A5061448545- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Pharmacology and Obesity Treatment
- Drug Transport and Resistance Mechanisms
- Enzyme Catalysis and Immobilization
- Advancements in Transdermal Drug Delivery
- Therapeutic Uses of Natural Elements
- Protein purification and stability
- Proteins in Food Systems
- Clay minerals and soil interactions
- Mesoporous Materials and Catalysis
- Diet and metabolism studies
- Biochemical and Molecular Research
- Surfactants and Colloidal Systems
- Polysaccharides Composition and Applications
- Signaling Pathways in Disease
- Peptidase Inhibition and Analysis
- Food Chemistry and Fat Analysis
- Biomedical Research and Pathophysiology
- Nanoparticle-Based Drug Delivery
- Body Contouring and Surgery
- Chemical Synthesis and Analysis
- Analytical Methods in Pharmaceuticals
- Antimicrobial Peptides and Activities
University of Kansas
2020-2024
University of South Australia
2015-2020
Purdue University West Lafayette
2018-2019
ARC Centre of Excellence in Advanced Molecular Imaging
2018
Ordered mesoporous silica materials have shown great potential as oral drug delivery systems for poorly soluble drugs. However, the ability of these to generate supersaturation has not been widely investigated, and recently noted phenomenon incomplete release is well understood. Therefore, aim this study was comprehensively evaluate hydrophobic molecules into solution from ordered silica, focusing on extent duration supersaturation. The dissolution behavior ritonavir, following loading...
Biocompatible lipid hybrid particles composed of montmorillonite and medium chain triglycerides were engineered for the first time by spray drying oil-in-water emulsions stabilized platelets to form montmorillonite-lipid (MLH) microparticles containing up 75% w/w lipid. In vitro lipolysis studies under simulated intestinal conditions indicated that specific porous nanoarchitecture surface chemistry MLH significantly increased rate (>10-fold) extent lipase-mediated digestion compared coarse...
Solid-state lipid-based formulations offer great potential for the improved oral delivery of poorly water-soluble drugs. This study investigates use high-surface-area clay materials, montmorillonite and laponite, as solid carriers formulations. The unique cation-exchange properties platelets were exploited to preload ionizable hydrophobic compound, blonanserin, prior encapsulating a drug-loaded lipid solution. Thus, solid-state with dual-loading capabilities developed studied. These compared...
Porous colloids have been shown to exert unique bioactivities for mediating lipid (fat) metabolism and thereby offer significant potential as anti-obesity therapies. In this study, we compare the capacity two classes of colloids, that is, smectite clays (Laponite XLG, LAP; montmorillonite, MMT) mesoporous silica (SBA-15 ordered silica; MPS), impede intestinal hydrolysis provoke carbohydrate excretion through adsorption within their particle matrices. A two-stage in vitro gastrointestinal...
The lipase‐mediated hydrolysis of triglycerides can be controlled by confining lipid droplets within highly porous nanostructured particle matrices. Novel hybrid materials with varying bioactivities toward lipase have been developed spray drying particle‐stabilized emulsions to form organized three‐dimensional architectures. In this study, the size, nanostructure, and surface chemistry particles are tailored systematically investigate influence material characteristics on activity. This is...
Lipid-based formulations can circumvent the low aqueous solubility of problematic drug compounds and increase their oral absorption. As these are often physically unstable costly to manufacture, solidification has been suggested as a way minimize issues. This study evaluated physicochemical stability in vitro performance lipid-loaded mesoporous magnesium carbonate (MMC) particles with an average pore size 20 nm. A medium chain lipid was loaded onto MMC carrier via physical adsorption....
Peptide drugs face several barriers to oral delivery, including enzymatic degradation in the gastrointestinal tract and low membrane permeability. Importantly, direct interaction between various biorelevant colloids (i.e., bile salt micelles salt-phospholipid mixed micelles) present aqueous environment peptide drug molecules has not been studied. In this work, we systematically characterized interactions a water-soluble model drug, octreotide, range of physiologically relevant salts...
Amphotericin B (AmB) is the gold standard for antifungal therapy; however, its poor solubility limits administration via intravenous infusion. A promising formulation strategy to achieve an oral development of amorphous solid dispersions (ASDs) spray-drying. Inclusion surfactants into ASDs a newer concept, yet it offers increased dissolution opportunities when combined with polymer (HPMCAS 912). We developed both binary (AmB:HPMCAS 912 or AmB:surfactant) and ternary 912:surfactant) using...