A5037831163- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Rheumatoid Arthritis Research and Therapies
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Dental Implant Techniques and Outcomes
- HIV/AIDS oral health manifestations
- Dental Education, Practice, Research
- Dental Research and COVID-19
- Periodontal Regeneration and Treatments
- Dental Health and Care Utilization
- Immunodeficiency and Autoimmune Disorders
- Salivary Gland Disorders and Functions
- Biosimilars and Bioanalytical Methods
- Gastroesophageal reflux and treatments
- Advanced X-ray and CT Imaging
- Dental Trauma and Treatments
- Streptococcal Infections and Treatments
- Eosinophilic Esophagitis
- Genomics and Phylogenetic Studies
- Healthcare Systems and Technology
- Bone and Dental Protein Studies
- Oral and Maxillofacial Pathology
- Health and Medical Education
- dental development and anomalies
University of Leeds
2016-2024
Leeds Dental Hospital
2000-2020
Leeds Teaching Hospitals NHS Trust
2018-2019
Centre For Digestive Diseases
1995
The prevalence of periodontitis is increased in patients with rheumatoid arthritis (RA) and periodontopathic bacteria can citrullinate proteins. Periodontitis may, therefore, be an initiator RA a target for prevention. Periodontal disease periodontal have not been investigated at-risk individuals autoimmunity but no arthritis.To examine anti-cyclic citrullinated protein (anti-CCP) antibody-positive without arthritis.This cross-sectional study took place at teaching hospital from April 27,...
An increased prevalence of periodontitis and perturbation the oral microbiome has been identified in patients with rheumatoid arthritis (RA). The periodontal pathogen Porphyromonas gingivalis may cause local citrullination proteins, potentially triggering anti-citrullinated protein antibody production. However, it is not known if dysbiosis precedes onset clinical arthritis. This study comprehensively characterised anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals...
Sixty two patients (mean age 45.6 years) were assessed for oral hygiene and periodontal disease by dental examination before endoscopy. Information about care, smoking, dentures was obtained samples of plaque collected. The presence Helicobacter pylori in as sought culture polymerase chain reaction (PCR), gastric antral biopsy specimens taken histological examination. Although H detected the 34 (54%) all cultures negative, PCR only positive from one patient. Smokers had poor hygiene, visited...
BackgroundThe studies of the distribution Actinomyces spp. on carious and non-carious root surfaces have not been able to confirm association these bacteria with caries, although they were extensively implicated as a prime suspect in caries.ObjectiveThe aim this study was observe gene expression microbiota without caries.DesignThe oral biofilms from exposed sound surface (SRS; n=10) active caries (RC; n=30) samples collected. The total bacterial RNA extracted, mRNA isolated. Samples low...
Introduction. Oral tissues are generally homeostatic despite exposure to many potential inflammatory agents including the resident microbiota. This requires balancing of inflammation by regulatory mechanisms and/or anti-inflammatory commensal bacteria. Thus, levels bacteria in populations may be critical maintaining this balance. Hypothesis/Gap Statement. The incidence immunosuppressive streptococci oral cavity is not well established. Determining proportion these organisms and involved help...
Radiographs are commonly used in the diagnosis of periodontal diseases. They can be to assess bone loss and pattern as well identification other periodontally relevant features, such overhanging restoration margins, calculus deposits furcation lesions. Horizontal vertical bitewings, panoramic radiographs periapicals for assessment. Referral (selection) criteria based on clinical signs assist decision use. All exposures must made accordance with Ionizing Radiation (Medical Examination)...
Background: The prevalence of periodontal disease and the citrullinating bacterium Porphyromonas gingivalis are increased in anti-CCP positive individuals at-risk rheumatoid arthritis (RA) (1). This suggests inflammation may have an important role initiation development RA. Despite significant interest periodontium other mucosal sites RA-related autoimmunity, influence on progression to inflammatory (IA) remains unclear. Objectives: To investigate association between periodontitis anti-CCP+...
To assess current radiographic practices in dental teaching hospitals for the management of patients with periodontal diseases.All 17 UK and Ireland were sent a questionnaire on equipment radiograph selection currently used assessment destructive diseases. Opinions recorded advantages disadvantages most frequently views.A 100% response rate was achieved. All panoramic specific periapical radiographs as one their regimes disease. Fifty-three per cent respondents took selected radiographs....
ABSTRACTABSTRACTSerum anti-citrullinated protein antibodies (ACPAs), present in 70% of people with rheumatoid arthritis (RA), can be detected ≤10years before the onset clinical disease. RA and periodontitis are epidemiologically associated we have reported a high incidence who ACPA+ at risk RA. Periodontal bacteria may contribute by multiple routes to generation RA-autoantibodies. This study aims characterise subgingival microbiomes from health individuals with/without RA.Forty-five no...
Diabetes and periodontal disease are non-communicable chronic diseases that have a bi-directional relationship. The European Federation of Periodontology International recommend patients with diabetes should be screened for referred to dental professional where appropriate. This study investigated the awareness among Paediatric Care Teams across England Wales as risk factor disease. enquired practices, training, confidence health care professionals in relation A semi-structured online...