A5087235620- Health Systems, Economic Evaluations, Quality of Life
- Diabetes Management and Research
- Rheumatoid Arthritis Research and Therapies
- Diabetes Treatment and Management
- Spondyloarthritis Studies and Treatments
- Healthcare Policy and Management
- Global Health Care Issues
- Pharmaceutical Economics and Policy
- Gastroesophageal reflux and treatments
- Healthcare cost, quality, practices
- Chronic Disease Management Strategies
- Health Policy Implementation Science
- Biosimilars and Bioanalytical Methods
- Orthopedic Infections and Treatments
- Cardiovascular Function and Risk Factors
- Potassium and Related Disorders
- Antimicrobial Resistance in Staphylococcus
- Aquaculture disease management and microbiota
- Clinical Nutrition and Gastroenterology
- Surgical site infection prevention
- Statistical Methods in Clinical Trials
- Cardiovascular Health and Risk Factors
- Employment and Welfare Studies
- Aquaculture Nutrition and Growth
- Frailty in Older Adults
The University of Melbourne
2017-2025
Clinical Trials New Zealand
2024
Maastricht University
2011-2018
Medisch Spectrum Twente
2018
University of Twente
2018
University Medical Center
2014-2016
University Hospital and Clinics
2016
Centre Hospitalier Chrétien
2016
University Medical Center Utrecht
2015
Wageningen University & Research
2008-2011
The addition of vancomycin to beta-lactam prophylaxis in arthroplasty may reduce surgical-site infections; however, the efficacy and safety are unclear. Download a PDF Research Summary. In this multicenter, double-blind, superiority, placebo-controlled trial, we randomly assigned adult patients without known methicillin-resistant Staphylococcus aureus (MRSA) colonization who were undergoing receive 1.5 g or normal saline placebo, cefazolin prophylaxis. primary outcome was infection within 90...
The objectives of the present study were to determine, for Nile tilapia different body weights and fed satiation, (1) incipient dissolved oxygen (DO) concentration at which feed intake starts level off (2) effect DO on nitrogen energy balances. Two successive experiments conducted with two weight classes male (>200 g, Experiment 1, <100 2). Twelve aquaria assigned four levels in each experiment. Fish apparent satiation 16 20 days Experiments 1 2 respectively. DO-feed curve fish<100 g...
Abstract Background Hypochlorhydric states are an important cause of iron deficiency ( ID ). Nevertheless, the association between therapy with proton pump inhibitors PPI s) and has long been a subject debate. This case–control study aimed to investigate risk associated use s using UK Clinical Practice Research Datalink (CPRD) database. Methods Cases were patients aged 19 years or older first‐time diagnosis 2005 2016 n = 26 806). The dates first in cases defined index dates. For each case,...
It is unknown whether increasing dietary protein to 1.2-2.0 g/kg/day as recommended in international guidelines compared current practice improves outcomes intensive care unit (ICU) patients. The TARGET Protein trial will evaluate this.
BackgroundIn Australia, clinical guidelines for primary prevention of cardiovascular disease recommend the use Framingham model to help identify those at high risk developing disease. However, this has not been validated Indigenous population.
Transparency in health economic decision modelling is important for engendering confidence the models and reliability of model-based cost-effectiveness analyses. The Mount Hood Diabetes Challenge Network has taken a lead promoting transparency through validation with biennial conferences which diabetes groups meet to compare simulated outcomes pre-specified scenarios often based on results pivotal clinical trials. Model registration potential method transparency, while also reducing...
Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste.
To optimise planning of public health services, the impact high-cost users needs to be considered. However, most existing statistical models for costs do not include many clinical and social variables from administrative data that are associated with elevated care resource use, increasingly available. This study aimed use machine learning approaches big predict among people cardiovascular disease (CVD).We used nationally representative linked datasets in New Zealand CVD prevalent cases...
Abstract Background The TARGET Protein trial will evaluate the effect of greater enteral protein delivery (augmented protein) on clinical outcomes critically ill adult patients when compared to usual care. Objective To describe statistical analysis plan for trial. Methods is a cluster randomized, cross-sectional, double cross-over, open-label, registry-embedded, pragmatic conducted across Australia and New Zealand. randomized eight intensive care units (ICU) receive formula containing either...
Objective This study determined the economic impact of 16 ‘high-priority’ hospital-acquired complications (HACs), as defined by Australian Commission on Safety and Quality in Health Care, from perspective an individual health service. Methods A retrospective cohort was performed using a deidentified patient dataset containing 93 056 in-patient separations Northern (Victoria, Australia) 1 July 2016 to 30 June 2017. Two log-linked generalised linear regression models were used obtain...
Abstract Introduction The study aimed to determine the room for improvement of a perfect cerebrospinal fluid (CSF) biomarker and societal incremental net monetary benefit CSF in subjects with mild cognitive impairment (MCI) assuming hypothetical disease‐modifying Alzheimer's disease (AD) treatment. Methods A decision model compared current practice two strategies positioning as add‐on test when concluded presence or absence AD. Results simulated MCI population was aged on average 68.3 49%...
To investigate, in a cohort of patients with ankylosing spondylitis (AS) adequately treated infliximab, changes over time presenteeism and the role relative to that Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) Functional (BASFI) predicting sick leave.Data were analyzed from 71 paid work taking stable dose infliximab participating 96-week study 5 assessment points. Covariates included presenteeism, leave, time, sex, age, BASDAI, BASFI, Metrology Index, part- or full-time work....
Objective To evaluate, from a societal perspective, the incremental cost‐effectiveness of withdrawing tumor necrosis factor inhibitor ( TNF i) treatment compared to continuation these drugs within 1‐year, randomized trial among rheumatoid arthritis patients with longstanding, stable disease activity or remission. Methods Data were collected pragmatic, open‐label trial. Cost‐utility analysis was performed using nonparametric bootstrapping method, and acceptability curve constructed...
OBJECTIVE To develop a patient-level simulation model for predicting lifetime health outcomes of patients with type 1 diabetes and as tool economic evaluation treatment based on data from large, longitudinal cohort. RESEARCH DESIGN AND METHODS Data development were obtained the Swedish National Diabetes Register. We derived parametric proportional hazards models absolute risk complications death wide range clinical variables history complications. used linear regression to predict factor...
Abstract Aims/hypothesis Tables reporting life expectancies by common risk factors are available for individuals with type 2 diabetes; however, there is currently no published equivalent 1 diabetes. We aimed to develop a expectancy table using recently simulation model Methods The was developed data from real-world population of patients diabetes selected the Swedish National Diabetes Register. following six important were included in table: sex; age; current smoking status; BMI; eGFR; and...
Background Postoperative nausea and vomiting (PONV) is common after general anesthesia, with consequences for patient outcomes, satisfaction care healthcare costs. Our aim was to compare a new treatment, chewing gum, widely-used intravenous agent, ondansetron, treat PONV in female patients the post anesthesia unit (PACU). Methods We conducted multicenter, randomized, controlled non-inferiority trial 17 hospitals Australia New Zealand. Female aged ≥12 years undergoing volatile...
<h3>Objective</h3> To develop a modelling framework which can simulate long-term quality of life, societal costs and cost-effectiveness as affected by sequential drug treatment strategies for ankylosing spondylitis (AS). <h3>Methods</h3> Discrete event simulation paradigm was selected model development. Drug efficacy modelled changes in disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)) functional status Functional (BASFI)), were linked to health utility using...
Introduction Resistant Gram-positive organisms, such as methicillin-resistant staphylococci, account for a significant proportion of infections following joint replacement surgery. Current surgical antimicrobial prophylaxis guidelines recommend the use first-generation or second-generation cephalosporin antibiotics, cefazolin. Cefazolin, however, does not prevent due to these resistant organisms; therefore, new prevention strategies need be examined. One proposed strategy is combine...
Structural uncertainty can affect model-based economic simulation estimates and study conclusions. Unfortunately, unlike parameter uncertainty, relatively little is known about its magnitude of impact on life-years (LYs) quality-adjusted (QALYs) in modeling diabetes. We leveraged the Mount Hood Diabetes Challenge Network, a biennial conference attended by international diabetes groups, to assess structural simulating QALYs type 2 models.Eleven groups participated 9th Challenge. Modeling...