Ninjin'yoeito (NYT) is traditional Japanese Kampo medicine used treat patients with vulnerable constitution, fatigue or physical exhaustion caused by illness. Recent studies have reported potential efficacy NYT against frailty. We therefore evaluated effect on gait function,...

This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting disorders with redness swelling, and, Japan, it is approved prescription acute and/or purulent disorders, hives, eczema, athlete's foot. Considering the use of JHT, we hypothesized that oral administration might emerge as an effective strategy prevent damage, such...

Abstract Non-alcoholic steatohepatitis (NASH) is a progressive fibrotic form of non-alcoholic fatty liver disease. Liver fibrosis leads to cancer and cirrhosis, drug therapy for NASH remains lacking. Ninjin’yoeito (NYT) has shown antifibrotic effects in model without steatosis but not been studied NASH. Therefore, we evaluated the efficacy NYT mice fed choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) as model. Compared with normal group, CDAHFD showed decreased body weight...

Rheumatoid arthritis is one of the most common diseases in orthopedic surgery. The main symptoms are joint pain and systemic symptoms. In recent years, rheumatoid known to cause sarcopenia. Ninjin'yoeito (NYT), a traditional Japanese medicine, has been prescribed for patients with post-illness or post-operative weakness, fatigue, loss appetite, rash, cold limbs, anemia. addition its use, NYT treating frailty gastrointestinal, respiratory, urinary functions. Further, be effective suppressing...

Alzheimer's Disease (AD) shows cognitive dysfunction as core symptoms and Behavioral Psychological Symptoms of Dementia (BPSD). Since acetylcholine nerve system derived from septum is collapsed in the AD patients, we have used Olfactory Bulbectomized (OBX) mice whose cholinergic largely impaired septum. Recently, Yokukansankachimpihange (YKH), a traditional Japanese Kampo medicine has for BPSD addition to improve patients. However essential components cognition improvement their mechanism...

Cigarette smoke is a major risk factor for various lung diseases, such as chronic obstructive pulmonary disease (COPD). Ninjinyoeito (NYT), traditional Chinese medicine, has been prescribed patients with post-illness or post-operative weakness, fatigue, loss of appetite, rash, cold limbs, and anemia. In addition to its use, NYT treating frailty in gastrointestinal, respiratory, urinary functions. Further, treatment can ameliorate cigarette smoke-induced injury, which destructive index mice;...

The prevalence of chronic obstructive pulmonary disease (COPD) is increasing in the elderly. COPD a respiratory characterized by airway remodeling and alveolar emphysema. patients are also at high risk for mental illnesses such as depression anxiety. Ninjin'yoeito (NYT) prescribed to with conditions post-illness postoperative weakness, fatigue, poor appetite, skin rash, cold hands feet, anemia. In addition traditional uses, NYT therapeutic drug functioning digestive organs, urinary organs....

Weight loss is often temporary and generally followed by recurrent weight gain a relapse of metabolic complications, whose severity may be even greater upon recurrence. Preventing obesity, understanding the control energy balance subsequent to loss, reversing predisposition obesity are critical factors that warrant an in-depth study. Several Kampo medicines, including daisaikoto, have traditionally been used manage but their mechanisms action not well studied effects on regain unknown. Here,...

Kampo medicines are frequently used empirically to treat pain in clinical practice. Ninjin'yoeito (NYT), which is associated with few adverse effects, often the elderly, but has not yet been examined detail. We herein investigated effects of NYT, at 500 and 1,000 mg/kg p.o. (NYT500/NYT1000 group) single repeated administrations for 14 days, on rats peripheral neuropathy induced by loose ligation sciatic nerve (chronic constriction injury: CCI). Untreated CCI given distilled water were as a...

A single high-dose ultraviolet B (UVB) exposure on the skin induces acute inflammatory responses, such as an increase in proinflammatory cytokines (e.g., IL-6 and IL-1β), hyperpermeability dilation of blood lymphatic vessels, infiltration cells. These responses result different cutaneous disorders characterized by erythema, epidermal hyperplasia, edema formation, extracellular matrix degradation. Saireito extract (SRT), a traditional Chinese medicine, has been used to treat various diseases...

Currently, there are limited reports available regarding the treatment and prevention of progressive age-related hearing loss. This is because loss not a critical disease with direct fatalities has several well-established countermeasures such as aids cochlear implants. study evaluated efficacy Ninjinyoeito (NYT) in C57BL/6J mice were divided into three groups: baseline group, untreated NYT-treated latter receiving NYT for 2 months. The fed extract mixed 4% mouse normal chow. Hearing was...

The production of melanin is not only activated by external factors such as sunlight or UV-exposure, but also considered to be triggered hormonal factors, particularly sex hormones ovarian hormones. Previously, keishibukuryoganryokayokuinin (KBY) was reported increase the pigmentation and moisture content dermis in women during luteal phase menstrual cycle, thus suggesting that progesterone could play a critical role development skin pigmentation. In present study, female DBA/2 mice, dilute...

Ninjin'yoeito (NYT) is widely used clinically for the management of patients with frailty and other multiple symptoms. NYT often administered drugs; however, little information available on its drug interactions. Previous studies using human liver microsomes have reported that constituents either inhibit (schisandra fruit, cinnamon bark, glycyrrhiza, poria sclerotium) or induce fruit glycyrrhiza) CYP3A4 expression. Herein, we conducted in vitro vivo targeting CYP3A mouse to elucidate effects...

Herbal medicines, acupuncture and moxibustion are often used for unidentified complaints. It is well known that catecholamine secreted by the sympatho-adrenal medullary system primarily functions to increase cardiac output raise glucose levels in blood during acute stress. In present study, effects of yokukansankachimpihange (YKSKCH, a Kampo medicine) on urinary mice were repeatedly stressed restraining examined. Restraint stress (240 min/d×3 d×3 cycles, daytime: 12:00-16:00) induced marked...

Abstract Skin inflammation and dryness are the features of surfactant-induced irritant contact dermatitis, a common skin disorder. In Japan, Coix seed (CS, lacryma-jobi L. var. ma-yuen Stapf) is widely used as traditional medicine functional supplement to treat dry skin. However, efficacy CS against disorders has not been reported. Here, we investigated effect on inflammatory induced by multiple topical applications sodium dodecyl sulfate (SDS), representative anionic surfactant. Male HR-1...

Yokukansankachimpihange (YKSCH), a traditional Japanese medicine composed of 9 crude drugs, is designed to improve neurosis, insomnia in adults, and night crying children. YKSCH has been reported diurnal rhythm patients with Alzheimer's disease prolong the total sleeping time healthy subjects. However, little known about how alleviates sleep disorders. Here, we investigated whether treatment affected latency duration group-housed socially isolated mice. Male ddy mice were treated [1,500...

[Introduction] Ultraviolet (UV) radiation, especially UVB (280-320 nm) from sunlight, is one of major environmental hazard to induce skin damage. A single high dose exposure on the causes acute inflammatory reaction which characterized by erythema, increasing vascular permeability and edema formation. The UVB-induced damage could be accumulated chronic irradiation. lead aging raise risk cancer. Therefore, inhibition inflammation important target for protecting exposure. Sairei-to (SRT), a...

Background: Jumihaidokuto (JHT), a traditional Chinese medicine, has been clinically prescribed for the treatment of patients with skin disorder redness and swelling, such as atopic dermatitis or acne vulgaris. However, it remains unknown how JHT ameliorates disorders. In this study, we investigated effect on UVB-induced inflammation model.

A single high-dose ultraviolet B (UVB) exposure on the skin induces acute inflammatory responses, such as an increase in proinflammatory cytokines, hyperpermeability and dilation of blood lymphatic vessels, infiltration cells. These responses result different cutaneous disorders characterized by erythema, edema formation, extracellular matrix degradation. Saireito (SRT), a traditional Chinese medicine, has been used to treat various diseases Japan. SRT was also suggested improve lymphedema...

This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice.

Abstract BackgroundCigarette smoke is a major risk factor for various lung diseases, such as chronic obstructive pulmonary disease (COPD). Ninjinyoeito (NYT), traditional Chinese medicine, has been prescribed patients with post-illness or post-operative weakness, fatigue, loss of appetite, rash, cold limbs, and anemia. In addition to its use, NYT treating frailty in gastrointestinal, respiratory, urinary functions. Further, treatment can ameliorate cigarette smoke-induced injury, which...