A5101704307- Plant biochemistry and biosynthesis
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Protein Interaction Studies and Fluorescence Analysis
- Cholesterol and Lipid Metabolism
- Essential Oils and Antimicrobial Activity
- Antioxidant Activity and Oxidative Stress
- Metabolomics and Mass Spectrometry Studies
- Metal complexes synthesis and properties
- Free Radicals and Antioxidants
- Cannabis and Cannabinoid Research
- Phytochemicals and Antioxidant Activities
- Gut microbiota and health
- Lipid metabolism and biosynthesis
- Paraquat toxicity studies and treatments
- Plant-based Medicinal Research
- Liver Disease Diagnosis and Treatment
- Synthesis and Characterization of Heterocyclic Compounds
- Molecular Biology Techniques and Applications
- Traditional Chinese Medicine Analysis
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant-Microbe Interactions and Immunity
- Analytical Chemistry and Chromatography
- Mycorrhizal Fungi and Plant Interactions
- Natural product bioactivities and synthesis
Hunan University of Traditional Chinese Medicine
2025
Nanjing University of Chinese Medicine
2014-2022
This study measured the impact of alisol B 23‐acetate and A 24‐acetate, main active ingredients traditional Chinese medicine Alismatis rhizoma, on total cholesterol (TC), triglyceride (TG), high density lipoprotein‐cholesterol (HDL‐C), low (LDL‐C) levels hyperlipidemic mice. The binding 24‐acetate to key enzyme involved in metabolism TC, 3‐hydroxy‐3‐methylglutary‐coenzyme (HMG‐CoA) reductase, was studied using reagent kit method western blotting technique combined with a molecular simulation...
Objectives To explore the mechanism underlying effect of Fructus Akebiae (FAE) against hepatic fibrosis in mice through combined network pharmacology, liver metabolomics, and 16S rDNA analyses gut microbiota. Methods In this study, we randomly divided into control, model, FAE high-dose, medium-dose, low-dose groups to analyze pathological changes levels α -SMA, collagen 1, Nuclear Factor Kappa B (NF- κ B), Toll Like Receptor 4 (TLR4). The microbiota was analyzed sequencing analysis...
Abstract Protostane triterpenes, which are found in Alisma orientale , tetracyclic triterpenes with distinctive pharmacological activities. The natural distribution of protostane is limited mainly to members the botanical family Alismataceae. Squalene epoxidase (SE) key rate-limiting enzyme triterpene biosynthesis. In this study, we report characterization two SEs from A. . AoSE1 and AoSE2 were expressed as fusion proteins E. coli purified used functional research. vitro assays showed that...
We prepared extracts of Alisma orientalis from Sichuan and Fujian Province, China. Based on the ratio alisol B 23-acetate (23B) to A 24-acetate (24A) in two extracts, we mixtures 24A 23B (24A:23B = 1:3 or 1:10). The antitumor molecular mechanism monomers 23B, effective components different habitats were studied. MTT assay suggested that difference activity was correlated 23B. multi-spectroscopic analysis components, interacted with c-myc DNA a partial intercalation manner. binding strength...
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This study investigated the anti-hepatoma molecular mechanism of Alisol G, which is an effective component Chinese medicine Alisma orientalis, in presence metal ions Cu2+ and Fe3+ based on c-myc DNA. Here, a combination G (Cu2+, Fe3+) to augment efficiencies has been identified by methyl thiazolyl tetrazolium (MTT) assay. Network pharmacology revealed that DNA was potential target with respect its effects. By performing multi-spectroscopic analyses, we showed interaction process static...