A5091742589- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Muscle Physiology and Disorders
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Total Knee Arthroplasty Outcomes
- Mitochondrial Function and Pathology
- Osteoarthritis Treatment and Mechanisms
- Nuclear Structure and Function
- Proteoglycans and glycosaminoglycans research
Novartis (Switzerland)
2021-2024
Novartis Institutes for BioMedical Research
2021
Progressive loss of muscle mass and function due to fiber atrophy in the elderly chronically ill is now defined as sarcopenia. It a major contributor independence, disability, need long-term care well overall mortality. Sarcopenia heterogenous disease underlying mechanisms are not completely understood. Here, we newly identified used Tmem158, alongside Cdkn1a, relevant senescence denervation markers (SDMs), associated with atrophy. Subsequent application laser capture microdissection (LCM)...
Dysregulated mRNA splicing is involved in the pathogenesis of many diseases including cancer, neurodegenerative diseases, and muscular dystrophies such as myotonic dystrophy type 1 (DM1). Comprehensive assessment dysregulated on transcriptome proteome level has been methodologically challenging, thus investigations have often targeting only few genes. Here, we performed a large-scale coordinated transcriptomic proteomic analysis to characterize DM1 mouse model (HSA
Abstract Dysregulated mRNA splicing is involved in the pathogenesis of many diseases including cancer, neurodegenerative diseases, and muscular dystrophies such as myotonic dystrophy type 1 (DM1). Comprehensive assessment dysregulated on transcriptome proteome level has been methodologically challenging, thus investigations have often targeting only few genes. Here, we performed a large-scale coordinated transcriptomic proteomic analysis to characterize DM1 mouse model (HSA LR ) comparison...