A5002029548- Trypanosoma species research and implications
- Malaria Research and Control
- Research on Leishmaniasis Studies
- Lipid Membrane Structure and Behavior
- Lipoproteins and Cardiovascular Health
- Diagnosis and treatment of tuberculosis
- Computational Drug Discovery Methods
- Online and Blended Learning
- Gastrointestinal disorders and treatments
- Complementary and Alternative Medicine Studies
- COVID-19 Prevention and Impact
- Healthcare Policy and Management
- Varied Academic Research Topics
- Primary Care and Health Outcomes
- Lysosomal Storage Disorders Research
- Amoebic Infections and Treatments
- Diverticular Disease and Complications
- Innovative Teaching Methods
- Experimental Learning in Engineering
- Insect Utilization and Effects
- Lung Cancer Research Studies
- Blockchain Technology Applications and Security
- Facial Nerve Paralysis Treatment and Research
- Pediatric Urology and Nephrology Studies
- Corporate Insolvency and Governance
Harvard University
2018-2023
Annapurna Neurological Institute and Allied Sciences
2023
GD Goenka University
2020-2022
Northwestern University
2014-2022
Torbay and South Devon NHS Foundation Trust
2022
University of Jammu
2020-2021
LNM Institute of Information Technology
2021
Torbay Hospital
2016-2018
Wellesley College
2016
Govind Ballabh Pant Hospital
2013
Coronavirus Disease (COVID-19) outbreak poses serious concerns to global education systems. Efforts contain COVID-19 prompted unscheduled closure of schools in more than 100 countries worldwide. school closures left over one billion learners out school. The study investigates the impact on education. Data were collected through structured questionnaires administered 200 respondents that consist teachers, students, parents, and policy makers selected from different countries. data analyzed...
Drug resistance is an obstacle to global malaria control, as evidenced by the recent emergence and rapid spread of delayed artemisinin (ART) clearance mutant forms PfKelch13 protein in Southeast Asia. Identifying genetic determinants ART African-derived parasites important for surveillance understanding mechanism resistance. In this study, we carried out long-term vitro selection two recently isolated West African (from Pikine Thiès, Senegal) with increasing concentrations dihydroartemisinin...
The concept of blockchain, widely known as virtual currencies, saw a massive surge in popularity recent times. As far the security blockchain is concerned, consensus algorithms play vital role blockchain. Research has been done separately, or comparisons between few them have presented previously. In this paper, we discussed used protocols covered paper include PoW (Proof Work), PoS Stake), DPoS (Delegated Proof PoET Elapsed Time), PBFT (Practical Byzantine Fault Tolerance), and PoA...
Malaria continues to impose a significant health burden in the continent of Africa with 213 million cases 2018 alone, representing 93% worldwide. Because high transmission malaria within continent, selection pressures develop drug resistance African parasites are distinct compared rest world. In light spread artemisinin conferred by C580Y mutation Pf Kelch13 propeller domain Southeast Asia, and its independent emergence South America, it is important study genetic determinants context using...
Background In vitro haemolysis is a common occurrence in clinical laboratories and causes spurious increase potassium. the past, was sought by visual inspection but now commonly detected automated measurement of haemolytic index (HI). This study compared detection adult neonatal samples HI verified that single equation appropriate to correct for potassium both haemolysed samples. Methods Laboratory staff inspected their observations were with measured HI. The concentrations indices 613 523...
Sphingolipids are important constituents of cell membranes and also serve as mediators signaling recognition. Sphingolipid metabolites such sphingosine-1-phosphate ceramide regulate cascades involved in proliferation differentiation, autophagy, inflammation, apoptosis. Little is known about how sphingolipids their function single-celled eukaryotes. In the present study, we investigated role sphingosine kinase (SPHK) biology protozoan parasite Trypanosoma brucei, agent African sleeping...
Organisms develop and evolve in a modular fashion, but how individual modules interact with the environment remains poorly understood. Phenotypically plastic traits are often under selection, studies needed to address respond fashion. In this study, tissue-specific plasticity of melanic spots was examined large milkweed bug, Oncopeltus fasciatus.Although size abdominal bands varied according rearing temperatures, wing were more robust. To explore regulation pigmentation plasticity, candidate...
Abstract Cilia play important roles in cell signaling, facilitated by the unique lipid environment of a ciliary membrane containing high concentrations sterol-rich rafts. The African trypanosome Trypanosoma brucei is single-celled eukaryote with single cilium/flagellum. We tested whether flagellar sterol enrichment results from selective partitioning specific species or general all sterols. While sterols are enriched flagellum, cholesterol especially enriched. T. cycles between its mammalian...
Artemisinin (ART) combination therapies have been critical in reducing malaria morbidity and mortality, but these important drugs are threatened by growing resistance associated with mutations
Cardiac toxicity resulting in long-term complications are recognised side effect of anthracycline-based chemotherapy used the treatment breast cancer. Current management modality involves measurement left ventricular ejection fraction which has inherent limitations due to its dependence on haemodynamic conditions, and inability detect subclinical changes systolic function. This study aimed evaluate concentration cardiac biomarkers present serum as indicators cancer patients undergoing...
Lipid rafts are liquid-ordered membrane microdomains that form by preferential association of 3-β-hydroxysterols, sphingolipids and raft-associated proteins often having acyl modifications. We isolated lipid the protozoan parasite Trypanosoma brucei determined protein composition in cell. This analysis revealed a striking enrichment flagellar several putative signaling raft proteome. Calpains intraflagellar transport proteins, particular, were found to be abundant These findings provide...
Sir, It is estimated that there are approximately 340 parasite species capable of infecting humans, with the majority infected population residing in developing regions world.[1] The immune system, through local and systemic responses has an important role to play modifying establishment infection, controlling disease, limiting severity clearance parasite. Isospora belli a coccidian, unicellular protozoan resides gastrointestinal tract humans. usually causes non-bloody diarrhea tropical...
Annular pancreas (AP) is a rare congenital abnormality in which the ventral portion of fails to rotate with duodenum during embryological development, thus causing remain partially or fully enveloped around duodenum. The actual incidence AP unknown, as many cases are asymptomatic and undiagnosed. Adults may present variety symptoms suggestive gastric outlet obstruction, gastrointestinal bleeding, pancreatitis, biliary obstruction. Surgery continues diagnostic “gold standard” for AP, but...
Dynamic post-translational modifications allow the rapid, specific, and tunable regulation of protein functions in eukaryotic cells. S-acylation is only reversible lipid modification proteins, which a fatty acid, usually palmitate, covalently attached to cysteine residue by zDHHC palmitoyl acyltransferase enzyme. Depalmitoylation required for acylation homeostasis catalyzed an enzyme from alpha/beta hydrolase family proteins acyl-protein thioesterase (APT1). The responsible depalmitoylation...