A5005996885- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cellular Mechanics and Interactions
- Material Dynamics and Properties
- Theoretical and Computational Physics
- Retinoids in leukemia and cellular processes
- Granular flow and fluidized beds
- Micro and Nano Robotics
- Advanced Thermodynamics and Statistical Mechanics
- Force Microscopy Techniques and Applications
- Advanced Materials and Mechanics
- Neutropenia and Cancer Infections
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Microtubule and mitosis dynamics
- Oral microbiology and periodontitis research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lung Cancer Research Studies
- Complex Network Analysis Techniques
- Protein Structure and Dynamics
- Childhood Cancer Survivors' Quality of Life
- Multiple Myeloma Research and Treatments
- Stochastic processes and statistical mechanics
- Rheology and Fluid Dynamics Studies
University of Leeds
2015-2025
Vanderbilt University Medical Center
2002-2024
Exact Sciences (United States)
2022
Lantheus Medical Imaging (United States)
2022
AstraZeneca (Brazil)
2022
Breast Cancer Research Foundation
2022
Vanderbilt-Ingram Cancer Center
2022
GlaxoSmithKline (India)
2022
Gilead Sciences (Canada)
2022
University of North Carolina at Chapel Hill
2020
The myelodysplastic syndromes (MDS) represent a heterogeneous group of clonal hematopoietic disorders characterized by cytopenias, dysplasia in one or more myeloid lineages, and the potential for development acute leukemia. These primarily affect older adults. NCCN Clinical Practice Guidelines Oncology MDS provide recommendations on diagnostic evaluation classification MDS, risk according to established prognostic assessment tools (including new revised International Prognostic Scoring...
OverviewThe myelodysplastic syndromes (MDS) represent myeloid clonal hemopathies with relatively heterogeneous spectrums of presentation.The major clinical problems in these disorders are morbidities caused by cytopenias and the potential for MDS to evolve into acute leukemia (AML).In general population, occur 5 per 100,000 people.However, among individuals older than 70 years, incidence increases between 22 45 further age.Managing is complicated generally advanced age patients (median ages,...
The myelodysplastic syndromes (MDS) comprise a heterogenous group of myeloid disorders with highly variable disease course. Diagnostic criteria to better stratify patients MDS continue evolve, based on morphology, cytogenetics, and the presence cytopenias. More accurate classification will allow for treatment guidance. Treatment encompasses supportive care, anemia, low-intensity therapy, high-intensity therapy. This portion guidelines focuses diagnostic classification, molecular...
The NCCN Guidelines for Myelodysplastic Syndromes (MDS) provide recommendations the evaluation, diagnosis, and management of patients with MDS based on a review clinical evidence that has led to important advances in treatment or yielded new information biologic factors may have prognostic significance MDS. multidisciplinary panel experts meets an annual basis update recommendations. These Insights focus some updates 2022 version Guidelines, which include both lower-risk higher-risk MDS,...
Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various crosslinking and other associated largely determine the (visco)elastic response cells. In this letter we study model system crosslinked, stiff filaments order to explore connection between microstructure under strain macroscopic networks. We find two distinct regimes as function primarily crosslink density filament rigidity: one characterized by affine deformation...
Semiflexible polymers such as filamentous actin (F-actin) play a vital role in the mechanical behavior of cells, yet basic properties cross-linked F-actin networks remain poorly understood. To address this issue, we have performed numerical studies linear response homogeneous and isotropic two-dimensional subject to an applied strain at zero temperature. The elastic moduli are found vanish for network densities rigidity percolation threshold. For higher densities, two regimes observed: one...
PURPOSE Therapy of hairy cell leukemia has markedly improved. Interferon alfa-2a and pentostatin are active agents. The National Cancer Institute organized an intergroup trial to compare these agents prospectively in untreated patients. METHODS Patients were randomized receive either interferon (3 x 10(6) U subcutaneously three times per week) or (4 mg/m2 intravenously every 2 weeks). who did not respond initial treatment crossed over. RESULTS Of 356 patients on study, 313 eligible. Among...
Quantitatively measuring the mechanical properties of soft matter over a wide range length and time scales, especially if sample is as complex typical biological materials, remains challenging. Living cells present further complication because forces are generated within these nonequilibrium materials that can change material properties. We have here developed high-bandwidth techniques for active one- two-particle microrheology to tackle issues. By combining micromanipulation probe particles...
Dynamic networks designed to model the cell cytoskeleton can be reconstituted from filamentous actin, motor protein myosin and a permanent cross-linker. They are driven out of equilibrium when molecular motors active. This gives rise athermal fluctuations that recorded by tracking probe particles dispersed in network. We have here probed such "active gels" using video microrheology. measured full distribution displacements, also known as van Hove correlation function. The dominant influence...
PURPOSE In an effort to improve outcome for children with advanced B-cell malignancies, a treatment plan based on published regimen that consists of four courses fractionated cyclophosphamide (cyclo) given doxorubicin (doxo) and vincristine (VCR) was intensified by alternating sequential high-dose methotrexate (MTX) cytarabine (Ara-C), in conjunction intrathecal (IT) MTX Ara-C. PATIENTS AND METHODS From October 1986 1992, 133 eligible patients were enrolled: 74 (surface...