Abstract Catalytic asymmetric transformations by dearomatization have developed into a widely applicable synthetic strategy, but heavily relied on the use of arenes bearing heteroatom. In this case, is facilitated involvement p ‐orbital electron Different from conventional substrate‐dependent model, here we demonstrate that activation d transition‐metal center can serve as driving force for dearomatization, and applied to development novel alkynyl copper remote substitution reaction. A newly...

Family environments can shape children's personalities and social networks, rendering distinguishing adverse childhood experiences (ACEs) from family society essential, but related evidence remains limited.This cross-sectional study aimed to investigate the correlations between intrafamilial ACEs, their associations with depressive symptoms cognitive impairment (education-moderated) mediating role of ACEs.Data for this were China Health Retirement Longitudinal Study. Nine (0, 1, 2, 3, 4 or...

Abstract Background Internet use is a double-edged sword for older adults’ health. Whether internet can prevent cardiometabolic diseases and death in adults remains controversial. Methods Four cohorts across China, Mexico, the United States, Europe were utilized. was defined using similar questions. Cardiometabolic included diabetes, heart diseases, stroke, with 2 or more denoting multimorbidity. Depressive symptoms assessed Center Epidemiological Studies Depression Scale Europe-depression...

The cardiometabolic index (CMI) has been proposed as a novel indicator of status. This study aimed to investigate the effects CMI and its longitudinal transitions on development type 2 diabetes mellitus in middle-aged older Chinese.

Supply chain is a complex network mainly composed with raw material supplier, manufacturers, distributors, retailers and customers, being linkage of upstream downstream members. The information as an important part the supply based on effective coordination. should depend suitable coordination mechanism. This paper, through literature review introduces importance sharing in decentralized chain, particular between upstream. paper aims to report relevant research works various points view...

Fluoroalkyl(hetero)arylation of allylic alcohols with perfluoroalkyl iodide or difluoroacetic acid as fluoroalkyl source was developed herein, delivering functionalized ketones containing an α‐quaternary center. Formation the radical followed by its intermolecular addition to alkenes and migration a (hetero)aryl group concomitant generation ketone finish domino sequence. Mechanistic studies indicated that aryl proceeded through neophyl rearrangement in pathway. Moreover, preliminary...

Cardiovascular disease (CVD) has become a growing public health concern. Normal weight central obesity (NWCO) emerged as potential risk factor for cardiometabolic dysregulation. To date, the association between NWCO and new-onset CVDs remains unclear. We aimed to evaluate associations of its longitudinal transitions with cardiovascular risks in middle-aged older Chinese.Data were from China Health Retirement Longitudinal Study 2011-2018. was defined combination body mass index (BMI) <24.0...

Uncontrolled diabetes can result in severe clinical complications, significantly increasing the risk of functional limitations instrumental activities daily living (IADL) and (ADL). This study investigates association between Cascade Care (CoC) for limitations, providing evidence on critical need strengthening care to prevent improve quality life. The findings provide insights guide public health strategies interventions aimed at enhancing management across all stages CoC, with goal reducing...

Objectives: To assess the associations of triglyceride and glucose (TyG) index with hypertension stages, phenotypes, their progressions. Methods: The data originated from China Health Retirement Longitudinal Study. Multinomial logistic regression investigated TyG stages (stage 1, stage 2), phenotypes (isolated systolic [ISH], isolated diastolic [IDH], [SDH]), Results: Compared lowest quartile index, highest was associated increased risks 1 (OR 1.71, 95% CI 1.38–2.13), 2 (1.74, 1.27–2.38),...

Adverse childhood experiences (ACEs) are associated with higher depressive risks in adulthood. Whether respondents' ACEs their own symptoms adulthood and whether this association extends to spouses' remain unexplored.Data were from China Health Retirement Longitudinal Study (CHARLS), the (HRS), Survey of Health, Ageing Europe (SHARE). categorized into overall, intra-familial, extra-familial ACEs. Correlations couples' calculated using Cramer's V partial Spearman's correlation. Associations...

Prenatal malnutrition may increase the risk of depressive symptoms in adulthood. This study investigated association between prenatal exposure to with middle-aged and older adults using Chinese Great Famine 1959-1961 as a natural experiment. Data were obtained from China Health Retirement Longitudinal Study baseline survey (2011). A total 5391 individuals born 1956 1965 included study. Depressive ascertained via Center for Epidemiological Studies Depression Scale short form. severity was...

Background Depressive symptoms and cognitive impairment often interact, rendering their associations controversial. To date, joint trajectories with dementia death remain underexplored. Aims explore the interactions between depressive function, developmental all-cause dementia, Alzheimer’s disease (AD) in older adults. Methods Data were from Health Retirement Study. function measured using 8-item Centre for Epidemiologic Studies Depression Scale Telephone Interview of Cognitive Status,...

The COVID-19 vaccines have been developed in a wide range of countries. This study aimed to examine factors that related vaccination rates and willingness be vaccinated against among Chinese healthcare workers (HCWs). From 3rd February 18th February, 2021, an online cross-sectional survey was conducted HCWs investigate associated with the acceptance vaccination. Sociodemographic characteristics were evaluated. A total 2156 from 21 provinces China responded this (effective rate: 98.99%)),...

Background Diabetic retinopathy (DR) is a common complication of diabetic patients. Retinal physiological function affected by hydration status. We aimed to explore the association between status and DR. Methods National Health Nutrition Examination Survey (NHANES) 2005-2008 was used perform this cross-sectional study. Serum osmolality assess for all participants calculated evaluated only older people. DR its severity were graded into mild non-proliferative retinopathy, moderate/severe...

Adverse childhood experiences (ACEs) and dementia are associated comorbid with obesity. However, according to emerging research, the role of obesity in association between ACEs seems controversial.This analysis aimed explore associations different subtypes effect modification long-term body mass index (BMI).Data were obtained from US Health Retirement Study. Six categorised as 0, 1 2 or more. All-cause dementia, Alzheimer's disease (AD) other dementias defined by self-reported proxy-reported...

In China, numerous people still rely on solid fuel for household use. To date, the association between use and functional disability, what benefit reducing usage could bring at population level to China remain unclear.Data were from Health Retirement Longitudinal Study. Household was classified as clean or cooking heating. Functional disability defined difficulties in any item of activities daily living (ADL) instrumental (IADL). The associations 2011 its transitions 2013 with subsequent ADL...

Self-rated health (SRH), interviewer-rated (IRH), and objective reflect the overall status from different aspects. This study aimed to investigate associations of SRH, IRH, with mortality among Chinese older adults.This used data 2008 (baseline), 2011, 2014 2018 waves Longitudinal Healthy Longevity Survey. SRH IRH were evaluated by questionnaire. Objective was multimorbidity-weighted index (CMWI), which incorporated 14 diagnosed chronic diseases. CMWI assessed as: (1) baseline levels; (2)...

Certain chronic diseases contribute to increased risks of Parkinson's disease (PD), but the association between time-varying multimorbidity patterns and new-onset PD remains underexplored.Data were from Survey Health, Ageing Retirement in Europe (SHARE) waves 5-8 conducted January 2013 March 2020. Eleven included, with ≥2 denoting multimorbidity. Three further defined: somatic (SMM), neuropsychiatric (NPM), cardiometabolic (CMM). PD-related function degeneration included functional...