A5106403338- Cancer-related molecular mechanisms research
- Sarcoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Gene expression and cancer classification
- Genomic variations and chromosomal abnormalities
- Multiple Myeloma Research and Treatments
- Chromosomal and Genetic Variations
- Muscle Physiology and Disorders
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Glycosylation and Glycoproteins Research
- Aluminum Alloys Composites Properties
- RNA Research and Splicing
- Immune Response and Inflammation
- Genetic Neurodegenerative Diseases
- Cancer Genomics and Diagnostics
- Sepsis Diagnosis and Treatment
- Cardiomyopathy and Myosin Studies
- Tumors and Oncological Cases
- Metallurgy and Material Forming
Xinyu University
2024
Novartis (United States)
2009-2023
Jiangxi Agricultural University
2023
Shanghai Jiao Tong University
2021-2022
Shanghai Children's Medical Center
2021-2022
Dana-Farber Cancer Institute
2004-2017
Analysis and Testing Centre
2014
Capital Medical University
2013
Beijing Hospital of Traditional Chinese Medicine
2013
Duke University
2013
Lung cancer is the leading cause of mortality worldwide, yet there exists a limited view genetic lesions driving this disease. In study, an integrated high-resolution survey regional amplifications and deletions, coupled with gene-expression profiling non-small-cell lung subtypes, adenocarcinoma squamous-cell carcinoma (SCC), identified 93 focal copy-number alterations, which 21 span <0.5 megabases contain median five genes. Whereas all known genes/loci are contained in dataset, most...
The pancreatic adenocarcinoma genome harbors multiple amplifications and deletions, pointing to the existence of numerous oncogenes tumor suppressor genes driving genesis progression this lethal cancer. Here, array comparative genomic hybridization on a cDNA microarray platform informatics tools have been used define copy number alterations in panel 24 cell lines 13 primary specimens. This high-resolution analysis has identified all known regional gains losses as well many previously...
Multiple myeloma (MM) is an invariably fatal form of cancer characterized by clonal proliferation malignant plasma cells in the bone marrow. The canonical Wnt signaling pathway activated MM through constitutively active beta-catenin, a messenger molecule relevant to growth, survival, and migration cells. identification number small molecular compounds, such as PKF115-584, which disrupt interaction transcriptionally beta-catenin/TCF protein complex, provides valuable new therapeutic tools...
Abstract Several components of the Wnt signaling cascade have been shown to function either as tumor suppressor proteins or oncogenes in multiple human cancers, underscoring relevance this pathway oncogenesis and need for further investigation potential targets cancer therapy. Here, using expression profiling analysis well vitro vivo functional studies, we show that component BCL9 is a novel oncogene aberrantly expressed myeloma colon carcinoma. We enhances β-catenin–mediated transcriptional...
Abstract In vitro differentiation of human embryonic stem cells (hESCs) into pure cardiomyocytes (hESCMs) would present a powerful tool to further the creation cell models designed advance preclinical drug development. Here, we report novel method substantially increase hESCM yield. Upon early and transient treatment hESCs with Wnt3a, embryoid body mesendoderm formation is enhanced, leading greater toward cardiomyocytes. Moreover, generated beating clusters are highly enriched (50%) express...
Cancer represents the phenotypic end point of multiple genetic lesions that endow cells with a full range biological properties required for tumorigenesis. Among hallmark features cancer genome are recurrent regional gains and losses that, upon detailed characterization, have provided highly productive discovery paths new oncogenes tumor suppressor genes. In this study, we describe use an oligonucleotide-based microarray platform development requisite assay conditions bioinformatic mining...
Embryonic rhabdomyosarcoma (ERMS) is the most common soft-tissue tumor in children. Here, we report identification of minor groove DNA-binding factor high mobility group AT-hook 2 (HMGA2) as a driver ERMS development. HMGA2 was highly expressed normal myoblasts and cells, where its expression essential to maintain cell proliferation, survival vitro, outgrowth vivo. Mechanistic investigations revealed that upregulation insulin-like growth (IGF) mRNA-binding protein IGF2BP2 critical for...
Progressive loss of muscle mass and function due to fiber atrophy in the elderly chronically ill is now defined as sarcopenia. It a major contributor independence, disability, need long-term care well overall mortality. Sarcopenia heterogenous disease underlying mechanisms are not completely understood. Here, we newly identified used Tmem158, alongside Cdkn1a, relevant senescence denervation markers (SDMs), associated with atrophy. Subsequent application laser capture microdissection (LCM)...
Background To explore the diagnostic performance of interleukin (IL)-6 and IL-10 in discriminating Gram bacteria types predicting disease severity intensive care unit (ICU)-hospitalized pediatric sepsis patients. Method We retrospectively collected Th1/Th2 cytokine profiles 146 microbiologically documented Patients were categorized into Gram-positive (G+) or Gram-negative (G-) groups, levels compared. Subgroup analysis was designed to eliminate influence other inflammatory responses on...
Facioscapulohumeral muscular dystrophy (FSHD) is among the most prevalent of adult-onset dystrophies. FSHD causes a loss muscle mass and function, resulting in severe debilitation reduction quality life. Currently, only symptoms can be treated, such treatments have minimal benefit. The available options are not curative, none address underlying cause FSHD. genetic, epigenetic, molecular mechanisms triggering now quite well-understood, it has been shown that expression transcriptional...
Albuminuria is an important marker of nephropathy that increases the risk progressive renal and chronic cardiovascular diseases. The genetic basis kidney disease well-established in humans rodent models, but causal genes remain to be identified. We applied several strategies map refine loci affecting albuminuria mice translated findings human disease. First, we measured from 33 inbred strains, used data for haplotype association mapping (HAM), detected 10 genomic regions associated with...
Key Points Ras pathway activation cooperates with Ink4a/Arf locus deletion in B cells to induce a fully penetrant lymphoma/leukemia phenotype mice. These tumors resemble high-risk subtypes of human B-ALL, providing convenient and highly reproducible model refractory B-ALL.
Camellia oleifera Abel. is an economically important woody edible-oil species that mainly cultivated in hilly areas of South China. The phosphorus (P) deficiency the acidic soils poses severe challenges for growth and productivity C. oleifera. WRKY transcription factors (TFs) have been proven to play roles biological processes plant responses various biotic/abiotic stresses, including P tolerance. In this study, 89 proteins with conserved domain were identified from diploid genome divided...
Soil carbon mineralization plays an important role in the cycle of terrestrial ecosystems. When it comes to soil cycle, however, research on how characteristics fertilized Camellia oleifera forest respond temperature changes remains limited. This study used indoor constant incubation method examine effects vermicomposting cow dung by applying at three different quantities (A: 0.8 kg earthworm + 62.5 dung/Camellia oleifera; B: 1.6 125 C: 2.4 187.5 oleifera) and set a control group with not...
Abstract Background Completion of the human genome sequence along with other species allows for greater understanding biochemical mechanisms and processes that govern healthy as well diseased states. The large size sequences has made them difficult to study using traditional methods. There are many studies focusing on protein coding sequences, however, not much is known about function non-coding regions genome. It been demonstrated parts region play a critical role gene regulatory elements....