A5003295907- Bone health and treatments
- Radiopharmaceutical Chemistry and Applications
- TGF-β signaling in diseases
- Muscle Physiology and Disorders
- Medical Imaging and Pathology Studies
- Cancer Cells and Metastasis
- RNA Research and Splicing
- Bone and Dental Protein Studies
- Genetic Neurodegenerative Diseases
- Medical Imaging Techniques and Applications
- Genetics and Neurodevelopmental Disorders
- Management of metastatic bone disease
- Prostate Cancer Treatment and Research
- Neurogenetic and Muscular Disorders Research
- Cardiomyopathy and Myosin Studies
- Tissue Engineering and Regenerative Medicine
- 3D Shape Modeling and Analysis
- Software Engineering and Design Patterns
- Logic, programming, and type systems
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- bioluminescence and chemiluminescence research
- Research Data Management Practices
- Nanoplatforms for cancer theranostics
- Periodontal Regeneration and Treatments
Leiden University Medical Center
2000-2011
Neurology, Inc
2007
Leiden University
2007
Centre for Human Drug Research
2005
Center for Human Genetics
2004
Radboud University Nijmegen
2003
Radboud University Medical Center
2003
Philips (Netherlands)
1999
Abstract Bone morphogenetic protein 7 (BMP7) counteracts the physiological epithelial-to-mesenchymal transition (EMT), a process that is indicative of epithelial plasticity. Because EMT involved in cancer, we investigated whether BMP7 plays role breast cancer growth and metastasis. In this study, show decreased expression primary significantly associated with formation clinically overt bone metastases patients ≥10 years follow-up. line these clinical observations, inversely related to...
Abstract Facioscapulohumeral muscular dystrophy (FSHD) progressively affects the facial, shoulder, and upper arm muscles is associated with contractions of polymorphic D4Z4 repeat array in 4q35. Recently, we demonstrated that FSHD alleles are hypomethylated at D4Z4. To study potential relationships between hypomethylation both residual size clinical severity, compared severity score methylation unrelated patients. Correcting for age examination improves parameter to define provides further...
Chromosomal rearrangements occur more frequently in subtelomeric domains than other regions of the genome and are often associated with human pathology. To further elucidate plasticity domains, we examined 3.3 kb D4Z4 repeat array on chromosome 4 its homologue 10 208 Dutch blood donors by pulsed field gel electrophoresis. These repeats known to rearrange partial deletions this polymorphic facioscapulohumeral muscular dystrophy (FSHD), an autosomal dominant myopathy. Our results show that...
<b><i>Objective:</i></b> Autosomal dominant facioscapulohumeral muscular dystrophy (FSHD) is associated with a contraction of the D4Z4 repeat array on chromosome 4. So far, homozygosity or compound heterozygosity for FSHD alleles has not been described, and it debated whether absence such subjects because rarity lethality disorder. <b><i>Methods:</i></b> Two unrelated families in which probands are heterozygous two FSHD-sized were studied. Clinical examination, pulsed-field gel...
We consider the problem of real-time animation a cartoon character which is represented by skeleton implicit surface. If character's motions permit constant topology for skin, it possible to reduce computing an approximation surface solve only one scalar equation per point fixed number points; these points define shape triangle mesh with topology. present algorithm, and demonstrate its working in model walking legs.
Supplementary Figure 1 from Bone Morphogenetic Protein 7 in the Development and Treatment of Metastases Breast Cancer
Supplementary Methods and Materials from Bone Morphogenetic Protein 7 in the Development Treatment of Metastases Breast Cancer
<div>Abstract<p>Bone morphogenetic protein 7 (BMP7) counteracts the physiological epithelial-to-mesenchymal transition (EMT), a process that is indicative of epithelial plasticity. Because EMT involved in cancer, we investigated whether BMP7 plays role breast cancer growth and metastasis. In this study, show decreased expression primary significantly associated with formation clinically overt bone metastases patients ≥10 years follow-up. line these clinical observations,...
<div>Abstract<p>Bone morphogenetic protein 7 (BMP7) counteracts the physiological epithelial-to-mesenchymal transition (EMT), a process that is indicative of epithelial plasticity. Because EMT involved in cancer, we investigated whether BMP7 plays role breast cancer growth and metastasis. In this study, show decreased expression primary significantly associated with formation clinically overt bone metastases patients ≥10 years follow-up. line these clinical observations,...
Supplementary Figure 1 from Bone Morphogenetic Protein 7 in the Development and Treatment of Metastases Breast Cancer
Supplementary Methods and Materials from Bone Morphogenetic Protein 7 in the Development Treatment of Metastases Breast Cancer