A5061438220- Liver Disease Diagnosis and Treatment
- Inflammasome and immune disorders
- Peroxisome Proliferator-Activated Receptors
- Liver Disease and Transplantation
- Metabolism, Diabetes, and Cancer
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Macrophage Migration Inhibitory Factor
Case Western Reserve University
2013-2016
University School
2013-2015
Alcoholic liver disease (ALD) is characterized by increased hepatic lipid accumulation (steatosis) and inflammation with expression of proinflammatory cytokines. Two these cytokines, interleukin-1 β (IL-1 ) IL-18, require activation caspase-1 via members the NOD-like receptor (NLR) family. These NLRs form an inflammasome that activated pathogens signals released through local tissue injury or death. NLR family pyrin domain containing 3 (Nlrp3) CARD protein 4 (Nlrc4) have been studied...
The peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors is central to the pathophysiology and treatment metabolic disease through receptors' ability regulate expression genes involved in glucose homeostasis, adipogenesis, lipid metabolism. However, mechanism by which PPAR regulated remains incompletely understood. We generated a transgenic mouse strain (ZFP-TG) that overexpressed Zfp407 primarily muscle heart. Transcriptome analysis RNA-Seq identified 1,300...
TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence bacterial components, activating inflammatory cytokines to facilitate clearance pathogens and infected cells. We hypothesized that low-grade constitutive activation may lead induced hepatocyte proliferation prevent fibrosis. gene contains two single nucleotide polymorphisms (SNPs), one located within promoter contained exon 5. These SNPs...