A5070871304- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Shoulder Injury and Treatment
- Cardiovascular Disease and Adiposity
- Anesthesia and Pain Management
- Cardiovascular Function and Risk Factors
- Medical Imaging and Analysis
- Spinal Fractures and Fixation Techniques
- Inflammation biomarkers and pathways
- Bone health and osteoporosis research
- Venous Thromboembolism Diagnosis and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Neurological Disease Mechanisms and Treatments
- Neuroblastoma Research and Treatments
- Cardiovascular Effects of Exercise
- Cardiac Imaging and Diagnostics
- Soft tissue tumor case studies
- Neurofibromatosis and Schwannoma Cases
- Regulation of Appetite and Obesity
- Cervical and Thoracic Myelopathy
- Alzheimer's disease research and treatments
- Acute Ischemic Stroke Management
Kuopio University Hospital
2014-2025
University of Eastern Finland
2019
Abstract Biallelic loss-of-function variants in TYROBP and TREM2 cause autosomal recessive presenile dementia with bone cysts known as Nasu-Hakola disease (NHD, alternatively polycystic lipomembranous osteodysplasia sclerosing leukoencephalopathy, PLOSL). Some other contribute to the risk of Alzheimer’s (AD) frontotemporal dementia, while deleterious are globally extremely rare their role neurodegenerative diseases remains unclear. The population history Finns has favored enrichment founder...
Abstract Biallelic loss-of-function variants in TYROBP and TREM2 cause autosomal recessive presenile dementia with bone cysts known as Nasu-Hakola disease (NHD, alternatively polycystic lipomembranous osteodysplasia sclerosing leukoencephalopathy, PLOSL). Some other contribute to the risk of Alzheimer’s (AD) frontotemporal dementia, while deleterious are globally extremely rare their role neurodegenerative diseases remains unclear. The population history Finns has favored enrichment founder...
Controlled radiological study.To investigate noninvasively in vivo spinal cord displacement the vertebral canal during passive straight leg raise (SLR) asymptomatic subjects. The basic assumption is that follows L5 and S1 nerve roots by similar magnitude direction (principle of linear dependence).It generally accepted SLR produces some caudal movement mainly roots, but this still a matter debate.Sixteen volunteers were scanned with 1.5-T magnetic resonance scanner (Siemens Avanto, Erlangen,...
Central obesity (CO), characterized by an increased waist circumference increases the risk of cardiovascular disease (CVD) and morbidity, yet underlying mechanisms are not fully understood. CO is often associated with general obesity, hypertension, abnormal glucose tolerance, confounding independent contribution to CVD. We investigated relationship (without disorders) left ventricular (LV) characteristics intrathoracic adipose tissue (IAT) cardiac magnetic resonance. LV characteristics,...
Controlled radiological study.Ascertain if a difference exists in the mechanical effects on cord between unilateral and bilateral straight leg raise (SLR) to verify whether effect spinal may be cumulative two.To authors' knowledge these are first data noninvasive, vivo, normative measurement of displacement with SLR test.Sixteen asymptomatic volunteers were scanned 1.5-T magnetic resonance scanner (Siemens Avanto, Erlangen, Germany) using T2-weighted turbo spin-echo fat-saturation sequence....
Purpose The etiology of an ischemic stroke remains undetermined in 20–35% cases and many patients do not have any the conventional risk factors. Increased visceral adipose tissue (VAT) is a suggested new factor for both carotid artery atherosclerosis (CAA) atrial fibrillation (AF), but its role remaining population unknown. We assessed amount VAT with embolic source (ESUS) after excluding major-risk cardioembolic sources, occlusive atherosclerosis, lacunar stroke. Methods Altogether 58 (mean...
Study Design. Controlled radiological study. Objective. To explore whether impairment of neural excursion during the straight leg raise test occurs in patients with sciatic symptoms secondary to lumbar intervertebral disc herniation (LIDH). Summary Background Data. Earlier studies have shown that (SLR) asymptomatic volunteers tensile forces are consistently transmitted throughout system and thoracolumbar spinal cord slides distally. Methods. Fifteen due subacute LIDH were studied a 1.5 T...
The purpose of this investigation was to provide a full set normal data describing neural biomechanics within the vertebral canal in all three planes with unilateral and bilateral SLR tests allow for clinical comparison cases. This is done following notion that, due continuum, tensile forces are transmitted through lumbosacral nerve roots dura conus medullaris (linear dependency principle). In controlled radiologic study 10 asymptomatic volunteers were scanned 1.5T magnetic resonance scanner...
Study Design. A controlled radiologic follow-up study. Objective. The aim of this study was to ascertain whether changes in cord excursion with straight leg raise test (SLR) at 1.5-year time accompany clinical symptoms. Summary Background Data. Lumbar intervertebral disc herniation (LIDH) is known be a key cause sciatica. Previously, we found that significant limitation neural displacement (66.6%) evident the SLR on symptomatic side patients subacute single level posterolateral LIDH....
In Brief Study Design. Controlled radiological study. Objective. Verify (1) whether conus medullaris displacement varies with the range of hip flexion and (2) acquired data support “principle linear dependence.” Summary Background Data. We have previously quantified normal unilateral bilateral straight leg raise (SLR) described However, we since effected methodological advances that produced surpass previous studies. Methods. Ten asymptomatic volunteers were scanned a 1.5-T magnetic...
Normal displacement of the conus medullaris with unilateral and bilateral SLR has been quantified "principle linear dependence" described.Explore whether previously recorded movements SLRs are i) primarily due to transmission tensile forces transmitted through neural tissues during or ii) result reciprocal between vertebrae nerves.Controlled radiologic study.Ten asymptomatic volunteers were scanned a 1.5T magnetic resonance (MR) scanner using T2 weighted spc 3D scanning sequences device that...
Inflammatory rhabdomyoblastic tumors are relatively recently recognized soft tissue with a low malignant potential. Here, we present case of concurrent inflammatory tumor (IRMT), adrenal pheochromocytoma, and pulmonary hamartoma in patient neurofibromatosis type 1 (NF1). To our knowledge, this is the first time that constellation has been described literature.