A5013703998- Immunotherapy and Immune Responses
- Sepsis Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Anesthesia and Pain Management
- CAR-T cell therapy research
- Infectious Diseases and Tuberculosis
- Nausea and vomiting management
- Hip and Femur Fractures
- Hemodynamic Monitoring and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genetic Syndromes and Imprinting
- Congenital limb and hand anomalies
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Machine Learning in Healthcare
- Intensive Care Unit Cognitive Disorders
- PI3K/AKT/mTOR signaling in cancer
- vaccines and immunoinformatics approaches
- Frailty in Older Adults
- Ethics in medical practice
- Morinda citrifolia extract uses
- Urinary Bladder and Prostate Research
- RNA modifications and cancer
- Dental Anxiety and Anesthesia Techniques
- Nuts composition and effects
The University of Texas MD Anderson Cancer Center
2025
University of Virginia
2019-2024
Illumina (United States)
2024
University of Virginia Health System
2015-2024
National Institutes of Health
2023
Memorial Sloan Kettering Cancer Center
2020-2022
Université Grenoble Alpes
2011-2013
Antibody-drug conjugates (ADCs) are a potent class of antineoplastic drugs that deliver cytotoxic agents via targeting with monoclonal antibodies; however, ADCs associated high rates lung toxicities, limiting the therapeutic potential in many patients. We report case patient metastatic non-small cell cancer taking ADC telisotuzumab vedotin (Teliso V) plus osimtertinib who developed ADC-induced pneumonitis despite clinical benefit. This was able to tolerate treatment for prolonged period on...
The Infinium DNA Methylation BeadChips have significantly contributed to population-scale epigenetics research by enabling epigenome-wide trait association discoveries. Here, we design, describe, and experimentally verify a new iteration of this technology, the Screening Array (MSA), focus on human screening discovery. This array utilizes extensive data from previous platform-based studies (EWAS). It incorporates knowledge latest single-cell cell type-resolution whole genome methylome...
Summary Objectives To determine if the activity‐dependent trafficking of γ2 subunit–containing γ‐aminobutyric acid type A receptors (GABA Rs) that has been observed in older animals and posited to contribute benzodiazepine pharmacoresistance during status epilepticus (SE) is age‐dependent, evaluate whether blockade protein phosphatases can inhibit or reverse plasticity these receptors. Methods The efficacy potency diazepam 0.2–10 mg/kg administered 3 60 min after onset a...
Background Immune-mediated melanoma regression relies on melanoma-reactive T cells infiltrating tumor. Cancer vaccines increase circulating cells, but little is known about vaccine-induced lymphocytes (viCLs) homing to tumor or whether interventions are needed enhance infiltration. We hypothesized that viCLs infiltrate metastases, and intratumoral interferon (IFN)-γ Toll-like receptor 7 (TLR7) agonism enhances Methods Patients two clinical trials (Mel51 ( NCT00977145 ), Mel53 NCT01264731 ))...
Catheter-associated urinary tract infections (CAUTIs) can lead to complications that prolong hospital stays and result in patient discomfort as well increased health care costs mortality. At our academic medical center New York City, 2016-17, 21 of 87 CAUTI cases (24%) were bedbound female patients whom indwelling catheters used for incontinence. Although condom available an alternative male patients, there was a lack effective products patients.A team clinical nurse specialists (CNSs)...
Abstract Blood culture acquisition is integral in the assessment of patients with sepsis, though there exists a lack clarity relating to clinical states that warrant acquisition. We investigated status critically ill children timeframe proximate blood cultures. The associated rates systemic inflammatory response syndrome (72%) and sepsis (57%) were relatively low suggesting potential overutilization Efforts are needed improve decision making at time cultures under consideration promote...
Sperm acrosomal SLLP1 binding (SAS1B) protein is found in oocytes, which necessary for sperm-oocyte interaction, and also uterine pancreatic cancers. Anti-SAS1B antibody-drug conjugates (ADCs) arrested growth these However, SAS1B expression cancers normal tissues has not been characterized. We hypothesized that expressed on the surface of other common solid cancer cells, but tissue might be selectively targeted therapeutically. human was determined by immunohistochemistry, complementary DNA...
<h3>Background</h3> T lymphocytes reactive to melanoma antigens can cause regression of advanced and mediate long-term immunologic memory. However, immune control depends on the ability cells infiltrate sites deposits. The objective this study was determine whether 6 synthetic helper peptides (6MHP) vaccine plus pembrolizumab increased infiltration vaccine-induced into tumor metastases compared 6MHP alone. <h3>Methods</h3> Patients in Mel64 (NCT02515227) received vaccines days...
Tran, Christine A. M.D.; Cramer, Christopher L. Friel, Charles M. M.D. Author Information
Fretwell, Megan; Kragie, Jennifer; Tran, Christine; Lighton, Shelby; Buck, Marcia; Frank, Deborah; Sacco, Melissa Author Information