A5054100342- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
University of Nebraska Medical Center
2022-2023
Bone metastatic disease of prostate cancer (PCa) is incurable and progression in bone largely dictated by tumor-stromal interactions the microenvironment. We showed previously that neutrophils initially inhibit PCa growth yet becomes resistant to neutrophil response. Further, isolated from tumor-bone lost their ability suppress tumor through unknown mechanisms. With this study, our goal was define impact on function throughout determine potential as predictive biomarkers disease. Using...
The placement of the distal catheter a ventriculoperitoneal shunt (VPS) can be challenging in patients with large body habitus. Given complications associated shunts and known infection risk obese patients, new techniques for VPS that bypass abdominal fat must sought. By avoiding fat, decreased may possible.
Abstract Prostate Cancer (PCa) bone metastases are associated with spinal cord compression, fracture, pain and death. Despite advances in the medical therapy for localized disease, metastatic disease is incurable osseous progression largely dictated by tumor-stromal interactions microenvironment. We showed previously that tumor neutrophils tumoricidal to PCa but lose their cytotoxic potential as progresses. However, there have been no studies date clinically define characterize throughout...