A5102715329- Skin Protection and Aging
- Advancements in Transdermal Drug Delivery
- melanin and skin pigmentation
- Surfactants and Colloidal Systems
- Advanced Drug Delivery Systems
- Pickering emulsions and particle stabilization
- Advanced Polymer Synthesis and Characterization
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
- Lipid Membrane Structure and Behavior
- Extracellular vesicles in disease
- Telomeres, Telomerase, and Senescence
- Dyeing and Modifying Textile Fibers
- biodegradable polymer synthesis and properties
- Glycosylation and Glycoproteins Research
- Wound Healing and Treatments
- 3D Printing in Biomedical Research
- Dermatology and Skin Diseases
- Biochemical Analysis and Sensing Techniques
- Polydiacetylene-based materials and applications
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Graphene and Nanomaterials Applications
- Gold and Silver Nanoparticles Synthesis and Applications
Government of the Republic of Korea
2021
Amorepacific (South Korea)
2004-2015
Seoul National University
2007-2012
Massachusetts Institute of Technology
2007-2008
Pohang University of Science and Technology
2006
Korea National Open University
2006
We demonstrate that the surface morphology and surface-wetting behavior of layer-by-layer (LbL) films can be controlled using different deposition methods. Multilayer based upon hydrogen-bonding interactions between hydrophobically modified poly(ethylene oxide) (HM-PEO) poly(acrylic acid) (PAA) have been prepared dip- spin-assisted LbL A three-dimensional structure in dip-assisted multilayer appeared above a critical number layer pairs owing to formation micelles HM-PEO its aqueous dipping...
The aim of this study was to investigate the antioxidant properties ethanol extract flower Camellia japonica (Camellia extract). exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species (ROS) scavenging activity in human HaCaT keratinocytes. In addition, scavenged superoxide anion generated by xanthine/xanthine oxidase hydroxyl Fenton reaction (FeSO4 + H2O2) a cell-free system, which detected electron spin resonance spectrometry. Furthermore, increased...
Natural polysaccharides possess potent immunostimulatory properties, but their poor solubility impedes efficiency of cellular delivery. This study focuses on extraction microparticles (MPs) fromEuglena gracilis, a microalgae species characterized by abundant intracellular β-1,3-glucan and flexible cell membrane. We introduce anE. gracilis-derived MP (MPEG) system as natural carrier for solubilized β-glucan. The MPEG enhances β-glucan's loading through sequential sonication extrusion. In...
Hair loss is often associated with oxidative stress and mitochondrial dysfunction in human follicle dermal papilla cells (HFDPCs), resulting impaired cellular function degeneration. Thus, many studies have been conducted on natural plants aimed at inhibiting hair loss. This study investigated the therapeutic potential of exosomes derived from rhizomes Iris germanica L. (Iris-exosomes) HFDPCs damaged by dihydrotestosterone (DHT). Iris-exosomes significantly reduced reactive oxygen species...
Natural products and their derivatives historically represent alternatives to conventional synthetic molecules for pharmacotherapy, ranging from cancer chemotherapeutics cosmetic ingredients that exert anti-aging activities. Cellular senescence is considered a main driver of skin aging, yet natural target in specific manner are not thoroughly explored. Here, we performed focused compound screen identify anti-senescence effects. We found Isatis tinctoria, woad extracts, displayed senolytic...
We report the fabrication of free-standing multilayered thin films based on layer-by-layer (LbL) deposition method. The isolation multilayer film allows us to characterize materials properties such in great detail. Poly(acrylic acid) (PAA) and hydrophobically modified poly(ethylene oxide) (HM-PEO) have been prepared using LbL method upon hydrogen-bonding interactions. composition thermal were obtained as a function number layer pairs gravimetric analysis (TGA) well differential scanning...
A robust means of fabricating skin-penetrating and compatible nanocarriers comprising poly(D, L-lactide-co-glycolide) is reported. The resultant nanocapsules have the ability to load biologically active ingredients selectively release them through epidermis lipid layer. Their genistein (left figure) determined be diffusion-controlled, they are shown successfully deliver molecules, such as nile red (right figure), into biopsied skin samples. Detailed facts importance specialist readers...
Senescent fibroblasts progressively deteriorate the functional properties of skin tissue. cells secrete senescence-associated secretory phenotype (SASP) factor, which causes aging surrounding non-senescent and accelerates in individuals. Recent findings suggested senomorphic targeting SASP regulation as a new generation effective therapeutics. We investigated whether Isatis tinctoria L. leaf extract (ITE) inhibited senescence biomarkers p53, p21CDKN1A, p16INK4A gene expression, secretions by...
Abstract Mesoporous polymer microspheres with gold (Au) nanoparticles inside their pores were prepared considering surface functionality and porosity. The Au/polymer composite characterized by transmission electron microscope (TEM), X‐ray diffraction (XRD), Brunauer–Emmett–Teller (BET) techniques. results showed that the adsorption of Au could be increased imparting pore structure surface‐functional groups into supporting (in this study, poly (ethylene glycol dimethacrylate‐ co...
Abstract This study reports a facile and practical means to non‐invasively deliver biologically active ingredients through the skin using polymer‐based nanocarriers. For this, polymer nanocapsules were fabricated with different surface charges as well glass transition temperatures we observed their ability encapsulated ingredient, coenzyme Q10, layer. Direct imaging of probe molecule, Nile Red, matrix labeled fluorescence moiety, Lucifer Yellow, allowed us demonstrate that molecule readily...
Corneocytes represents the main water reservoir of stratum corneum, and that ability intimately arises from their architecture total composition. Here we describe a novel method for fabricating microgel-in-liposome (M-i-L) structure consisting sodium hyaluronate microgel lipid membrane envelop in order to mimic corneocyte cell structures. The essence our approach is use lecithin-based microemulsion with very low interfacial tension between droplet oil continuous phase. Using this emulsion...
ADVERTISEMENT RETURN TO ISSUEPREVNoteEffect of Particle Size, Composition, and Thermal Treatment on the Crystalline Structure Polycaprolactone NanoparticlesEun Chul Cho, Kilwon Jong Kun Ahn, Junoh Kim, Ih-Seop ChangView Author Information Skin Research Institute, Amorepacific Corporation/ R&D Center, 314-1, Bora-dong, Giheung-gu, Yongin, 446-729, Korea, Department Chemical Engineering, Polymer Pohang University Science Technology, Pohang, 790-784, Agricultural Science, Korea National Open...
This study has established a robust and straightforward method for the fabrication of uniform poly(vinylamine) hydrogel capsules without using templates that combines dispersion polymerization sequential hydrolysis/cross-linking. The particle sizes are determined by degree cross-linking as well reaction time, while shell thickness is independent these variables. Diffusion-limited reactions occur at periphery particles, leading to formation shells with constant thickness. treatment surfaces...