A5075251017- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- COVID-19 and Mental Health
- Delphi Technique in Research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Sleep and related disorders
- COVID-19 Clinical Research Studies
- Infections and bacterial resistance
- Machine Fault Diagnosis Techniques
- Public Health and Nutrition
- Pediatric health and respiratory diseases
- Obesity and Health Practices
- Chronic Disease Management Strategies
- Fault Detection and Control Systems
- Engineering Diagnostics and Reliability
- COVID-19 and healthcare impacts
- Family and Patient Care in Intensive Care Units
- Family Caregiving in Mental Illness
- Respiratory Support and Mechanisms
- Pharmacology and Obesity Treatment
- IL-33, ST2, and ILC Pathways
- Neonatal Health and Biochemistry
- Optimism, Hope, and Well-being
University of Glasgow
2017-2024
NHS Lanarkshire
2024
Glasgow Royal Infirmary
2020-2023
NHS Greater Glasgow and Clyde
2021-2023
University of the West of Scotland
2023
Phoenix Children's Hospital
2023
University of Arizona
2023
Gartnavel General Hospital
2017-2018
Queen Elizabeth University Hospital
2016-2017
BackgroundFrom early in the COVID-19 pandemic, evidence suggested a role for cytokine dysregulation and complement activation severe disease. In TACTIC-R trial, we evaluated efficacy safety of baricitinib, an inhibitor Janus kinase 1 (JAK1) JAK2, ravulizumab, monoclonal C5 activation, as adjunct to standard care treatment adult patients hospitalised with COVID-19.MethodsTACTIC-R was phase 4, randomised, parallel-arm, open-label platform trial that undertaken UK urgent public health...
Obesity is often associated with uncontrolled, difficult-to-treat asthma and increased morbidity mortality. Previous studies suggest that weight loss may improve outcomes, but heterogenous populations studied unclear consensus on the optimal method of management. The Counterweight-Plus Programme (CWP) for management an evidence-based, dietitian-led total diet replacement (TDR) program.
There are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate psychosocial and physical consequences COVID-19 for patients.We conducted a multicentre observational cohort study; between 3 7 months posthospital discharge, patients who had been admitted critical care due were invited an established recovery service. Standardised questionnaires concerning emotional, social recovery, including information on employment, completed by patients. Using propensity...
Post-COVID-19 syndromes have associated with female sex, but the pathophysiological basis is uncertain.There are sex differences in myocardial inflammation identified using cardiac magnetic resonance (CMR) post-COVID-19 patients, and patient reported health outcomes following COVID-19 infection.This prospective study investigated time-course of multiorgan injury survivors during convalescence.Clinical information, blood biomarkers, outcome measures were prospectively acquired at enrolment...
The present study investigated the use of ensemble empirical mode decomposition (EEMD) based residual signals for condition monitoring and fault diagnosis in bearings. acquired were decomposed using EEMD technique to obtain intrinsic functions (IMFs). For further processing sensitive IMFs selected on basis their similarity index with original signal. signal is then obtained by subtracting ineffective from effective IMFs. After that five statistical features (namely: Root mean square value...
Type 2 (T2) inflammation offers a therapeutic target for biologics. Previous trials suggest obesity influences T2-biomarker levels in asthma, though have not accounted key variables, e.g. inhaled (ICS)/oral corticosteroid (OCS) use. We hypothesized that body mass index (BMI) would affect levels, after adjusting covariates.A retrospective analysis of data from two recent local 153 participants with asthma (102 difficult-to-treat, 51 mild). Measurements included BMI, fractional exhaled nitric...
The United Kingdom National Review of Asthma Deaths (NRAD) recommends that patients who require ≥3 courses oral corticosteroids (OCS) for exacerbations in the past year or those on British Thoracic Society (BTS) Step 4/5 treatment must be referred to a specialist asthma service. aim study was identify proportion primary care fulfil NRAD criteria referral and factors associated with frequent exacerbations. A total 2639 adult from 10 practices Glasgow, UK were retrospectively studied between...
Obesity-associated asthma results in increased morbidity and mortality. We report 1-year outcomes with a weight management regimen, the Counterweight-Plus Programme (CWP), compared usual care (UC) single-center, randomized controlled trial patients difficult-to-treat obesity.
Difficult-to-control asthma associated with elevated body mass index (BMI) is challenging limited treatment options. The effects of pulmonary rehabilitation (PR) in this population are uncertain.
Here we report an unusual case of ruptured lung abscess, complicated by both a persistent air leak and empyema necessitans. This combination problems, in patient with significant co-morbidities presented major diagnostic difficulties and challenging pleural intervention issues . The based discussion presented also highlights number important learning points that can be generalised to the assessment and management patients severe pleuro-pulmonary infections, including minority associated...
Management of difficult-to-treat asthma is particularly challenging in people with elevated body mass index (BMI). Our randomised controlled trial pulmonary rehabilitation (PR) showed improved outcomes at 8 weeks. Here we assess immediate and one-year effects asthma-tailored PR participants BMI ≥25 kg/m
<h3>Introduction</h3> We delivered a one-year weight management programme (Counterweight Plus, CWP) in participants with difficult-to-treat asthma and obesity single-centre randomised controlled trial resulting median loss of 14kg improvements Asthma Quality Life Questionnaire (AQLQ) exacerbation frequency at one-year. CWP was dietitian-supported total diet replacement lasting one year total. Following this, were invited back after intervention completion the two-year mark for further...
<h3>Introduction</h3> Obesity-associated asthma is a difficult-to-treat phenotype linked with poorer disease control, reduced quality of life and increased morbidity mortality. This coupled type 2 (T2)-high inflammation may respond to currently available biologic treatments. Previous studies have shown reduction in fractional exhaled nitric oxide (FeNO) increasing body mass index (BMI) however, our knowledge, no this effect when adjusted for confounding variables such as corticosteroid use....
<h3>Background</h3> One of the key recommendations NRAD<sup>1</sup> is that patients who require 2 courses or more oral corticosteroids (OCS) for asthma in last 12 months should be referred to a specialist service. This may put undue pressure on secondary care services as number such unknown. <h3>Aims</h3> To identify with recurrent exacerbations would merit referral care, and study biopsychosocial factors associated frequent exacerbations. <h3>Methods</h3> Data were retrospectively...
We report a case of nine-month-old twins who presented with bright green diarrhea along progressively worsening jaundice over one week. On initial evaluation, they were found to have significantly elevated liver enzymes, bilirubin, and alkaline phosphatase levels but without signs failure. They tested for multiple causes injury including autoimmune infectious etiologies, which negative as well. Both incidentally be positive COVID-19 on testing per hospital protocol did not any respiratory...
<h3>Introduction</h3> We previously reported improved Asthma Control Questionnaire (ACQ6) and Quality of Life (AQLQ) scores with weight-loss after 16 weeks the Counterweight-Plus weight management programme (CWP) compared to usual care (UC) in a single-centre, randomised, controlled trial patients difficult-to-treat asthma obesity.<sup>1</sup> Here we report one-year outcomes from this trial. <h3>Methods</h3> randomised (1:1 CWP:UC) adults body mass index (BMI) ≥30 kg/m<sup>2</sup>. CWP...
<b>Background:</b> Frequent asthma exacerbations are associated with high morbidity and the death rates in remain unacceptably across Europe. NRAD<sup>1</sup> recommends that patients who require >2 courses of oral corticosteroids (OCS) for a year or those on British Thoracic Society Step 4/5 should be referred to specialist service. <b>Aims:</b> To identify would merit referral service biopsychosocial factors frequent exacerbations. <b>Methods:</b> 2639 adult from 10 primary care...
Coronavirus Disease 19 (COVID-19) can present as an Adult Respiratory Distress Syndrome (ARDS)-like pneumonia. Continuous Positive Airway Pressure (CPAP) for ARDS is usually delivered in Intensive Care Units (ICU). ICU beds led to Glasgow Royal Infirmary developing a COVID-19 High Dependency Unit (C-HDU) where domiciliary non-invasive ventilators (NIV) (Lumis 150, Resmed) with supplementary oxygen CPAP respiratory failure due We review the feasibility and efficacy of delivering outside...
<h3>Introduction</h3> Obesity is often linked with difficult-to-treat asthma and increased morbidity mortality. Asthma obesity are on the rise posing a challenge to specialists. The Counterweight-Plus weight management programme (CWP) dietitian-supported, structured diet an evidence base in type 2 diabetes (Lean <i>et al</i>. Lancet, Feb 2018; doi: 10.1016/S0140-6736(17)33102–1). Its effects have not been assessed patients obesity. <h3>Objective</h3> To evaluate of CWP against usual care...
<b>Introduction:</b> Uncontrolled asthma can cause sleep disruption. Accelerometer devices have been validated against polysomnography to measure parameters. No studies used accelerometers compare outcomes between severity groups. <b>Aim:</b> We hypothesised that parameters may vary mild (MA) and difficult-to-treat (DTA) performed a post-hoc analysis from two recent in-house trials (ID NCT03630432, NCT03858608). <b>Methods:</b> 7-day data 133 participants with MA DTA were collected using...
<b>Introduction:</b> Obesity is linked with uncontrolled, severe asthma. The Counterweight-Plus weight management programme (CWP) an evidence-based, dietician-led, structured diet programme. <b>Aim:</b> To evaluate the effects of CWP versus usual care (UC) on asthma-related outcomes in a randomised, controlled trial uncontrolled asthma associated obesity. <b>Methods:</b> We randomised (1:1 CWP:UC) adults and body mass index (BMI) ≥30kg/m<sup>2</sup>. CWP: 12-week total replacement phase...
<h3>Background</h3> Difficult-to-control asthma associated with elevated body mass index (BMI) represents a significant challenge, limited treatment options. The effects of pulmonary rehabilitation (PR) in this population are uncertain. <h3>Methods</h3> This randomised controlled trial compared an asthma-tailored PR programme to usual care (UC) participants uncontrolled and BMI ≥25 kg/m<sup>2</sup>. comprised hour education exercise each week for eight weeks. Primary outcome was difference...