A5031746725- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Protein purification and stability
- Analytical Chemistry and Chromatography
- Advancements in Transdermal Drug Delivery
- Pharmaceutical studies and practices
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Opinion Dynamics and Social Influence
- Proteins in Food Systems
- Complex Network Analysis Techniques
- Computational Drug Discovery Methods
- Surfactants and Colloidal Systems
- Granular flow and fluidized beds
- Analytical Methods in Pharmaceuticals
- Chemical and Physical Properties in Aqueous Solutions
- Transgenic Plants and Applications
- Diffusion Coefficients in Liquids
- Neonatal Health and Biochemistry
- Cyclone Separators and Fluid Dynamics
- Intramuscular injections and effects
- Innovative Microfluidic and Catalytic Techniques Innovation
- Injection Molding Process and Properties
- Thermodynamic properties of mixtures
- Advanced Battery Materials and Technologies
University of Kansas
2018-2025
Amgen (United States)
2018-2023
Gem Pharmaceuticals (United States)
2015
Shanghai Jiao Tong University
2013-2014
University of Tennessee Health Science Center
2011-2013
National Institutes for Food and Drug Control
2011
Polysorbate 80 (PS80) is widely used in pharmaceutical formulations, and its commercial grades exhibit certain levels of structural heterogeneity. The objective this study was to apply coarse-grained molecular dynamics simulations better understand the effect PS80 heterogeneity on micelle self-assembly, loading hydrophobic small molecules into core, interactions between a protein, bovine serum albumin (BSA). Four representative variants with different head tail structures were studied. Our...
Objective: To mask the bitterness of Chlorpheniramine Maleate via encapsulating drug into Eudragit EPO microparticles, and then incorporate these microparticles orally disintegrating films (ODF) tablets (ODT) for pediatric uses.Methods: Spray drying water-in-oil emulsion was utilized to encapsulate microparticles. Based on an orthogonal experimental design L9 (33), polynomial regression models were developed evaluate correlation between microparticle properties (encapsulation efficiency...
A reliable in vitro system can support and guide the development of subcutaneous (SC) drug products. Although several systems have been developed, they some limitations, which may hinder them from getting more engaged SC product development. This study sought to develop a novel system, namely, Emulator SubCutaneous Absorption Release (ESCAR), better emulate vivo environment predict fate drugs delivery. ESCAR was designed using computer-aided design (CAD) software fabricated three-dimensional...
The purpose of this study is to evaluate the influence sodium iodide, chloride and sulfate on formation efficiency sulfamerazine nanocrystals by wet ball milling.Sulfamerazine was milled using zirconium oxide beads in a solution containing polyvinylpyrrolidone (PVP) salt (iodide, or sulfate). Particle size distributions were evaluated light diffraction before after milling. High-performance liquid chromatography utilized determine amount PVP adsorbed onto surface. Lyophilized further...
Molecular dynamics simulations were employed to investigate the interaction between Fe(III) and an iron-binding site composed of THR259, ASP252, GLU261 on Fc domain IgG1. The goal was provide microscopic mechanistic information for photochemical, iron-dependent site-specific oxidative fragmentation IgG1 at THR259 reported in our previous paper. distance residues interest as well binding pocket size examined both protonated deprotonated THR259. free energy (ΔG) estimated by using umbrella...
This study aimed to investigate the diffusivities of lysozyme (LYS), ovalbumin (OVA), and hyaluronic acid (HA) in buffered solvents using dynamic light scattering (DLS). For protein/solvent HA/solvent binary systems, diffusion coefficients protein or HA were obtained from autocorrelation function (ACF) curve fitting. Whereas, for protein/HA/solvent ternary two eigenvalues mutual coefficient matrix ACF The results systems showed that at low ionic strength, increased linearly with...