A5090054852- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Drug Transport and Resistance Mechanisms
- Genomic variations and chromosomal abnormalities
- DNA Repair Mechanisms
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Pharmacogenetics and Drug Metabolism
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Cancer therapeutics and mechanisms
- Pharmacological Effects and Toxicity Studies
- Epigenetics and DNA Methylation
- Glutathione Transferases and Polymorphisms
- HER2/EGFR in Cancer Research
- ATP Synthase and ATPases Research
- Melanoma and MAPK Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Neuropeptides and Animal Physiology
- Hedgehog Signaling Pathway Studies
- Breast Lesions and Carcinomas
- Cutaneous Melanoma Detection and Management
Universidad Complutense de Madrid
2024-2025
The Maria Sklodowska-Curie National Research Institute of Oncology
2007-2024
National Institute of Oncology
2022
Centrum Onkologii
2014-2018
International Institute for Molecular Oncology
2018
// Karolina Tecza 1 , Jolanta Pamula-Pilat Joanna Lanuszewska Dorota Butkiewicz and Ewa Grzybowska Center for Translational Research Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Institute Oncology, Gliwice, Poland Correspondence to: Grzybowska, email: ewagrzybowska@yahoo.com Keywords: breast cancer; FAC; chemotherapy; polymorphism; treatment toxicity Received: October 06, 2017 Accepted: January 02, 2018 Published: 10, ABSTRACT The differences in patients' response to...
Abstract Several neuropeptides present in bone tissues, produced by nerve fibers and cells, have been reported to play a role regulating the fine‐tuning of osteoblast osteoclast functions maintain homeostasis. This study aims characterize influence neuropeptide vasoactive intestinal peptide (VIP) on differentiation process human mesenchymal stem cells (MSCs) into osteoblasts their anabolic function. We describe mRNA protein expression profile VIP its receptors MSCs as they differentiate...
The purpose of our study was to establish the frequency and distribution four most common BRCA1 mutations in Polish general population a series breast cancer patients. Analysis 5382insC (c.5266dupC), 300T >G (p.181T >G), 185delAG (c.68_69delAG) 3819del5 (c.3700_3704del5) gene were performed on group respectively 16,849, 13,462, 12,485 3923 anonymous samples collected at birth seven provinces. patient consisted 1845 consecutive female cases. frequent mutation found 29 out 16,849 (0.17%). 11...
Ovarian malignancies are often diagnosed in advanced stage and at the same time resistance to treatment, both intrinsic developed during is sometimes observed. These facts underscore need for new markers of ovarian cancer risk, as well treatment effectiveness.In this study we genotyped 225 patients, 64 breast patients 348 healthy controls. In total, 12 polymorphic variants 2 deletions PGR, ABCB1, ABCG2, GSTT1, GSTM1, GSTP1, ATM, TP53 ATP7B genes were analyzed using ASA-PCR, RFLP-PCR,...
<title>Abstract</title> Current therapies for osteoarthritis (OA) focus on symptom management, rather than halting disease progression. Vasoactive intestinal peptide (VIP) has shown promising effects in musculoskeletal diseases, preserving joint integrity and modulating inflammation. This study investigates the potential of VIP to promote chondrogenic differentiation human bone marrow mesenchymal stem cells (BM-hMSC), while inflammatory cartilage extracellular matrix (ECM)-degrading...
Clinical resistance to chemotherapy is one of the major problems in breast cancer treatment. In this study we analyzed possible impact 22 polymorphic variants on treatment response 324 patients. Selected genes were involved FAC drugs transport (ABCB1, ABCC2, ABCG2, SLC22A16), metabolism (CYP1B1, CYP2C19, GSTT1, GSTM1, GSTP1, TYMS, MTHFR, DPYD), drug-induced damage repair (ERCC1, ERCC2, XRCC1) and regulation DNA cell cycle control (ATM, TP53).Apart from preexisting metastases three...
Abstract The study describes a relationship between the 3′UTR variants, clinicopathological parameters and response to chemotherapy. We analyzed 33 germline polymorphisms in 3′UTRs of ADME genes 305 breast cancer women treated with FAC regime. Clinical endpoints this were: overall survival (OS), progression-free (PFS), recurrence-free (RFS) defined as treatment failure-free (TFFS). shortened OS was connected presence NR1/2 rs3732359 AA, SLC22A16 rs7756222 CC, well rs9487402 allele G clinical...
<b><i>Objective:</i></b> The suppressor gene<i> CHEK2</i> encodes a cell cycle checkpoint kinase, involved in regulation, apoptosis and response to DNA damage. aim of this study was analyze the differences between <i>CHEK2 </i>mutation carriers (<i>CHEK2</i>*1100delC/I157T) noncarriers with respect clinicopathological factors. <b><i>Methods:</i></b> We reviewed medical records 100 early breast cancer patients...
We studied the associations between 3'UTR genetic variants in ADME genes, clinical factors, and risk of breast cancer chemotherapy toxicity. Those factors were tested relation to seven symptoms belonging myelotoxicity (anemia, leukopenia, neutropenia), gastrointestinal side effects (vomiting, nausea), nephrotoxicity, hepatotoxicity, occurring overall, early, or recurrent settings. The cumulative overall anemia was connected with
Abstract Background Copy number polymorphisms caused by genomic rearrangements like deletions, make a significant contribution to the differences between two individuals and may add disease predisposition. Therefore, genotyping of such deletion in case-control studies could give important insights into risk associations. Results We mapped breakpoints developed fluorescent fragment analysis for disrupting TRY6 gene exemplify quick cheap approach structural variants. showed that is larger than...
Apart from drug resistance, the patients' oversensitivity to chemotherapy is one of most serious problems in cancer treatment. Cytotoxic drugs aim intensively proliferating cells, but unfortunately these also destroy other cells and tissues with high proliferation rates, such as epithelia gastro-intestinal track bone marrow skin, leading chemotherapy-related toxicities. Furthermore, adverse reactions are observed relatively slow organs involved systemic detoxification clearance, i.e. liver...
<b>Introduction</b>: The 3020insC mutation of <I>NOD2</I> predisposes to many types common cancers, e.g. breast cancer. In this report we compare carriers with non-carriers in a similar age range at diagnosis according clinicopathological factors and survival cancer patients from the Silesia region Poland. <br /> <b>Material methods</b>: We reviewed medical records 72 early patients, who were diagnosed treated COI Gliwice. Genetic diagnostics was...
The unique oncogenic duo of BRAF and TERT promoter ( p) variants was demonstrated to be associated with aggressiveness poor prognosis in several different cancer types, including melanoma thyroid cancer. It has been shown that the coexistence p a significantly more substantial impact on clinical outcomes than presence mutated or alone. At same time, co-occurrence may also Achilles Heel cells context targeted therapies' effectiveness. This paper aims summarize data from tumors which...
Human reaction to drugs, including chemotherapeutics, is an extremely complex process, with many enzymes of different metabolic and signal transduction pathways involved. Despite the knowledge already gathered, exact mechanisms responsible for individual patients’ responses chemotherapy adverse reactions, are still not clear. Cellular transport detoxification systems evolved as natural protection against xeniobiotics they process substrates that belong diverse chemical classes. There...
Single nucleotide polymorphisms modulate the risk of developing ovarian cancer during lifetime. In this study we analyzed 12 polymorphic variants and 2 deletions in PGR, ABCB1, ABCG2, GSTT1, GSTM1, GSTP1, ATM, TP53 ATP7B genes. Ten genetic modifications were significantly associated with carcinoma at least one groups under study. PGR gene polymorphisms’ impact on was specific only for group BRCA1 mutation carriers, which proves difference modulation between sporadic hereditary malignancies,...
Copper is the trace element essential for proper functioning of cells because its role as cofactor many crucial enzymes, such cytochrome c oxidase, superoxide dismutase and lysyl oxidase. Cellular transport system ensures exact distribution copper throughout body consequently malfunction could lead to serious medical conditions, Menkes Wilson disease. Apart from this used move platinum derivates through cell body- including widely chemotherapeutic drug cisplatin. It therefore believed that...
Targeted therapy of non-small cell lung cancer necessitates fast and reliable molecular evaluation tissue/cytologic samples within the routine diagnostic process. Here we present dynamic development EGFR mutation screening program for NSCLC patients in Poland previous 4 years. In total, 177 were analysed mutations 2011 (11,3% positive), 915 (8,7%) 2012, 1843 (9,9%, 1,2% unsuitable diagnostics) 2013, 3405 (10,6%, 1,7% 2014. Most adenocarcinomas (82,1% 93,2% 2014), number NOS materials fell...